• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

CX3CR1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS625075

CX3CR1 is one of the chemokine receptors that are required as coreceptors for HIV infection. The genes encoding human, mouse, and rat CX3 CR1 were cloned and designated V28 and CMKBRL1, CX3CR1, and RBS11, respectively. The encoded seven transmembrane protein… More details

$1155 / 0.1 mg +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CX3CR1, EL, Polyclonal Antibody
Full Product Name
CX3CR1, EL (Beta Chemokine Receptor-like 1, CCRL1, Chemokine C-X3-C Motif Receptor 1, CX3C Chemokine Receptor 1, C-X3-C CKR-1, CX3C CKR-1, CMK-BRL-1, CMKBLR1, CMKDR1, Fractalkine Receptor, GPR13, GPRV28, V28)
Product Gene Name
anti-CX3CR1 antibody
Product Synonym Names
Anti -CX3CR1, EL (Beta Chemokine Receptor-like 1, CCRL1, Chemokine C-X3-C Motif Receptor 1, CX3C Chemokine Receptor 1, C-X3-C CKR-1, CX3C CKR-1, CMK-BRL-1, CMKBLR1, CMKDR1, Fractalkine Receptor, GPR13, GPRV28, V28)
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, 0.02% sodium azide.
Purity/Purification
Affinity Purified
Purified by immunoaffinity chromatography.
Specificity
Recognizes human CX3CR1, extracellular loop. Species sequence homology: mouse, rat.
Preparation and Storage
May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight
40,396 Da
Chromosome Location
Chromosome: 3; NC_000003.11 (39304985..39323226, complement). Location: 3p21; 3p21.3
OMIM
601470
3D Structure
ModBase 3D Structure for P49238
Immunogen
Peptide corresponding to aa175-189 of human CX3CR1.

Product Categories/Family for anti-CX3CR1 antibody

Antibodies; Abs to Growth Factors; Cytokines
Applications Tested/Suitable for anti-CX3CR1 antibody
Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-CX3CR1 antibody
Suitable for use in Western Blot and Immunohistochemistry.
Dilution: Western Blot: 1:500
Immunohistochemistry: 10ug/ml

Other Notes

Small volumes of anti-CX3CR1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CX3CR1 purchase

MBS625075 is an antibody targeting CX3CR1. Also known as CX3CR1, EL (Beta Chemokine Receptor-like 1, CCRL1, Chemokine C-X3-C Motif Receptor 1, CX3C Chemokine Receptor 1, C-X3-C CKR-1, CX3C CKR-1, CMK-BRL-1, CMKBLR1, CMKDR1, Fractalkine Receptor, GPR13, GPRV28, V28). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CX3CR1. It may not necessarily be applicable to this product.

NCBI GI #
1351394
NCBI GeneID
1524
UniProt Primary Accession #
P49238
UniProt Secondary Accession #
A0N0N6; B2R5Z4
UniProt Related Accession #
P49238
NCBI Official Full Name
CX3C chemokine receptor 1
NCBI Official Synonym Full Names
chemokine (C-X3-C motif) receptor 1
NCBI Official Symbol
CX3CR1
NCBI Official Synonym Symbols
V28; CCRL1; GPR13; CMKDR1; GPRV28; CMKBRL1
UniProt Protein Name
CX3C chemokine receptor 1
UniProt Synonym Protein Names
Beta chemokine receptor-like 1; CMK-BRL-1; CMK-BRL1; Fractalkine receptor; G-protein coupled receptor 13; V28
Protein Family
CX3C chemokine receptor
UniProt Gene Name
CX3CR1
UniProt Synonym Gene Names
CMKBRL1; GPR13
UniProt Entry Name
CX3C1_HUMAN
NCBI Protein Information
CX3C chemokine receptor 1; CMK-BRL1; CMK-BRL-1; C-X3-C CKR-1; OTTHUMP00000209587; OTTHUMP00000209588; OTTHUMP00000209589; fractalkine receptor; G protein-coupled receptor 13; G-protein coupled receptor 13; chemokine (C-X3-C) receptor 1; beta chemokine receptor-like 1; chemokine (C-C) receptor-like 1

NCBI Summary for CX3CR1

Fractalkine is a transmembrane protein and chemokine involved in the adhesion and migration of leukocytes. The protein encoded by this gene is a receptor for fractalkine. The encoded protein also is a coreceptor for HIV-1, and some variations in this gene lead to increased susceptibility to HIV-1 infection and rapid progression to AIDS. Four transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq]
Show more

