Mouse Anti-BRMS1 Monoclonal Antibody – Cat# MBS6146159

BRMS1 Antibody – Mouse Monoclonal

Name: BRMS1 Antibody; Monoclonal; Mouse; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS6146159
Price: 1140 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6146159

This gene reduces the metastatic potential, but not the tumorogenicity, of human breast cancer and melanoma cell lines. The protein encoded by this gene localizes primarily to the nucleus and is a component of the mSin3a family of histone deacetylase… More details

$1140 / 0.1 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

BRMS1, Monoclonal Antibody

Full Product Name

BRMS1 (Breast Cancer Metastasis-suppressor 1) (FITC)

Product Gene Name

anti-BRMS1 antibody

Clonality

Monoclonal

Isotype

IgG1,k

Clone Number

2D4-2G11

Host

Mouse

Species Reactivity

Human

Form/Format

Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Fluorescein isothiocyanate (FITC).

Purity/Purification

Purified by Protein A Affinity Chromatography.

Specificity

Recognizes human BRMS1.

Preparation and Storage

Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: FITC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Immunogen

Full length recombinant corresponding to aa1-246, from human BRMS1 (AAH09834) with GST tag. MW of the GST tag alone is 26kD.

Immunogen Sequence

MPVQPPSKDTEEMEAEGDSAAEMNGEEEESEEERSGSQTESEEESSEMDDEDYERRRSECVSEMLDLEKQFSELKEKLFRERLSQLRLRLEEVGAERAPEYTEPLGGLQRSLKIRIQVAGIYKGFCLDVIRNKYECELQGAKQHLESEKLLLYDTLQGELQERIQRLEEDRQSLDLSSEWWDDKLHARGSSRSWDSLPPSKRKKAPLVSGPYIVYMLQEIDILEDWTAIKKARAAVSPQKRKSDGP

Conjugate

FITC

Product Categories/Family for anti-BRMS1 antibody

Antibodies; Cancer Markers

Applications Tested/Suitable for anti-BRMS1 antibody

ELISA (EIA), Immunoprecipitation (IP), Western Blot (WB)

Application Notes for anti-BRMS1 antibody

Applications are based on unconjugated antibody.

Product References and Citations for anti-BRMS1 antibody

1. Low BRMS1 expression promotes nasopharyngeal carcinoma metastasis in vitro and in vivo and is associated with poor patient survival. Cui RX, Liu N, He QM, Li WF, Huang BJ, Sun Y, Tang LL, Chen M, Jiang N, Chen L, Yun JP, Zeng J, Guo Y, Wang HY, Ma J.BMC Cancer. 2012 Aug 29;12(1):376. 2. Breast Cancer Metastasis Suppressor 1 (BRMS1) is destabilized by the Cul3-SPOP E3 ubiquitin ligase complex. Kim B, Nam HJ, Pyo KE, Jang MJ, Kim IS, Kim D, Boo K, Lee SH, Yoon JB, Baek SH, Kim JH.Biochem Biophys Res Commun. 2011 Nov 9. 3. BRMS1 transcriptional repression correlates with CpG island methylation and advanced pathologic stage in non-small cell lung cancer. Nagji AS, Liu Y, Stelow EB, Stukenborg GJ, Jones DR.The Journal of Pathology (2010), DOI: 10.1002/path.2707. 4. Breast cancer metastasis suppressor 1 (BRMS1) suppresses metastasis and correlates with improved patient survival in non-small cell lung cancer. Smith PW, Liu Y, Siefert SA, Moskaluk CA, Petroni GR, Jones DR.Cancer Lett. 2009 Apr 18;276(2):196-203. Epub 2008 Dec 25. 5. Proteomics-Based Strategy To Delineate the Molecular Mechanisms of the Metastasis Suppressor Gene BRMS1. Rivera J, Megias D, Bravo J.J Proteome Res. 2007 Oct;6(10):4006-18. Epub 2007 Sep 14. 6. Breast cancer metastasis suppressor 1 functions as a corepressor by enhancing HDAC1-mediated deacetylation of RelA/p65 and promoting apoptosis. Liu Y, Smith PW, Jones DR.Mol Cell Biol. 2006 Dec;26(23):8683-96. Epub 2006 Sep 25.

Other Notes

Small volumes of anti-BRMS1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for BRMS1 purchase

MBS6146159 is an antibody targeting BRMS1. Also known as BRMS1 (Breast Cancer Metastasis-suppressor 1) (FITC). Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for BRMS1. It may not necessarily be applicable to this product.

NCBI GI #

14602633

NCBI GeneID

25855

NCBI Accession #

AAH09834

UniProt Related Accession #

Q9HCU9

NCBI Official Full Name

Breast cancer metastasis suppressor 1

NCBI Official Synonym Full Names

BRMS1 transcriptional repressor and anoikis regulator

NCBI Official Symbol

BRMS1

Protein Family

Breast cancer metastasis-suppressor

NCBI Protein Information

breast cancer metastasis-suppressor 1

Research Articles on BRMS1

1. suggest that BRMS! NLS2 is a disordered region, with non pre-formed structure, that participates in metastasis suppression

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.