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anti-AKR1A1 antibody :: Rabbit anti-Human, Mouse AKR1A1 Polyclonal Antibody

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Catalog # MBS7047648
Unit / Price
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  0.05 mg  /  $160 +1 FREE 8GB USB
  0.1 mg  /  $235 +1 FREE 8GB USB
Product Name

AKR1A1, Polyclonal Antibody

Popular Item
Full Product Name

AKR1A1 Antibody

Product Synonym Names
Alcohol dehydrogenase [NADP(+)]; Aldehyde reductase; Aldo-keto reductase family 1 member A1; AKR1A1; ALDR1; ALR
Research Use Only
For Research Use Only. Not for use in diagnostic procedures.
OMIM
J04794 mRNA
3D Structure
ModBase 3D Structure for P14550
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Purity/Purification
>95%, Protein G purified
Form/Format
Liquid
Immunogen
Recombinant Human Alcohol dehydrogenase [NADP(+)] protein (2-325AA)
Preservative
0.03% Proclin 300
Constituents
50% Glycerol, 0.01M PBS, PH 7.4
Conjugation
Non-conjugated
Santa Cruz Alternative
Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-161328 / sc-161329
Preparation and Storage
Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
ISO Certification
Manufactured in an ISO 9001:2008 Certified Laboratory.
Other Notes
Small volumes of anti-AKR1A1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Related Product Information for
anti-AKR1A1 antibody
Catalyzes the NADPH-dependent reduction of a variety of aromatic and aliphatic aldehydes to their corresponding alcohols. Catalyzes the reduction of mevaldate to mevalonic acid and of glyceraldehyde to glycerol. Has broad substrate specificity. In vitro substrates include succinic semialdehyde, 4-nitrobenzaldehyde, 1, 2-naphthoquinone, methylglyoxal, and D-glucuronic acid. Plays a role in the activation of procarcinogens, such as polycyclic aromatic hydrocarbon trans-dihydrodiols, and in the metabolism of various xenobiotics and drugs, including the anthracyclines doxorubicin (DOX) and daunorubicin (DAUN).
Applications Tested/Suitable for anti-AKR1A1 antibody
ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
Application Notes for anti-AKR1A1 antibody
WB: 1: 2000-1: 10000
IHC: 1: 20-1: 200
IF: 1: 50-1: 200

Western Blot (WB) of anti-AKR1A1 antibody
Western Blot
Positive WB detected in:Mouse liver tissue,Mouse kidney tissue,Mouse stomach tissue
All lanes: Akr1a1 antibody at 2.8ug/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 37 kDa
Observed band size: 37,23 kDa

anti-AKR1A1 antibody Western Blot (WB) (WB) image
Immunohistochemistry (IHC) of anti-AKR1A1 antibody
Immunohistochemistry of paraffin-embedded human kidney tissue using MBS7047648 at dilution of 1:100
anti-AKR1A1 antibody Immunohistochemistry (IHC) (IHC) image
Immunohistochemistry (IHC) of anti-AKR1A1 antibody
Immunofluorescent analysis of Hela cells using MBS7047648 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
anti-AKR1A1 antibody Immunohistochemistry (IHC) (IHC) image
NCBI/Uniprot data below describe general gene information for AKR1A1. It may not necessarily be applicable to this product.
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
36,573 Da
NCBI Official Full Name
alcohol dehydrogenase
NCBI Official Synonym Full Names
aldo-keto reductase family 1 member A1
NCBI Official Symbol
AKR1A1  [Similar Products]
NCBI Official Synonym Symbols
ALR; ARM; DD3; ALDR1; HEL-S-6
  [Similar Products]
NCBI Protein Information
alcohol dehydrogenase [NADP(+)]
UniProt Protein Name
Alcohol dehydrogenase [NADP(+)]
UniProt Synonym Protein Names
Aldehyde reductase; Aldo-keto reductase family 1 member A1
Protein Family
UniProt Gene Name
AKR1A1  [Similar Products]
UniProt Synonym Gene Names
ALDR1; ALR  [Similar Products]
UniProt Entry Name
AK1A1_HUMAN
NCBI Summary for AKR1A1
This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member, also known as aldehyde reductase, is involved in the reduction of biogenic and xenobiotic aldehydes and is present in virtually every tissue. Multiple alternatively spliced transcript variants of this gene exist, all encoding the same protein. [provided by RefSeq, Jan 2011]
UniProt Comments for AKR1A1
AKR1A1: Catalyzes the NADPH-dependent reduction of a variety of aromatic and aliphatic aldehydes to their corresponding alcohols. Catalyzes the reduction of mevaldate to mevalonic acid and of glyceraldehyde to glycerol. Has broad substrate specificity. In vitro substrates include succinic semialdehyde, 4- nitrobenzaldehyde, 1,2-naphthoquinone, methylglyoxal, and D- glucuronic acid. Plays a role in the activation of procarcinogens, such as polycyclic aromatic hydrocarbon trans-dihydrodiols, and in the metabolism of various xenobiotics and drugs, including the anthracyclines doxorubicin (DOX) and daunorubicin (DAUN). Belongs to the aldo/keto reductase family.

Protein type: Carbohydrate Metabolism - glycolysis and gluconeogenesis; EC 1.1.1.2; Lipid Metabolism - glycerolipid; Oxidoreductase

Chromosomal Location of Human Ortholog: 1p33-p32

Cellular Component: cytosol; extracellular space

Molecular Function: aldo-keto reductase activity; electron carrier activity; L-glucuronate reductase activity; protein binding

Biological Process: aldehyde metabolic process; glucose metabolic process; glucuronate catabolic process to xylulose 5-phosphate
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Products associated withanti-AKR1A1 antibody
 Reference Product  PubMed Publications
 ALDH1A3 antibody  >1 publications with AKR1A1 and ALDH1A3
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