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ALDH3B1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS624755

The aldehyde dehydrogenases are a family of isozymes that may play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. More details

$895 / 0.2 mL +1 FREE 8GB USB
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Testing Data View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
ALDH3B1, Polyclonal Antibody
Full Product Name
ALDH3B1, ID (Aldehyde Dehydrogenase Family 3 Member B1, Aldehyde Dehydrogenase 7, ALDH7)
Product Gene Name
anti-ALDH3B1 antibody
Product Synonym Names
Anti -ALDH3B1, ID (Aldehyde Dehydrogenase Family 3 Member B1, Aldehyde Dehydrogenase 7, ALDH7)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, 0.09% sodium azide.
Purity/Purification
Affinity Purified
Purified by immunoaffinity chromatography.
Specificity
Recognizes human ALDH3B.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
51,840 Da
Chromosome Location
Chromosome: 11; NC_000011.9 (67776048..67796743). Location: 11q13
OMIM
600466
3D Structure
ModBase 3D Structure for P43353
Immunogen
Synthetic peptide selected from the Center region of human ALDH3B (KLH).

Product Categories/Family for anti-ALDH3B1 antibody

Antibodies; Abs to Enzymes; Dehydrogenase
Applications Tested/Suitable for anti-ALDH3B1 antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-ALDH3B1 antibody
Suitable for use in ELISA and Western Blot.
Dilution: ELISA: 1:1,000
Western Blot: 1:100-1:500

Western Blot (WB) of anti-ALDH3B1 antibody

Western blot analysis of ALDH3B1 Antibody (Center) in MDA-MB231 cell line lysates (35ug/lane). ALDH3B1 (arrow) was detected using the purified Pab.
Rabbit Anti-ALDH3B1 Polyclonal Antibody – Cat# MBS624755

Western Blot (WB) of anti-ALDH3B1 antibody

Western blot analysis of ALDH3B1 (arrow) using rabbit polyclonal ALDH3B1 Antibody (Center) . 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the ALDH3B1 gene.
Rabbit Anti-ALDH3B1 Polyclonal Antibody, Western Blot (WB) – Cat# MBS624755

Immunohistochemistry (IHC) of anti-ALDH3B1 antibody

Formalin-fixed and paraffin-embedded human lung carcinoma reacted with ALDH3B1 Antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Rabbit Anti-ALDH3B1 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS624755

Other Notes

Small volumes of anti-ALDH3B1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ALDH3B1 purchase

MBS624755 is an antibody targeting ALDH3B1. Also known as ALDH3B1, ID (Aldehyde Dehydrogenase Family 3 Member B1, Aldehyde Dehydrogenase 7, ALDH7). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for ALDH3B1. It may not necessarily be applicable to this product.

NCBI GI #
71773324
NCBI GeneID
221
NCBI Accession #
NP_001025181.1
UniProt Primary Accession #
P43353
UniProt Secondary Accession #
Q53XL5; Q8N515; Q96CK8
UniProt Related Accession #
P43353; Q59F10; Q9BUJ8
GenBank Nucleotide #
NM_001030010.1
NCBI Official Full Name
aldehyde dehydrogenase family 3 member B1 isoform b
NCBI Official Synonym Full Names
aldehyde dehydrogenase 3 family, member B1
NCBI Official Symbol
ALDH3B1
NCBI Official Synonym Symbols
ALDH4; ALDH7; FLJ26433; FLJ34710
UniProt Protein Name
Aldehyde dehydrogenase family 3 member B1
UniProt Synonym Protein Names
Aldehyde dehydrogenase 7
Protein Family
Aldehyde dehydrogenase family
UniProt Gene Name
ALDH3B1
UniProt Synonym Gene Names
ALDH7
UniProt Entry Name
AL3B1_HUMAN
NCBI Protein Information
aldehyde dehydrogenase family 3 member B1; aldehyde dehydrogenase 7; aldehyde dehydrogenase 3B1

