Goat Anti-HMGCR Polyclonal Antibody – Cat# MBS619782

HMG-Coa Reductase (HMGCR) Antibody – Goat Polyclonal

Name: HMGCR Antibody; Polyclonal; Goat; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS619782
Price: 835 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS619782

HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in… More details

$835 / 0.1 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

HMG-CoA Reductase (Hmgcr), Polyclonal Antibody

Full Product Name

HMG-CoA Reductase (3-hydroxy-3-methylglutaryl-Coenzyme A reductase, LDLCQ3, HMGCR)

Product Gene Name

anti-Hmgcr antibody

Product Synonym Names

Anti -HMG-CoA Reductase (3-hydroxy-3-methylglutaryl-Coenzyme A reductase, LDLCQ3, HMGCR)

Clonality

Polyclonal

Isotype

IgG

Host

Goat

Species Reactivity

Human

Form/Format

Supplied as a liquid in Tris, pH 7.3, 0.5% BSA, 0.02% sodium azide.

Purity/Purification

Affinity Purified
Purified by immunoaffinity chromatography.

Specificity

Recognizes human HMG-CoA Reductase.

Preparation and Storage

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Molecular Weight

98,317 Da

Chromosome Location

Chromosome: 3R; NT_033777.2 (19559046..19576868). Location: 95B1-95B1; 3-80.0 cM

3D Structure

ModBase 3D Structure for P14773

Immunogen

Synthetic peptide corresponding to C-ADPSPQNSTADTSK, from the internal region of human HMG-CoA Reductase (NP_000850).

Positive Control

Human Brain (Cerebellum), Liver, Skeletal Muscle and Adipose lysates

Product Categories/Family for anti-Hmgcr antibody

Antibodies; Abs to CoEnzyme A

Applications Tested/Suitable for anti-Hmgcr antibody

ELISA (EL/EIA)

Application Notes for anti-Hmgcr antibody

Suitable for use in ELISA.
Dilution: ELISA:1:8000

Other Notes

Small volumes of anti-Hmgcr antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Hmgcr purchase

MBS619782 is an antibody targeting Hmgcr. Also known as HMG-CoA Reductase (3-hydroxy-3-methylglutaryl-Coenzyme A reductase, LDLCQ3, HMGCR). Reactive in Human. Host: Goat.

Additional Details

NCBI/Uniprot data below describe general gene information for Hmgcr. It may not necessarily be applicable to this product.

NCBI GI #

281362379

NCBI GeneID

42803

NCBI Accession #

NP_001163703.1

UniProt Primary Accession #

P14773

UniProt Secondary Accession #

Q9VCI8; A4V3A8

UniProt Related Accession #

P14773

GenBank Nucleotide #

NM_001170232.1

NCBI Official Full Name

HMG coenzyme A reductase, isoform C

NCBI Official Synonym Full Names

HMG Coenzyme A reductase

NCBI Official Symbol

Hmgcr

NCBI Official Synonym Symbols

BcDNA:LD15354; bro1; bs32f05.y1; CG10367; clb; Clb; DmelCG10367; DmHMG-CoAr; Hmg; HmG-CoAR; hmgc; HMGCoAr; HMGCoAR; HMGCoARr; hmgcr; HMGCR; HMGCR_Dm; hmgrc; l(3)01152

UniProt Protein Name

3-hydroxy-3-methylglutaryl-coenzyme A reductase

Protein Family

HMG-CoA reductase inhibitor

UniProt Gene Name

Hmgcr

UniProt Synonym Gene Names

HmG-CoAR

UniProt Entry Name

HMDH_DROME

NCBI Protein Information

CG10367 gene product from transcript CG10367-RA; HMG coenzyme A reductase, isoform A; CG10367-PA; Hmgcr-PA; columbus; HMGCo-A reductase; 3-hydroxy-3-methylglutaryl coenzyme A reductase; Hmg-CoA-reductase; HMG-CoA reductase; HMGCoA reductase; 3-Hydroxy-3-Methylglutaryl CoA reductase; HMG coenzyme A reductase, isoform B; CG10367-PB; Hmgcr-PB; HMG coenzyme A reductase, isoform C; CG10367-PC; Hmgcr-PC

UniProt Comments for Hmgcr

Function: Synthesis of mevalonate for the production of non-sterol isoprenoids, which are essential for growth differentiation. Provides spatial information during embryogenesis to guide migrating primordial germ cells (the pole cells) from the ectoderm to the mesoderm. Also required for association of the pole cells with the gonadal mesoderm. Ref.4

Catalytic activity: (R)-mevalonate + CoA + 2 NADP+ = (S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH.

Enzyme regulation: The activity of HMG-CoA-reductase is suppressed by exogenous mevalonate. Ref.1

Pathway: Metabolic intermediate biosynthesis; (R)-mevalonate biosynthesis; (R)-mevalonate from acetyl-CoA: step 3/3.

Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein.

Tissue specificity: Highly expressed in embryonic gonadal mesoderm, where expression is initially broad, and then becomes restricted to a segmental pattern at stage 11. Expression is then further restricted to a cluster of cells in each of parasegments 10, 11 and 12, corresponding to the developing gonadal mesoderm. Not expressed in pole cells. Ref.4

Sequence similarities: Belongs to the HMG-CoA reductase family.Contains 1 SSD (sterol-sensing) domain.

Research Articles on Hmgcr

1. The specificity and evolutionary conservation of the HMGCoAr pathway for germ cells suggest that an attractant common to invertebrates and vertebrates guides germ cells in early embryos.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-Hmgcr antibody

Products by Pathway	Pathway Diagram
Cholesterol Biosynthesis Pathway antibodies	Cholesterol Biosynthesis Pathway Diagram
Metabolic Pathways antibodies	Metabolic Pathways Diagram
Metabolism Of Lipids And Lipoproteins Pathway antibodies	Metabolism Of Lipids And Lipoproteins Pathway Diagram
Terpenoid Backbone Biosynthesis Pathway antibodies	Terpenoid Backbone Biosynthesis Pathway Diagram
Terpenoid Backbone Biosynthesis Pathway antibodies	Terpenoid Backbone Biosynthesis Pathway Diagram

Diseases associated with anti-Hmgcr antibody

Disease Name	Pubmed Publications
Metabolic Diseases Antibodies	>37 publications with Hmgcr and Metabolic Diseases
Neoplasms Antibodies	>33 publications with Hmgcr and Neoplasms
Cardiovascular Diseases Antibodies	>31 publications with Hmgcr and Cardiovascular Diseases
Vascular Diseases Antibodies	>27 publications with Hmgcr and Vascular Diseases
Hypercholesterolemia Antibodies	>23 publications with Hmgcr and Hypercholesterolemia
Dyslipidemias Antibodies	>23 publications with Hmgcr and Dyslipidemias
Fatty Liver Antibodies	>22 publications with Hmgcr and Fatty Liver
Hyperlipidemias Antibodies	>21 publications with Hmgcr and Hyperlipidemias
Atherosclerosis Antibodies	>21 publications with Hmgcr and Atherosclerosis
Myocardial Ischemia Antibodies	>18 publications with Hmgcr and Myocardial Ischemia

Organs/Tissues associated with anti-Hmgcr antibody

Organ/Tissue Name	Pubmed Publications
Testis Antibodies	>2 publications with Hmgcr and Testis
Whole Body Antibodies	>1 publications with Hmgcr and Whole Body