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LYVE-1 (LYVE1) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS620246

The lymphatic vasculature forms a second circulatory system that drains extracellular fluid from the tissues and provides an exclusive environment in which immune cells can encounter and respond to foreign antigen. Recently a number of interesting molecules… More details

$895 / 0.1 mL +1 FREE 8GB USB
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Testing Data View PDF
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Product Overview

Online Datasheet in PDF
Product Name
LYVE-1 (LYVE1), Polyclonal Antibody
Full Product Name
LYVE-1 (Lymphatic Vessel Endothelial Hyaluronic Acid Receptor, LYVE1, CRSBP1, Extracellular Link Domain Containing 1, Hyaluronic Acid Receptor, HAR, Lymphatic Endothelium Specific Hyaluronan Receptor, Lymphatic Vessel Endothelial Hyaluronan Receptor 1, XL
Product Gene Name
anti-LYVE1 antibody
Product Synonym Names
Anti -LYVE-1 (Lymphatic Vessel Endothelial Hyaluronic Acid Receptor, LYVE1, CRSBP1, Extracellular Link Domain Containing 1, Hyaluronic Acid Receptor, HAR, Lymphatic Endothelium Specific Hyaluronan Receptor, Lymphatic Vessel Endothelial Hyaluronan Receptor 1, XL
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
Supplied as liquid in Tris-glycine, pH 7.5, 150mM sodium chloride, 0.05% sodium azide.
Purity/Purification
Affinity Purified
Purified by affinity chromatography.
Specificity
Recognizes mouse LYVE-1at ~45kD.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
35,213 Da
Chromosome Location
Chromosome: 11; NC_000011.9 (10578712..10590365, complement). Location: 11p15
OMIM
605702
3D Structure
ModBase 3D Structure for Q9Y5Y7
Immunogen
Synthetic peptide corresponding to aa250-318 from the C-terminal region of murine LYVE-1.

Product Categories/Family for anti-LYVE1 antibody

Antibodies; Abs to Receptors
Applications Tested/Suitable for anti-LYVE1 antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-LYVE1 antibody
Suitable for Western Blot and Immunohistochemistry. Not suitable for human in Western Blot.
Dilution: Western Blot: 8ug/ml. Tested with mouse spleen lysates. Not suitable for human in Western Blot
Immunohistochemistry: 1:100. Citrate buffer antigen retrieval is recommended.

Testing Data of anti-LYVE1 antibody

LYVE-1 staining of endothelial cells of human lung blood vessels using MBS620246.. Note presence of RBCs within vessel lumen.
Rabbit Anti-LYVE1 Polyclonal Antibody – Cat# MBS620246

Testing Data of anti-LYVE1 antibody

Detection of LYVE-1 in mouse spleen lysates. ECL detection overnight using MBS620246.
Rabbit Anti-LYVE1 Polyclonal Antibody, Testing Data – Cat# MBS620246

Other Notes

Small volumes of anti-LYVE1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for LYVE1 purchase

MBS620246 is an antibody targeting LYVE1. Also known as LYVE-1 (Lymphatic Vessel Endothelial Hyaluronic Acid Receptor, LYVE1, CRSBP1, Extracellular Link Domain Containing 1, Hyaluronic Acid Receptor, HAR, Lymphatic Endothelium Specific Hyaluronan Receptor, Lymphatic Vessel Endothelial Hyaluronan Receptor 1, XL. Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for LYVE1. It may not necessarily be applicable to this product.

NCBI GI #
40549451
NCBI GeneID
10894
NCBI Accession #
NP_006682.2
UniProt Primary Accession #
Q9Y5Y7
UniProt Secondary Accession #
Q8TC18; Q9UNF4
UniProt Related Accession #
Q9Y5Y7
GenBank Nucleotide #
NM_006691.3
NCBI Official Full Name
lymphatic vessel endothelial hyaluronic acid receptor 1
NCBI Official Synonym Full Names
lymphatic vessel endothelial hyaluronan receptor 1
NCBI Official Symbol
LYVE1
NCBI Official Synonym Symbols
HAR; XLKD1; LYVE-1; CRSBP-1
UniProt Protein Name
Lymphatic vessel endothelial hyaluronic acid receptor 1
UniProt Synonym Protein Names
Cell surface retention sequence-binding protein 1; CRSBP-1; Extracellular link domain-containing protein 1; Hyaluronic acid receptor
Protein Family
Lymphatic vessel endothelial hyaluronic acid receptor
UniProt Gene Name
LYVE1
UniProt Synonym Gene Names
CRSBP1; HAR; XLKD1; LYVE-1; CRSBP-1
UniProt Entry Name
LYVE1_HUMAN
NCBI Protein Information
lymphatic vessel endothelial hyaluronic acid receptor 1; extracellular link domain containing 1; extracellular link domain-containing 1; extracellular link domain-containing protein 1; cell surface retention sequence binding protein-1; cell surface retention sequence-binding protein 1