UniProt Comments for CX3CR1

CX3CR1: Receptor for the CX3C chemokine fractalkine and mediates both its adhesive and migratory functions. Acts as coreceptor with CD4 for HIV-1 virus envelope protein (in vitro). Isoform 2 and isoform 3 seem to be more potent HIV-1 coreceptors than isoform 1. Defects in CX3CR1 are a cause of susceptibility to age- related macular degeneration type 12 (ARMD12). ARMD12 is a form of age-related macular degeneration, a multifactorial eye disease and the most common cause of irreversible vision loss in the developed world. In most patients, the disease is manifest as ophthalmoscopically visible yellowish accumulations of protein and lipid that lie beneath the retinal pigment epithelium and within an elastin-containing structure known as Bruch membrane. Belongs to the G-protein coupled receptor 1 family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: GPCR, family 1; Receptor, cytokine; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Receptor, GPCR; Membrane protein, integral; Cell adhesion

Chromosomal Location of Human Ortholog: 3p21.3

Cellular Component: neuron projection; integral to plasma membrane; perinuclear region of cytoplasm; plasma membrane

Molecular Function: protein binding; chemokine receptor activity; C-X3-C chemokine receptor activity

Biological Process: G-protein coupled receptor protein signaling pathway; positive regulation of angiogenesis; negative regulation of angiogenesis; cerebral cortex cell migration; viral reproduction; response to wounding; cellular defense response; cell adhesion; chemotaxis; macrophage chemotaxis; negative regulation of cell migration; microglial cell activation during immune response

Disease: Macular Degeneration, Age-related, 12; Coronary Heart Disease, Susceptibility To, 1; Human Immunodeficiency Virus Type 1, Susceptibility To
Show more

Research Articles on CX3CR1

1. CX3CL1-CX3CR1 is a novel inflammatory adipose chemokine system that modulates monocyte adhesion to adipocytes and is associated with obesity, insulin resistance, and type 2 diabetes.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CX3CR1 antibody

 Reference Product  PubMed Publications
 CX3CL1 antibody  >281 publications with CX3CR1 and CX3CL1

Pathways associated with anti-CX3CR1 antibody

 Products by Pathway  Pathway Diagram
 Chemokine Receptors Bind Chemokines Pathway antibodies  Chemokine Receptors Bind Chemokines Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 GPCRs, Class A Rhodopsin-like Pathway antibodies  GPCRs, Class A Rhodopsin-like Pathway Diagram
 Peptide GPCRs Pathway antibodies  Peptide GPCRs Pathway Diagram
 Peptide Ligand-binding Receptors Pathway antibodies  Peptide Ligand-binding Receptors Pathway Diagram

Diseases associated with anti-CX3CR1 antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >169 publications with CX3CR1 and Inflammation
 Immune System Diseases Antibodies  >109 publications with CX3CR1 and Immune System Diseases
 Neoplasms Antibodies  >54 publications with CX3CR1 and Neoplasms
 Arteriosclerosis Antibodies  >50 publications with CX3CR1 and Arteriosclerosis
 Pain Antibodies  >33 publications with CX3CR1 and Pain
 Macular Degeneration Antibodies  >32 publications with CX3CR1 and Macular Degeneration
 Coronary Disease Antibodies  >31 publications with CX3CR1 and Coronary Disease
 Liver Diseases Antibodies  >13 publications with CX3CR1 and Liver Diseases
 Neuroectodermal Tumors Antibodies  >12 publications with CX3CR1 and Neuroectodermal Tumors
 Diabetes Mellitus Antibodies  >11 publications with CX3CR1 and Diabetes Mellitus

Organs/Tissues associated with anti-CX3CR1 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >276 publications with CX3CR1 and Blood
 Brain Antibodies  >89 publications with CX3CR1 and Brain
 Kidney Antibodies  >41 publications with CX3CR1 and Kidney
 Lung Antibodies  >40 publications with CX3CR1 and Lung
 Spinal Cord Antibodies  >33 publications with CX3CR1 and Spinal Cord
 Liver Antibodies  >20 publications with CX3CR1 and Liver
 Spleen Antibodies  >10 publications with CX3CR1 and Spleen
 Thymus Antibodies  >7 publications with CX3CR1 and Thymus
 Pancreas Antibodies  >6 publications with CX3CR1 and Pancreas
 Connective Tissue Antibodies  >6 publications with CX3CR1 and Connective Tissue
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000