Adenosine A1 Receptor (ADORA1) Antibody – Rabbit Polyclonal

The purine nucleoside adenosine modulates diverse physiological functions including induction of sedation, vasodilatation, suppression of cardiac rate and contractility, neurotransmitter release, inhibition of platelet aggregation and lipolysis. Adenosine released from cells interacts with membrane receptors (adenosine receptors, ARs). Based upon, biochemical and pharmacological criteria, ARs have been classified into A1, A2a, A2b and A3. The high affinity receptor A1 inhibits adenyl cyclase. Low affinity receptor A2a stimulates the cyclase via G proteins. A2a receptor is believed to cause vasorelaxation in coronary artery. Various, ARs and their subtypes have recently been cloned from several species. ARs belong to the superfamily of G-protein coupled receptors. They are predicted to contain 7 transmembrane domains. The N-termini are predicted to be extracellular. The C-termini is predicted to be cytoplasmic. There is an overall 30% homology among the four ARs. ARs are distributed throughout the body. Gene location of various ARs: A1 (Chromosome 1; q.31.3-32.2); A2a (Chromosome 22); A2b (Chromosome 17; p.11.2-12); A3 (Chromos.1).

• 1. Mahan, L.C., et al., Mol. Pharmacol. 40: 1-7 (1991). 2. Reppert, S.M., et al., Mol. Endocrinol. 5: 1037-38 (1991). 3. Tucker, A.L., Linden, J., Cardiovascular Res. 27: 62-67 (1993). 4. Olah, M.E., Stile, G., Ann. Rev. Pharmacol. 35: 581-606 (1995). 5. Ciruela, F., J. Neurosci. 42: 818-828 (1995).

Small volumes of anti-ADORA1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS615163 is an antibody targeting ADORA1. Also known as Anti - Adenosine A1 Receptor (A1R). Reactive in Rat. Host: Rabbit
Source: Rat.