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GATA2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS613896

The zinc finger transcription factor GATA-2 is widely expressed and plays an essential role in many developmental processes (1). Studies on GATA-2 knockout mice indicate that this protein is required in hematopoiesis (2). GATA-2 also inhibits the… More details

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Product Overview

Online Datasheet in PDF
Product Name
GATA2, Polyclonal Antibody
Full Product Name
GATA2 (GATA Binding Factor 2, GATA Binding Protein 2)
Product Gene Name
anti-GATA2 antibody
Product Synonym Names
Anti -GATA2 (GATA Binding Factor 2, GATA Binding Protein 2)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
Supplied as a liquid in 10mM sodium HEPES, pH 7.5, 150mM sodium chloride, 0.1mg/ml BSA, 50% glycerol.
Purity/Purification
Affinity Purified
Purified by Protein A and peptide affinity chromatography.
Specificity
Detects endogenous levels of total human GATA-2 protein at ~51kD. Species Crossreactivity: mouse and rat
Preparation and Storage
May be stored at 4 degree C for short-term only. For long-term storage, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight
50,500 Da
Chromosome Location
Chromosome: 3; NC_000003.11 (128198265..128212030, complement). Location: 3q21.3
OMIM
137295
3D Structure
ModBase 3D Structure for Q96BH8
Immunogen
Synthetic peptide (KLH-coupled) derived from the sequence of human GATA-2.

Product Categories/Family for anti-GATA2 antibody

Antibodies; Abs to Transcription Factors; Zinc (Ring) Finger
Applications Tested/Suitable for anti-GATA2 antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-GATA2 antibody
Suitable for use in ELISA and Western Blot.
Dilution: Western Blot: 1:1000

Western Blot (WB) of anti-GATA2 antibody

Western Blot analysis of extracts from HeLa and 293 cells using MBS613896.
Rabbit Anti-GATA2 Polyclonal Antibody – Cat# MBS613896

Other Notes

Small volumes of anti-GATA2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GATA2 purchase

MBS613896 is an antibody targeting GATA2. Also known as GATA2 (GATA Binding Factor 2, GATA Binding Protein 2). Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for GATA2. It may not necessarily be applicable to this product.

NCBI GI #
30410878
NCBI GeneID
2624
UniProt Primary Accession #
Q96BH8
UniProt Secondary Accession #
Q53YE0; Q96BH0; Q96BH8; Q9BUJ6; D3DNB3
UniProt Related Accession #
P23769
NCBI Official Full Name
GATA2 protein
NCBI Official Synonym Full Names
GATA binding protein 2
NCBI Official Symbol
GATA2
NCBI Official Synonym Symbols
NFE1B; MGC2306; FLJ45948
UniProt Protein Name
Endothelial transcription factor GATA-2
UniProt Synonym Protein Names
GATA-binding protein 2
Protein Family
Endothelial transcription factor
UniProt Gene Name
GATA2
UniProt Entry Name
GATA2_HUMAN
NCBI Protein Information
endothelial transcription factor GATA-2; OTTHUMP00000216238; OTTHUMP00000216239; OTTHUMP00000216240

NCBI Summary for GATA2

This gene encodes a member of the GATA family of zinc-finger transcription factors that are named for the consensus nucleotide sequence they bind in the promoter regions of target genes. The encoded protein plays an essential role in regulating transcription of genes involved in the development and proliferation of hematopoietic and endocrine cell lineages. Alternative splicing results in multiple transcript variants.
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UniProt Comments for GATA2

GATA2: Transcriptional activator which regulates endothelin-1 gene expression in endothelial cells. Binds to the consensus sequence 5'-AGATAG-3'. Endothelial cells. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Transcription factor

Chromosomal Location of Human Ortholog: 3q21.3

Cellular Component: nucleoplasm; protein complex

Molecular Function: protein binding; zinc ion binding; chromatin binding; transcription factor binding; transcription factor activity

