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Cav2.3 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS612325

MBS612325 is an antibody targeting Cacna1e. Also known as Cav2.3 (R-Type of Voltage-gated Calcium Channel, Cacna1e). Reactive in Rat. Host: Rabbit. More details

$670 / 0.05 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Cav2.3 (Cacna1e), Polyclonal Antibody
Full Product Name
Cav2.3 (R-Type of Voltage-gated Calcium Channel, Cacna1e)
Product Gene Name
anti-Cacna1e antibody
Product Synonym Names
Anti -Cav2.3 (R-Type of Voltage-gated Calcium Channel, Cacna1e)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Rat
Form/Format
Supplied as a lyophilized powder from PBS, pH 7.4, 1% BSA, 5% sucrose, 0.025% sodium azide. Reconstitute with 50ul deionized water.
Purity/Purification
Affinity Purified
Purified by immunoaffinity chromatography.
Specificity
Recognizes rat Cav2.3 Species sequence homology: mouse-14/16, rabbit-12/16, human-11/16
Preparation and Storage
Lyophilized powder may be stored at 4 degree C for short-term only. Reconstitute to nominal volume by adding sterile 40-50% glycerol and store at -20 degree C. Reconstituted product is stable for 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight
252,116 Da
Chromosome Location
Chromosome: 13; NC_005112.3 (76850518..77306509, complement). Location: 13q21
3D Structure
ModBase 3D Structure for Q07652
Immunogen
Epitope: peptide (C)SASQ ERSLD EGVSI DG (CNE2), corresponding to residues 892-907 of rat Cav2.3 (Accession Q07652). Epitope Location: Intracellular loop between II and III domains.

Product Categories/Family for anti-Cacna1e antibody

Antibodies; Abs to Ion Channel
Applications Tested/Suitable for anti-Cacna1e antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-Cacna1e antibody
Suitable for use in Western Blot and Immunohistochemistry.
Dilution: Western Blot: Rat brain membranes (1:200).
Immunohistochemistry: Rat brain sections.

Other Notes

Small volumes of anti-Cacna1e antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for Cacna1e. It may not necessarily be applicable to this product.

NCBI GI #
14578563
NCBI GeneID
54234
NCBI Accession #
AAK33009.1
UniProt Primary Accession #
Q07652
UniProt Related Accession #
Q07652
NCBI Official Full Name
calcium channel isoform alpha1E7
NCBI Official Synonym Full Names
calcium channel, voltage-dependent, R type, alpha 1E subunit
NCBI Official Symbol
Cacna1e
NCBI Official Synonym Symbols
CACHA1E
UniProt Protein Name
Voltage-dependent R-type calcium channel subunit alpha-1E
UniProt Synonym Protein Names
BII; Brain calcium channel II; Calcium channel, L type, alpha-1 polypeptide, isoform 6; RBE-II; RBE2; Voltage-gated calcium channel subunit alpha Cav2.3
Protein Family
Voltage-dependent R-type calcium channel
UniProt Gene Name
Cacna1e
UniProt Synonym Gene Names
Cach6; Cacnl1a6
UniProt Entry Name
CAC1E_RAT
NCBI Protein Information
voltage-dependent R-type calcium channel subunit alpha-1E; BII; RBE2; RBE-II; brain calcium channel II; voltage gated calcium channel alpha1E subunit; voltage-dependent calcium channel alpha1-E subunit; voltage-gated calcium channel subunit alpha Cav2.3; calcium channel, L type, alpha-1 polypeptide, isoform 6; calcium channel, voltage-dependent, L type, alpha 1E subunit

NCBI Summary for Cacna1e

T-type low voltage-activated calcium channel that may be involved in neuronal firing [RGD, Feb 2006]

UniProt Comments for Cacna1e

CACNA1E: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1E gives rise to R-type calcium currents. R-type calcium channels belong to the 'high-voltage activated' (HVA) group and are blocked by nickel, and partially by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to dihydropyridines (DHP), omega- conotoxin-GVIA (omega-CTx-GVIA), and omega-agatoxin-IVA (omega- Aga-IVA). Calcium channels containing alpha-1E subunit could be involved in the modulation of firing patterns of neurons which is important for information processing. Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1E subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; Channel, calcium

Cellular Component: voltage-gated calcium channel complex; perikaryon

Molecular Function: voltage-gated calcium channel activity; low voltage-gated calcium channel activity; high voltage-gated calcium channel activity; protein N-terminus binding; calcium ion binding

Biological Process: fear response; behavioral fear response; regulation of heart rate; response to pain; transmission of nerve impulse; locomotory behavior; sensory perception of pain; glucose homeostasis; neurological system process; synaptic transmission; sperm motility; behavioral response to pain; calcium ion transport; visual learning
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Research Articles on Cacna1e

1. quartet of leucine residues in the guanylate kinase domain of CaVbeta determines the plasma membrane density of the CaV2.3 channel.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-Cacna1e antibody

 Products by Pathway  Pathway Diagram
 Calcium Regulation In The Cardiac Cell Pathway antibodies  Calcium Regulation In The Cardiac Cell Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Depolarization Of The Presynaptic Terminal Triggers The Opening Of Calcium Channels Pathway antibodies  Depolarization Of The Presynaptic Terminal Triggers The Opening Of Calcium Channels Pathway Diagram
 Integration Of Energy Metabolism Pathway antibodies  Integration Of Energy Metabolism Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Neuronal System Pathway antibodies  Neuronal System Pathway Diagram
 Regulation Of Insulin Secretion Pathway antibodies  Regulation Of Insulin Secretion Pathway Diagram

Organs/Tissues associated with anti-Cacna1e antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >39 publications with Cacna1e and Brain
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