NCBI Summary for ALDH3B1

The aldehyde dehydrogenases are a family of isozymes that may play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. This particular gene spans about 20 kb of genomic DNA and is composed of 9 coding exons. The gene is highly expressed in kidney and lung. The functional significance of this gene as well as the cellular localization of its product are presently unknown. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
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UniProt Comments for ALDH3B1

ALDH3B1: Oxidizes medium and long chain saturated and unsaturated aldehydes. Metabolizes also benzaldehyde. Low activity towards acetaldehyde and 3,4-dihydroxyphenylacetaldehyde. May not metabolize short chain aldehydes. May use both NADP(+) and NAD(+) as cofactors. May have a protective role against the cytotoxicity induced by lipid peroxidation. Belongs to the aldehyde dehydrogenase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 1.2.1.5; Xenobiotic Metabolism - metabolism by cytochrome P450; Amino Acid Metabolism - histidine; Amino Acid Metabolism - phenylalanine; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Amino Acid Metabolism - tyrosine; Oxidoreductase

Chromosomal Location of Human Ortholog: 11q13

Cellular Component: cytoplasm; plasma membrane; cytosol; vesicle

Molecular Function: aldehyde dehydrogenase [NAD(P)+] activity; 3-chloroallyl aldehyde dehydrogenase activity

Biological Process: aldehyde catabolic process; ethanol catabolic process; alcohol metabolic process; lipid metabolic process
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Research Articles on ALDH3B1

1. protects cells from the damaging effects of oxidative stress

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-ALDH3B1 antibody

 Products by Pathway  Pathway Diagram
 Drug Metabolism - Cytochrome P450 Pathway antibodies  Drug Metabolism - Cytochrome P450 Pathway Diagram
 Drug Metabolism - Cytochrome P450 Pathway antibodies  Drug Metabolism - Cytochrome P450 Pathway Diagram
 Glycolysis / Gluconeogenesis Pathway antibodies  Glycolysis / Gluconeogenesis Pathway Diagram
 Glycolysis / Gluconeogenesis Pathway antibodies  Glycolysis / Gluconeogenesis Pathway Diagram
 Histidine Metabolism Pathway antibodies  Histidine Metabolism Pathway Diagram
 Histidine Metabolism Pathway antibodies  Histidine Metabolism Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Of Xenobiotics By Cytochrome P450 Pathway antibodies  Metabolism Of Xenobiotics By Cytochrome P450 Pathway Diagram
 Metabolism Of Xenobiotics By Cytochrome P450 Pathway antibodies  Metabolism Of Xenobiotics By Cytochrome P450 Pathway Diagram
 Phenylalanine Metabolism Pathway antibodies  Phenylalanine Metabolism Pathway Diagram

Diseases associated with anti-ALDH3B1 antibody

 Disease Name  Pubmed Publications
 Colorectal Neoplasms Antibodies  >1 publications with ALDH3B1 and Colorectal Neoplasms
 Breast Neoplasms Antibodies  >1 publications with ALDH3B1 and Breast Neoplasms
 Kidney Diseases Antibodies  >1 publications with ALDH3B1 and Kidney Diseases
 Ovarian Neoplasms Antibodies  >1 publications with ALDH3B1 and Ovarian Neoplasms
 Neoplasms Antibodies  >1 publications with ALDH3B1 and Neoplasms
 Liver Diseases Antibodies  >1 publications with ALDH3B1 and Liver Diseases
 Gonadal Disorders Antibodies  >1 publications with ALDH3B1 and Gonadal Disorders
 Lung Neoplasms Antibodies  >1 publications with ALDH3B1 and Lung Neoplasms

Organs/Tissues associated with anti-ALDH3B1 antibody

 Organ/Tissue Name  Pubmed Publications
 Testis Antibodies  >3 publications with ALDH3B1 and Testis
 Lung Antibodies  >3 publications with ALDH3B1 and Lung
 Eye Antibodies  >2 publications with ALDH3B1 and Eye
 Kidney Antibodies  >2 publications with ALDH3B1 and Kidney
 Brain Antibodies  >1 publications with ALDH3B1 and Brain
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