Estrogen Receptor B1, B2 Antibody – Rabbit Polyclonal

Mouse/rat ERb1 gene encodes a protein of 485aa with a calculated size of approx. 54kD (1). Compared to ERa, ERb1 is highly conserved in the DNA-binding domain (> 90% homology) and the C-terminal ligand binding domain (55% homology). The A/B domain, the hinge region and the F-domain are not conserved. Rat ERb1 is primarily expressed in prostate, ovary, lung, bladder, brain, uterus and testis. Most recently functional variants of ERb1, termed ERb2, have been cloned. ERb2 has an additional 18aa as a results of in-frame mutation within the ligand-binding domain. ERb2 is expressed in ovary, prostate, pituitary, brain and muscle. Variants of both ERb1 and ERb2 (ERb1d3, ERb2d3) were detected that show deletion of 39aa in the DNA-binding domain. Both ERb1 and ERb2 specifically bind to ER response element. ERa, b1 and ERb2 have been found to heterodimerize with each other.

Small volumes of anti-Estrogen Receptor b1, b2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS615151 is an antibody targeting Estrogen Receptor b1, b2. Also known as Estrogen Receptor b1, b2 (ERb1, 2). Reactive in Human. Host: Rabbit.