NCBI Summary for LYVE1

This gene encodes a type I integral membrane glycoprotein. The encoded protein acts as a receptor and binds to both soluble and immobilized hyaluronan. This protein may function in lymphatic hyaluronan transport and have a role in tumor metastasis. [provided by RefSeq, Jul 2008]

UniProt Comments for LYVE1

XLKD1: Ligand-specific transporter trafficking between intracellular organelles (TGN) and the plasma membrane. Plays a role in autocrine regulation of cell growth mediated by growth regulators containing cell surface retention sequence binding (CRS). May act as an hyaluronan (HA) transporter, either mediating its uptake for catabolism within lymphatic endothelial cells themselves, or its transport into the lumen of afferent lymphatic vessels for subsequent re-uptake and degradation in lymph nodes.

Protein type: Membrane protein, integral; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 11p15

Cellular Component: membrane; integral to plasma membrane; plasma membrane

Molecular Function: transmembrane receptor activity; hyaluronic acid binding; receptor activity

Biological Process: anatomical structure morphogenesis; glycosaminoglycan metabolic process; transport; cell-matrix adhesion; carbohydrate metabolic process; response to wounding; pathogenesis; signal transduction; cell motility; hyaluronan metabolic process; hyaluronan catabolic process
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Research Articles on LYVE1

1. FGF2 binds to LYVE-1 with a higher affinity than any other known LYVE-1-binding molecules, such as hyaluronan or PDGF-BB. Glycosylation of LYVE-1 is important for FGF2 binding.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-LYVE1 antibody

 Reference Product  PubMed Publications
 VEGFC antibody  >56 publications with LYVE1 and VEGFC
 CD44 antibody  >16 publications with LYVE1 and CD44
 IGFBP3 antibody  >2 publications with LYVE1 and IGFBP3
 ATM antibody  >1 publications with LYVE1 and ATM
 STAB2 antibody  >1 publications with LYVE1 and STAB2

Pathways associated with anti-LYVE1 antibody

 Products by Pathway  Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Glycosaminoglycan Metabolism Pathway antibodies  Glycosaminoglycan Metabolism Pathway Diagram
 Hyaluronan Metabolism Pathway antibodies  Hyaluronan Metabolism Pathway Diagram
 Hyaluronan Uptake And Degradation Pathway antibodies  Hyaluronan Uptake And Degradation Pathway Diagram
 MPS I - Hurler Syndrome Pathway antibodies  MPS I - Hurler Syndrome Pathway Diagram
 MPS II - Hunter Syndrome Pathway antibodies  MPS II - Hunter Syndrome Pathway Diagram
 MPS IIIA - Sanfilippo Syndrome A Pathway antibodies  MPS IIIA - Sanfilippo Syndrome A Pathway Diagram
 MPS IIIB - Sanfilippo Syndrome B Pathway antibodies  MPS IIIB - Sanfilippo Syndrome B Pathway Diagram
 MPS IIIC - Sanfilippo Syndrome C Pathway antibodies  MPS IIIC - Sanfilippo Syndrome C Pathway Diagram
 MPS IIID - Sanfilippo Syndrome D Pathway antibodies  MPS IIID - Sanfilippo Syndrome D Pathway Diagram

Diseases associated with anti-LYVE1 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >126 publications with LYVE1 and Neoplasms
 Carcinoma Antibodies  >49 publications with LYVE1 and Carcinoma
 Breast Neoplasms Antibodies  >19 publications with LYVE1 and Breast Neoplasms
 Adenocarcinoma Antibodies  >17 publications with LYVE1 and Adenocarcinoma
 Neoplasms, Experimental Antibodies  >13 publications with LYVE1 and Neoplasms, Experimental
 Lung Neoplasms Antibodies  >13 publications with LYVE1 and Lung Neoplasms
 Disease Models, Animal Antibodies  >10 publications with LYVE1 and Disease Models, Animal
 Liver Neoplasms Antibodies  >9 publications with LYVE1 and Liver Neoplasms
 Necrosis Antibodies  >8 publications with LYVE1 and Necrosis
 Liver Diseases Antibodies  >8 publications with LYVE1 and Liver Diseases

Organs/Tissues associated with anti-LYVE1 antibody

 Organ/Tissue Name  Pubmed Publications
 Vascular Antibodies  >160 publications with LYVE1 and Vascular
 Lung Antibodies  >20 publications with LYVE1 and Lung
 Eye Antibodies  >18 publications with LYVE1 and Eye
 Liver Antibodies  >14 publications with LYVE1 and Liver
 Embryonic Tissue Antibodies  >13 publications with LYVE1 and Embryonic Tissue
 Muscle Antibodies  >11 publications with LYVE1 and Muscle
 Stomach Antibodies  >9 publications with LYVE1 and Stomach
 Connective Tissue Antibodies  >8 publications with LYVE1 and Connective Tissue
 Bone Antibodies  >8 publications with LYVE1 and Bone
 Heart Antibodies  >7 publications with LYVE1 and Heart
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