Adrenergic Receptor, Beta 3 (ADRB3) Antibody – Rabbit Polyclonal

The protein encoded by this gene belongs to the family of beta adrenergic receptors, which mediate catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor is located mainly in the adipose tissue and is involved in the regulation of lipolysis and thermogenesis. [provided by RefSeq]

ADRB3: Beta-adrenergic receptors mediate the catecholamine- induced activation of adenylate cyclase through the action of G proteins. Beta-3 is involved in the regulation of lipolysis and thermogenesis. Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB3 sub-subfamily.

Protein type: Membrane protein, integral; Receptor, GPCR; GPCR, family 1; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 8p12

Cellular Component: integral to plasma membrane; plasma membrane; nucleus; receptor complex

Molecular Function: beta3-adrenergic receptor activity; protein binding; protein homodimerization activity; beta-3 adrenergic receptor binding; norepinephrine binding; epinephrine binding; beta-adrenergic receptor activity

Biological Process: arrestin mediated desensitization of G-protein coupled receptor protein signaling pathway; receptor-mediated endocytosis; generation of precursor metabolites and energy; diet induced thermogenesis; negative regulation of multicellular organism growth; eating behavior; adenylate cyclase activation; G-protein signaling, adenylate cyclase activating pathway; G-protein signaling, coupled to cAMP nucleotide second messenger; response to antibiotic; G-protein signaling, coupled to cyclic nucleotide second messenger; positive regulation of MAPKKK cascade; heat generation; carbohydrate metabolic process; brown fat cell differentiation; energy reserve metabolic process; response to cold; aging; norepinephrine-epinephrine vasodilation involved in regulation of systemic arterial blood pressure

Disease: Obesity