Rabbit Anti-SHANK1 Polyclonal Antibody – Cat# MBS620894

SHANK1 Antibody – Rabbit Polyclonal

Name: SHANK1 Antibody; Polyclonal; Rabbit; Human/Rat-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS620894
Price: 875 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS620894

Shank is a novel family of postsynaptic density proteins (PSD) that bind to PSD-95-associated protein GKAP. Its putative function is to act as a scaffold protein in the PSD to cross-link NMDA receptors/PSD-95 complexes and couple them to regulators of the… More details

$875 / 0.1 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

SHANK1, Polyclonal Antibody

Full Product Name

SHANK1 (SH3 and Multiple Ankyrin Repeat Domains 1, SH3 and Multiple Ankyrin Repeat Domains Protein 1, GKAP/SAPAP-interacting Protein, Somatostatin Receptor Interacting Protein, SPANK1, SPANK-1, SSTR-interacting Protein, SSTRIP, Synamon)

Product Gene Name

anti-SHANK1 antibody

Product Synonym Names

Anti -SHANK1 (SH3 and Multiple Ankyrin Repeat Domains 1, SH3 and Multiple Ankyrin Repeat Domains Protein 1, GKAP/SAPAP-interacting Protein, Somatostatin Receptor Interacting Protein, SPANK1, SPANK-1, SSTR-interacting Protein, SSTRIP, Synamon)

Clonality

Polyclonal

Host

Rabbit

Species Reactivity

Human, Rat

Form/Format

Supplied as a liquid in PBS, pH 7.2.

Purity/Purification

Affinity Purified
Purified by immunoaffinity chromatography.

Specificity

Reacts with residues [ERLLREYPQSFEKGV] of the N terminus of the rat Shank1a protein. Species Crossreactivity: Reacts with human and rat Shank1a. Does not react with mouse Shank1a.

Preparation and Storage

May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Molecular Weight

224,959 Da

Chromosome Location

Chromosome: 19; NC_000019.9 (51165084..51220195, complement). Location: 19q13.3

OMIM

604999

3D Structure

ModBase 3D Structure for Q9Y566

Cellular Localization

Cytoplasmic; postsynaptic density of neuronal cells.

Product Categories/Family for anti-SHANK1 antibody

Antibodies; Abs to Neuroscience

Applications Tested/Suitable for anti-SHANK1 antibody

Western Blot (WB)

Application Notes for anti-SHANK1 antibody

Suitable for use in Western Blot.

Other Notes

Small volumes of anti-SHANK1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SHANK1 purchase

MBS620894 is an antibody targeting SHANK1. Also known as SHANK1 (SH3 and Multiple Ankyrin Repeat Domains 1, SH3 and Multiple Ankyrin Repeat Domains Protein 1, GKAP/SAPAP-interacting Protein, Somatostatin Receptor Interacting Protein, SPANK1, SPANK-1, SSTR-interacting Protein, SSTRIP, Synamon). Reactive in Human, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for SHANK1. It may not necessarily be applicable to this product.

NCBI GI #

120587025

NCBI GeneID

50944

NCBI Accession #

NP_057232.2

UniProt Primary Accession #

Q9Y566

UniProt Secondary Accession #

Q9NYW9; A8MXP5; B7WNY6

UniProt Related Accession #

Q9Y566

GenBank Nucleotide #

NM_016148.2

NCBI Official Full Name

SH3 and multiple ankyrin repeat domains protein 1

NCBI Official Synonym Full Names

SH3 and multiple ankyrin repeat domains 1

NCBI Official Symbol

SHANK1

NCBI Official Synonym Symbols

SSTRIP; SPANK-1; synamon

UniProt Protein Name

SH3 and multiple ankyrin repeat domains protein 1

UniProt Synonym Protein Names

Somatostatin receptor-interacting protein

Protein Family

SH3 and multiple ankyrin repeat domains protein

UniProt Gene Name

SHANK1

UniProt Entry Name

SHAN1_HUMAN

NCBI Protein Information

SH3 and multiple ankyrin repeat domains protein 1; OTTHUMP00000174437; OTTHUMP00000174438; SSTR-interacting protein; somatostatin receptor-interacting protein

UniProt Comments for SHANK1

SHANK1: Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and Homer, respectively, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction. Belongs to the SHANK family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 19q13.3

Cellular Component: postsynaptic membrane; neuron projection; membrane; cytoplasm; dendrite; plasma membrane; dendritic spine; excitatory synapse; ionotropic glutamate receptor complex; intracellular; cell junction; N-methyl-D-aspartate selective glutamate receptor complex

Molecular Function: protein C-terminus binding; somatostatin receptor binding; ionotropic glutamate receptor binding; identical protein binding; protein binding; protein complex binding; GKAP/Homer scaffold activity; SH3 domain binding

Biological Process: determination of affect; negative regulation of actin filament bundle formation; habituation; synapse maturation; olfactory behavior; long-term memory; cytoskeletal anchoring; righting reflex; adult behavior; protein complex assembly; social behavior; neuromuscular process controlling balance; associative learning

Research Articles on SHANK1

1. Results show that dendritic targeting of shank1 mRNA granules involves KIF5C and the KIF5-associated RNA-binding protein staufen1.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-SHANK1 antibody

Reference Product	PubMed Publications
SHARPIN antibody	>2 publications with SHANK1 and SHARPIN
BAIAP2 antibody	>2 publications with SHANK1 and BAIAP2
HOMER1 antibody	>1 publications with SHANK1 and HOMER1
DLG4 antibody	>1 publications with SHANK1 and DLG4

Pathways associated with anti-SHANK1 antibody

Products by Pathway	Pathway Diagram
Glutamatergic Synapse Pathway antibodies	Glutamatergic Synapse Pathway Diagram
Glutamatergic Synapse Pathway antibodies	Glutamatergic Synapse Pathway Diagram

Diseases associated with anti-SHANK1 antibody

Disease Name	Pubmed Publications
Autistic Disorder Antibodies	>2 publications with SHANK1 and Autistic Disorder
Anxiety Disorders Antibodies	>1 publications with SHANK1 and Anxiety Disorders

Organs/Tissues associated with anti-SHANK1 antibody

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>37 publications with SHANK1 and Brain
Intestine Antibodies	>1 publications with SHANK1 and Intestine