FXYD Domain-Containing Ion Transport Regulator 1 (FXYD1) Antibody – Mouse Monoclonal

This gene encodes a member of the FXYD family of small membrane proteins that share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD and containing 7 invariant and 6 highly conserved amino acids. The protein encoded by this gene is a plasma membrane substrate for several kinases, including protein kinase A, protein kinase C, NIMA kinase, and myotonic dystrophy kinase. It is thought to form an ion channel or regulate ion channel activity and act as an accessory protein of Na,K-ATPase. Alternatively spliced transcript variants have been described. [provided by RefSeq, Sep 2009]

PLM: a protein of the FXYD family of small ion transport regulators or channels. Induces a hyperpolarization-activated chloride current when expressed in Xenopus oocytes. May have a functional role in muscle contraction. Major plasma membrane substrate for PKA and PKC in several different tissues. Phosphorylated in response to insulin and adrenergic stimulation.Highest expression in skeletal muscle and heart. Moderate levels in brain, placenta, lung, liver, pancreas, uterus, bladder, prostate, small intestine and colon with mucosal lining.

Protein type: Cell surface; Channel, misc.; Membrane protein, integral

Cellular Component: membrane; integral to plasma membrane; cell; plasma membrane; integral to membrane; caveola; sarcolemma

Molecular Function: chloride channel activity; sodium channel regulator activity; myosin binding; ion channel activity; ATPase binding

Biological Process: positive regulation of organic acid transport; cytosolic calcium ion homeostasis; transport; chloride transport; ion transport