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DTYMK Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS623882

Thymidylate kinase (DTYMK) catalyzes the phosphorylation of dTMP to form dTDP in the dTTP synthesis pathway for DNA synthesis. DTYMK is essential for DNA synthesis and is an important intermediate enzyme in the pathway of many pyrimidine analog drugs,… More details

$895 / 0.2 mL +1 FREE 8GB USB
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
DTYMK, Polyclonal Antibody
Full Product Name
DTYMK, CT (Thymidylate Kinase, dTMP Kinase, CDC8, TMPK, TYMK)
Product Gene Name
anti-DTYMK antibody
Product Synonym Names
Anti -DTYMK, CT (Thymidylate Kinase, dTMP Kinase, CDC8, TMPK, TYMK)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
Supplied as a liquid in PBS, 0.09% sodium azide.
Purity/Purification
Affinity Purified
Purified by Protein G affinity chromatography.
Specificity
Recognizes human DTYMK. Species Crossreactivity: mouse.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
23,819 Da
Chromosome Location
Chromosome: 2; NC_000002.11 (242615157..242626383, complement). Location: 2q37.3
3D Structure
ModBase 3D Structure for Q6FGU2
Immunogen
Synthetic peptide selected from the C-terminal region of human DTYMK (KLH).

Product Categories/Family for anti-DTYMK antibody

Antibodies; Abs to Enzymes
Applications Tested/Suitable for anti-DTYMK antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-DTYMK antibody
Suitable for use in ELISA and Western Blot.
Dilution: ELISA: 1:1,000
Western Blot: 1:100-1:500

Western Blot (WB) of anti-DTYMK antibody

The anti-DTYMK Pab is used in Western blot to detect DTYMK in mouse colon tissue lysate.
Rabbit Anti-DTYMK Polyclonal Antibody – Cat# MBS623882

Other Notes

Small volumes of anti-DTYMK antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for DTYMK purchase

MBS623882 is an antibody targeting DTYMK. Also known as DTYMK, CT (Thymidylate Kinase, dTMP Kinase, CDC8, TMPK, TYMK). Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for DTYMK. It may not necessarily be applicable to this product.

NCBI GI #
49456983
NCBI GeneID
1841
UniProt Primary Accession #
Q6FGU2
UniProt Related Accession #
P23919; Q53F55; Q6FGU2; Q8WY85
NCBI Official Full Name
DTYMK
NCBI Official Synonym Full Names
deoxythymidylate kinase (thymidylate kinase)
NCBI Official Symbol
DTYMK
NCBI Official Synonym Symbols
CDC8; TMPK; TYMK; PP3731; FLJ44192; MGC198617
UniProt Protein Name
DTYMK protein
UniProt Gene Name
DTYMK
UniProt Synonym Gene Names
tmp_locus_5
UniProt Entry Name
Q6FGU2_HUMAN
NCBI Protein Information
thymidylate kinase; dTMP kinase; OTTHUMP00000164604; OTTHUMP00000200145; OTTHUMP00000200146

UniProt Comments for DTYMK

DTYMK: Catalyzes the conversion of dTMP to dTDP. Belongs to the thymidylate kinase family.

Protein type: Mitochondrial; EC 2.7.4.9; Kinase, other; Nucleotide Metabolism - pyrimidine

Chromosomal Location of Human Ortholog: 2q37.3

Cellular Component: mitochondrion; mitochondrial matrix; mitochondrial intermembrane space; cytosol; nucleus

Molecular Function: uridylate kinase activity; thymidylate kinase activity; nucleoside phosphate kinase activity; ATP binding

Biological Process: myoblast differentiation; cell proliferation; response to cadmium ion; nucleoside monophosphate phosphorylation; nucleobase, nucleoside and nucleotide metabolic process; response to estrogen stimulus; nucleobase, nucleoside and nucleotide interconversion; dUDP biosynthetic process; dTDP biosynthetic process; dTTP biosynthetic process; cell cycle; nucleotide phosphorylation
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Research Articles on DTYMK

1. Lentiviral delivery of small hairpin RNA targeting TMPK in combination with a low dose of doxorubicin as a new approach to kill colon cancer cells regardless of p53 status.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-DTYMK antibody

 Products by Pathway  Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Of Nucleotides Pathway antibodies  Metabolism Of Nucleotides Pathway Diagram
 Pyrimidine Metabolism Pathway antibodies  Pyrimidine Metabolism Pathway Diagram
 Pyrimidine Metabolism Pathway antibodies  Pyrimidine Metabolism Pathway Diagram
 Synthesis And Interconversion Of Nucleotide Di- And Triphosphates Pathway antibodies  Synthesis And Interconversion Of Nucleotide Di- And Triphosphates Pathway Diagram

Diseases associated with anti-DTYMK antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >4 publications with DTYMK and Neoplasms
 Carcinoma Antibodies  >2 publications with DTYMK and Carcinoma
 Colorectal Neoplasms Antibodies  >2 publications with DTYMK and Colorectal Neoplasms
 Mouth Neoplasms Antibodies  >1 publications with DTYMK and Mouth Neoplasms
 Liver Diseases Antibodies  >1 publications with DTYMK and Liver Diseases
 Carcinoma, Squamous Cell Antibodies  >1 publications with DTYMK and Carcinoma, Squamous Cell
 Head and Neck Neoplasms Antibodies  >1 publications with DTYMK and Head and Neck Neoplasms
 Neoplasm Metastasis Antibodies  >1 publications with DTYMK and Neoplasm Metastasis
 Adenocarcinoma Antibodies  >1 publications with DTYMK and Adenocarcinoma
 Liver Neoplasms Antibodies  >1 publications with DTYMK and Liver Neoplasms

Organs/Tissues associated with anti-DTYMK antibody

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >1 publications with DTYMK and Liver
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