Fragile X Mental Retardation, Autosomal Homolog 1, L662 Antibody – Rabbit Polyclonal

Fragile X syndrome is a genetic disorder characterized by a spectrum of physical and behavioral features and is a frequent form of inherited mental retardation (1). The X-linked FMRP (FMR-1) and its two autosomal homologs, FXR1 and FXR2, are polyribosome-associated RNA-binding proteins that are involved in the pathogenesis of fragile X syndrome (1-3). Each of the fragile X proteins can self-associate as well as form heteromers with the other two related proteins (3). FMRP can act as a translation regulator and is a component of RNAi effector complexes (RISC), suggesting a role in gene silencing (4). The Drosophila homolog of FMRP (dFMRP) associates with Argonaute2 (Ago2) and Dicer and can coimmunoprecipitate with miRNA and siRNA (5). These results suggest that fragile X syndrome is related to abnormal translation caused by defects in RNAi-related pathways.

Small volumes of anti-Fragile X Mental Retardation, Autosomal Homolog 1, L662 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS620693 is an antibody targeting Fragile X Mental Retardation, Autosomal Homolog 1, L662. Also known as Fragile X Mental Retardation, Autosomal Homolog 1, L662 (FXR1, Fragile X Mental Retardation Syndrome-related Protein 1, Fragile X Mental Retardation-related Protein 1, hFXR1p). Reactive in Mouse. Host: Rabbit.