Sheep Anti-MAPK4 Polyclonal Antibody – Cat# MBS612553

MAP Kinase P63 (MAPK4) Antibody – Sheep Polyclonal

Name: MAPK4 Antibody; Polyclonal; Sheep; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS612553
Price: 935 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS612553

The heterogeneous expression of human MAP (Mitogen Activated Protein) kinase isoforms in differentiated tissues may reflect the diversity of the signal transduction pathways in differentiated cells. MAP kinases also known as erks have been established to… More details

$935 / 0.25 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

MAP Kinase p63 (MAPK4), Polyclonal Antibody

Full Product Name

MAP Kinase p63 (MAP Kinase Isoform p63, p63-MAPK, p63MAPK, Extracellular Signal-regulated Kinase 4, ERK4, ERK-4, Mitogen-activated Protein Kinase 4, MAP Kinase 4, MAPK 4, MAPK4, PRKM4)

Product Gene Name

anti-MAPK4 antibody

Product Synonym Names

Anti -MAP Kinase p63 (MAP Kinase Isoform p63, p63-MAPK, p63MAPK, Extracellular Signal-regulated Kinase 4, ERK4, ERK-4, Mitogen-activated Protein Kinase 4, MAP Kinase 4, MAPK 4, MAPK4, PRKM4)

Clonality

Polyclonal

Isotype

IgG

Host

Sheep

Species Reactivity

Human

Form/Format

Supplied as a liquid in PBS, pH 7.5. No preservative added.

Purity/Purification

Affinity Purified
Purified by Protein G affinity chromatography.

Specificity

Recognizes p63 MAP Kinase: 100%.

Preparation and Storage

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Molecular Weight

65,922 Da

Chromosome Location

Chromosome: 18; NC_000018.9 (48086484..48258196). Location: 18q21.1

OMIM

176949

3D Structure

ModBase 3D Structure for P31152

Immunogen

C-terminal region of human p63 MAP kinase (cDNA/GST expressed in E. coli).

Product Categories/Family for anti-MAPK4 antibody

Antibodies; Abs to Protein Kinases

Applications Tested/Suitable for anti-MAPK4 antibody

Western Blot (WB), Immunoprecipitation (IP), Immunohistochemistry (IHC)

Application Notes for anti-MAPK4 antibody

Suitable for use in Western Blot, Immunoprecipitation, Immunohistochemistry.
Dilution: Western Blot: 5-10ug/ml
Immunoprecipitation: 5ug/sample
Immunohistochemistry: 1:10-1:50

Other Notes

Small volumes of anti-MAPK4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MAPK4 purchase

MBS612553 is an antibody targeting MAPK4. Also known as MAP Kinase p63 (MAP Kinase Isoform p63, p63-MAPK, p63MAPK, Extracellular Signal-regulated Kinase 4, ERK4, ERK-4, Mitogen-activated Protein Kinase 4, MAP Kinase 4, MAPK 4, MAPK4, PRKM4). Reactive in Human. Host: Sheep.

Additional Details

NCBI/Uniprot data below describe general gene information for MAPK4. It may not necessarily be applicable to this product.

NCBI GI #

89276769

NCBI GeneID

5596

NCBI Accession #

NP_002738.2

UniProt Primary Accession #

P31152

UniProt Related Accession #

P31152

GenBank Nucleotide #

NM_002747.3

NCBI Official Full Name

mitogen-activated protein kinase 4

NCBI Official Synonym Full Names

mitogen-activated protein kinase 4

NCBI Official Symbol

MAPK4

NCBI Official Synonym Symbols

ERK3; Erk4; ERK-4; PRKM4; MAPK 4; p63MAPK

UniProt Protein Name

Mitogen-activated protein kinase 4

UniProt Synonym Protein Names

Extracellular signal-regulated kinase 4; ERK-4; MAP kinase isoform p63

UniProt Gene Name

MAPK4

UniProt Synonym Gene Names

ERK4; PRKM4; MAP kinase 4; MAPK 4; ERK-4; p63-MAPK

UniProt Entry Name

MK04_HUMAN

NCBI Protein Information

mitogen-activated protein kinase 4; p63-MAPK; Erk3-related; MAP kinase 4; MAP kinase isoform p63; extracellular signal-regulated kinase 4

NCBI Summary for MAPK4

Mitogen-activated protein kinase 4 is a member of the mitogen-activated protein kinase family. Tyrosine kinase growth factor receptors activate mitogen-activated protein kinases which then translocate into the nucleus where it phosphorylates nuclear targets. [provided by RefSeq, Jul 2008]

UniProt Comments for MAPK4

ERK4: a protein kinase of the MAPK family. Phosphorylation and activations leads to translocation into the nucleus where it phosphorylates nuclear targets.

Protein type: Protein kinase, CMGC; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.24; CMGC group; MAPK family; MAPK/ERK subfamily; ERK subfamily

Chromosomal Location of Human Ortholog: 18q21.1

Cellular Component: cytoplasm; nucleus

Molecular Function: MAP kinase activity; protein binding; protein homodimerization activity; protein heterodimerization activity; protein kinase binding; ATP binding

Biological Process: MAPKKK cascade; cell cycle; protein amino acid phosphorylation

Research Articles on MAPK4

1. A previously unknown role for ERK3 in promoting lung cancer cell invasiveness by phosphorylating SRC-3 and regulating SRC-3 proinvasive activity by site-specific phosphorylation.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-MAPK4 antibody

Reference Product	PubMed Publications
MAPKAPK5 antibody	>4 publications with MAPK4 and MAPKAPK5

Pathways associated with anti-MAPK4 antibody

Products by Pathway	Pathway Diagram
B Cell Receptor Signaling Pathway antibodies	B Cell Receptor Signaling Pathway Diagram
Focal Adhesion Pathway antibodies	Focal Adhesion Pathway Diagram
Insulin Signaling Pathway antibodies	Insulin Signaling Pathway Diagram
Integrated Pancreatic Cancer Pathway antibodies	Integrated Pancreatic Cancer Pathway Diagram
Integrin-mediated Cell Adhesion Pathway antibodies	Integrin-mediated Cell Adhesion Pathway Diagram
MAPK Signaling Pathway antibodies	MAPK Signaling Pathway Diagram
MicroRNAs In Cardiomyocyte Hypertrophy Pathway antibodies	MicroRNAs In Cardiomyocyte Hypertrophy Pathway Diagram
Regulation Of Actin Cytoskeleton Pathway antibodies	Regulation Of Actin Cytoskeleton Pathway Diagram
Signal Transduction Of S1P Receptor Pathway antibodies	Signal Transduction Of S1P Receptor Pathway Diagram

Diseases associated with anti-MAPK4 antibody

Disease Name	Pubmed Publications
Neoplasms Antibodies	>5 publications with MAPK4 and Neoplasms
Disease Models, Animal Antibodies	>2 publications with MAPK4 and Disease Models, Animal
Inflammation Antibodies	>1 publications with MAPK4 and Inflammation

Organs/Tissues associated with anti-MAPK4 antibody

Organ/Tissue Name	Pubmed Publications
Nerve Antibodies	>3 publications with MAPK4 and Nerve
Lung Antibodies	>2 publications with MAPK4 and Lung
Embryonic Tissue Antibodies	>1 publications with MAPK4 and Embryonic Tissue
Eye Antibodies	>1 publications with MAPK4 and Eye
Brain Antibodies	>1 publications with MAPK4 and Brain