Biological Process: inner ear morphogenesis; embryonic placenta development; transcription, DNA-dependent; somatic stem cell maintenance; positive regulation of erythrocyte differentiation; cell maturation; regulation of histone acetylation; cell fate determination; negative regulation of transcription from RNA polymerase II promoter; negative regulation of fat cell differentiation; phagocytosis; cell differentiation in hindbrain; positive regulation of angiogenesis; negative regulation of macrophage differentiation; homeostasis of number of cells within a tissue; ventral spinal cord interneuron differentiation; commitment of a neuronal cell to a specific type of neuron in the forebrain; pituitary gland development; positive regulation of phagocytosis; negative regulation of Notch signaling pathway; positive regulation of megakaryocyte differentiation; positive regulation of transcription from RNA polymerase II promoter; blood coagulation; urogenital system development; central nervous system neuron development

Disease: Lymphedema, Primary, With Myelodysplasia; Immunodeficiency 21; Myelodysplastic Syndrome
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Research Articles on GATA2

1. The genome-wide binding sites for the GATA2 in primary human megakaryocytes to identify the essential regulator of complex mammalian differentiation processes.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-GATA2 antibody

 Reference Product  PubMed Publications
 CEBPA antibody  >16 publications with GATA2 and CEBPA
 ZFPM1 antibody  >13 publications with GATA2 and ZFPM1
 JUN antibody  >8 publications with GATA2 and JUN

Pathways associated with anti-GATA2 antibody

 Products by Pathway  Pathway Diagram
 Adipogenesis Pathway antibodies  Adipogenesis Pathway Diagram
 Factors Involved In Megakaryocyte Development And Platelet Production Pathway antibodies  Factors Involved In Megakaryocyte Development And Platelet Production Pathway Diagram
 HIF-1-alpha Transcription Factor Network Pathway antibodies  HIF-1-alpha Transcription Factor Network Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 IL-3 Signaling Pathway antibodies  IL-3 Signaling Pathway Diagram
 Regulation Of Androgen Receptor Activity Pathway antibodies  Regulation Of Androgen Receptor Activity Pathway Diagram
 SIDS Susceptibility Pathways antibodies  SIDS Susceptibility Pathways Diagram
 Signaling Events Mediated By HDAC Class I Pathway antibodies  Signaling Events Mediated By HDAC Class I Pathway Diagram
 Signaling Events Mediated By HDAC Class II Pathway antibodies  Signaling Events Mediated By HDAC Class II Pathway Diagram

Diseases associated with anti-GATA2 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >95 publications with GATA2 and Neoplasms
 Leukemia Antibodies  >87 publications with GATA2 and Leukemia
 Leukemia, Myeloid Antibodies  >54 publications with GATA2 and Leukemia, Myeloid
 Leukemia, Myeloid, Acute Antibodies  >38 publications with GATA2 and Leukemia, Myeloid, Acute
 Anemia Antibodies  >25 publications with GATA2 and Anemia
 Carcinoma Antibodies  >12 publications with GATA2 and Carcinoma
 Congenital Abnormalities Antibodies  >12 publications with GATA2 and Congenital Abnormalities
 Inflammation Antibodies  >12 publications with GATA2 and Inflammation
 Cardiovascular Diseases Antibodies  >11 publications with GATA2 and Cardiovascular Diseases
 Drug Toxicity Antibodies  >8 publications with GATA2 and Drug Toxicity

Organs/Tissues associated with anti-GATA2 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >212 publications with GATA2 and Blood
 Embryonic Tissue Antibodies  >76 publications with GATA2 and Embryonic Tissue
 Bone Marrow Antibodies  >64 publications with GATA2 and Bone Marrow
 Vascular Antibodies  >60 publications with GATA2 and Vascular
 Brain Antibodies  >43 publications with GATA2 and Brain
 Muscle Antibodies  >20 publications with GATA2 and Muscle
 Heart Antibodies  >20 publications with GATA2 and Heart
 Kidney Antibodies  >18 publications with GATA2 and Kidney
 Placenta Antibodies  >15 publications with GATA2 and Placenta
 Spleen Antibodies  >13 publications with GATA2 and Spleen
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