Goat Anti-PLXNC1 Polyclonal Antibody – Cat# MBS623073

Plexin C1 (PLXNC1) Antibody – Goat Polyclonal

Name: PLXNC1 Antibody; Polyclonal; Goat; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS623073
Price: 860 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS623073

Plexin C1, also known as Virus-encoded semaphorin protein receptor (VESPR) and CD232, is a 210kD type I transmembrane glycoprotein in the C subfamily of the large plexin family. It is widely expressed in neuronal and non-neuronal fetal and adult tissues.… More details

$860 / 0.1 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Plexin C1 (PLXNC1), Polyclonal Antibody

Full Product Name

Plexin C1 (CD232, Virus-Encoded Semaphorin Protein Receptor, VESPR)

Product Gene Name

anti-PLXNC1 antibody

Product Synonym Names

Anti -Plexin C1 (CD232, Virus-Encoded Semaphorin Protein Receptor, VESPR)

Clonality

Polyclonal

Isotype

IgG

Host

Goat

Species Reactivity

Human

Form/Format

Supplied as a lyophilized powder from PBS, 5% trehalose. Reconstitute with 500ul sterile PBS.

Purity/Purification

Affinity Purified
Purified by Immunoaffinity chromatography.

Specificity

Recognizes human Plexin C1. In direct ELISAs and Western Blots, this antibody shows ~10% crossreactivity with recombinant mouse Plexin A1, A2, and A3, recombinant human Plexin B1, and <1% crossreactivity with recombinant human Plexin D1.

Preparation and Storage

Lyophilized powder may be stored at -20 degree C. Stable for 12 months at -20 degree C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Reconstituted product is stable for 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Molecular Weight

175,742 Da

Chromosome Location

Chromosome: 12; NC_000012.11 (94542499..94699225). Location: 12q23.3

OMIM

604259

3D Structure

ModBase 3D Structure for O60486

Immunogen

E. coli-derived recombinant human Plexin C1 (aa49-161), Accession #: O60486. Species Sequence Homology: mouse (92%).

Product Categories/Family for anti-PLXNC1 antibody

Antibodies; Abs to Plexin; Semaphorin

Applications Tested/Suitable for anti-PLXNC1 antibody

ELISA (EL/EIA), Western Blot (WB), Flow Cytometry (FC/FACS)

Application Notes for anti-PLXNC1 antibody

Suitable for use in Western Blot, Flow Cytometry and Direct ELISA.
Dilution: Western Blot: 0.1-0.2ug/ml; The detection limit is ~1ng/lane under non-reducing and reducing conditions.
Flow Cytometry: 50ug/ml; Add 10ul of the diluted solution to 1-2.5x10e5 cells in a total reaction volume not exceeding 200ul. The binding of unlabeled antibodies may be visualized by adding 10ul of a 25ug/ml stock solution of a secondary developing reagent such as anti-goat lgG conjugated to a fluorochrome. Tested on white blood monocytes.
Direct ELISA: 0.5-1.0ug/ml; The detection limit is ~0.5ng/well.

Other Notes

Small volumes of anti-PLXNC1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PLXNC1 purchase

MBS623073 is an antibody targeting PLXNC1. Also known as Plexin C1 (CD232, Virus-Encoded Semaphorin Protein Receptor, VESPR). Reactive in Human. Host: Goat.

Additional Details

NCBI/Uniprot data below describe general gene information for PLXNC1. It may not necessarily be applicable to this product.

NCBI GI #

5032223

NCBI GeneID

10154

NCBI Accession #

NP_005752.1

UniProt Primary Accession #

O60486

UniProt Secondary Accession #

Q59H25

UniProt Related Accession #

O60486

GenBank Nucleotide #

NM_005761.2

NCBI Official Full Name

plexin-C1

NCBI Official Synonym Full Names

plexin C1

NCBI Official Symbol

PLXNC1

NCBI Official Synonym Symbols

CD232; VESPR; PLXN-C1

UniProt Protein Name

Plexin-C1

UniProt Synonym Protein Names

Virus-encoded semaphorin protein receptor

Protein Family

Plexin

UniProt Gene Name

PLXNC1

UniProt Synonym Gene Names

VESPR

UniProt Entry Name

PLXC1_HUMAN

NCBI Protein Information

plexin-C1; plexin (semaphorin receptor); receptor for viral semaphorin protein; receptor for virally-encoded semaphorin; virus-encoded semaphorin protein receptor

NCBI Summary for PLXNC1

This gene encodes a member of the plexin family. Plexins are transmembrane receptors for semaphorins, a large family of proteins that regulate axon guidance, cell motility and migration, and the immune response. The encoded protein and its ligand regulate melanocyte adhesion, and viral semaphorins may modulate the immune response by binding to this receptor. The encoded protein may be a tumor suppressor protein for melanoma. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq]

UniProt Comments for PLXNC1

PLXNC1: Receptor for SEMA7A, for smallpox semaphorin A39R, vaccinia virus semaphorin A39R and for herpesvirus Sema protein. Binding of semaphorins triggers cellular responses leading to the rearrangement of the cytoskeleton and to secretion of IL6 and IL8. Belongs to the plexin family.

Protein type: Membrane protein, integral; Motility/polarity/chemotaxis; Cell adhesion

Chromosomal Location of Human Ortholog: 12q23.3

Cellular Component: membrane; integral to membrane; plasma membrane; intracellular

Molecular Function: protein binding; receptor activity; receptor binding

Biological Process: axon guidance; cell adhesion; signal transduction

Research Articles on PLXNC1

1. Study reports the structures of Sema7A and A39R complexed with the Semaphorin-binding module of PlexinC1; both structures show two PlexinC1 molecules symmetrically bridged by Semaphorin dimers.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-PLXNC1 antibody

Products by Pathway	Pathway Diagram
Axon Guidance Pathway antibodies	Axon Guidance Pathway Diagram
Axon Guidance Pathway antibodies	Axon Guidance Pathway Diagram
Axon Guidance Pathway antibodies	Axon Guidance Pathway Diagram
Other Semaphorin Interactions Pathway antibodies	Other Semaphorin Interactions Pathway Diagram
Semaphorin Interactions Pathway antibodies	Semaphorin Interactions Pathway Diagram

Diseases associated with anti-PLXNC1 antibody

Disease Name	Pubmed Publications
Neoplasms Antibodies	>2 publications with PLXNC1 and Neoplasms
Leukemia, Myeloid, Acute Antibodies	>1 publications with PLXNC1 and Leukemia, Myeloid, Acute
Pancreatic Neoplasms Antibodies	>1 publications with PLXNC1 and Pancreatic Neoplasms
Leukemia Antibodies	>1 publications with PLXNC1 and Leukemia
Leukemia, Myeloid Antibodies	>1 publications with PLXNC1 and Leukemia, Myeloid
Adenocarcinoma Antibodies	>1 publications with PLXNC1 and Adenocarcinoma

Organs/Tissues associated with anti-PLXNC1 antibody

Organ/Tissue Name	Pubmed Publications
Embryonic Tissue Antibodies	>1 publications with PLXNC1 and Embryonic Tissue
Mouth Antibodies	>1 publications with PLXNC1 and Mouth
Lung Antibodies	>1 publications with PLXNC1 and Lung
Testis Antibodies	>1 publications with PLXNC1 and Testis
Kidney Antibodies	>1 publications with PLXNC1 and Kidney
Brain Antibodies	>1 publications with PLXNC1 and Brain