Rat Anti-DECTIN1 Monoclonal Antibody – Cat# MBS6251766

Staining of mouse peritoneal macrophages with RAT ANTI MOUSE BETA-GLUCAN RECEPTOR: FITC

Dectin-1 (DECTIN1) Antibody – Rat Monoclonal

Name: DECTIN1 Antibody; Monoclonal; Rat; Mouse-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS6251766
Price: 1095 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6251766

MBS6251766 is an antibody targeting DECTIN1. Also known as Dectin-1 (C-type Lectin Domain Family 7 Member A, Dendritic Cell-associated C-type Lectin 1, DC-associated C-type Lectin 1, Beta-glucan Receptor, beta-GR, C-type Lectin Superfamily Member 12, CLEC7A,… More details

$1095 / 0.1 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Dectin-1 (DECTIN1), Monoclonal Antibody

Full Product Name

Dectin-1 (C-type Lectin Domain Family 7 Member A, Dendritic Cell-associated C-type Lectin 1, DC-associated C-type Lectin 1, Beta-glucan Receptor, beta-GR, C-type Lectin Superfamily Member 12, CLEC7A, BGR, CLECSF12, DECTIN1, UNQ539/PRO1082) (PE)

Product Gene Name

anti-DECTIN1 antibody

Clonality

Monoclonal

Isotype

IgG2b

Clone Number

10B2689

Host

Rat

Species Reactivity

Mouse

Form/Format

Supplied as a liquid in PBS, pH 7.2. Labeled with R-Phycoerythrin (PE).

Purity/Purification

Purified by Protein G Affinity Chromatography

Specificity

Recognizes mouse Dectin-1. Dectin-1 is predominantly expressed by cells of the monocyte/macrophage and neutrophil lineages, but also at lower levels by dendritic cells and a subpopulation of T cells.

Preparation and Storage

Store at 4 degree C. Do Not Freeze.

Molecular Weight

21.0kDa (183aa) 18-28KDa (SDS-PAGE under reducing conditions.)

3D Structure

ModBase 3D Structure for Q6QLQ4

Immunogen

Dectin-1 transfected NIH3T3 cells and recombinant soluble Dectin-1. UniProt Accession #: Q6QLQ4

Conjugate

Product Categories/Family for anti-DECTIN1 antibody

Antibodies; Lectins

Applications Tested/Suitable for anti-DECTIN1 antibody

Flow Cytometry (FC/FACS), Immunohistochemistry (IHC), Immunoprecipitation (IP)

Product References and Citations for anti-DECTIN1 antibody

1. Brown, G. D. et al. (2002) Dectin-1 is a major beta-glucan receptor on macrophages. J. Exp. Med. 196:407-412.2. Taylor, P. R. et al. (2002) The beta-glucan receptor, Dectin-1 is predominantly expressed on the surface of cells of the monocyte/macrophage and neutrophil lineages. J. Immunol. 169:3876-3882.3. Reid, D.M. et al. (2004) Expression of the beta-glucan receptor, Dectin-1, on murine leukocytes in situ correlates with its function in pathogen recognition and reveals potential roles in leukocyte interactions. J. Leuk. Biol. 76:86-94.4. Underhill, D.M. et al. (2005) Dectin-1 activates Syk tyrosine kinase in a dynamic subset of macrophages for reactive oxygen production. Blood 106:2543-2550.

Other Notes

Small volumes of anti-DECTIN1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for DECTIN1. It may not necessarily be applicable to this product.

NCBI GI #

188035930

NCBI GeneID

56644

NCBI Accession #

NP_064392

UniProt Primary Accession #

Q6QLQ4

UniProt Secondary Accession #

Q8K1L4; Q9JI50; E9QPW2

UniProt Related Accession #

Q6QLQ4

GenBank Nucleotide #

NM_020008.3

NCBI Official Full Name

C-type lectin domain family 7 member A 1

NCBI Official Synonym Full Names

C-type lectin domain family 7, member a

NCBI Official Symbol

Clec7a

NCBI Official Synonym Symbols

BGR; beta-GR; Clecsf12

UniProt Protein Name

C-type lectin domain family 7 member A

UniProt Synonym Protein Names

Beta-glucan receptor; C-type lectin superfamily member 12; Dendritic cell-associated C-type lectin 1; DC-associated C-type lectin 1; Dectin-1

Protein Family

C-type lectin domain family

UniProt Gene Name

Clec7a

UniProt Synonym Gene Names

Bgr; Clecsf12; Dectin1; DC-associated C-type lectin 1; Dectin-1

NCBI Protein Information

C-type lectin domain family 7 member A

UniProt Comments for DECTIN1

Lectin that functions as pattern receptor specific for beta-1,3-linked and beta-1,6-linked glucans, such as cell wall constituents from pathogenic bacteria and fungi. Necessary for the TLR2-mediated inflammatory response and for TLR2-mediated activation of NF-kappa-B. Enhances cytokine production in macrophages and dendritic cells. Mediates production of reactive oxygen species in the cell. Mediates phagocytosis of C.albicans conidia. Binds T-cells in a way that does not involve their surface glycans and plays a role in T-cell activation. Stimulates T-cell proliferation.

Research Articles on DECTIN1

1. Dectin-1 agonists selectively induce IgG1 class switching by direct stimulation of Dectin-1 on LPS-activated B cells resulting in selective production of IgG1.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-DECTIN1 antibody

Products by Pathway	Pathway Diagram
C-type Lectin Receptors (CLRs) Pathway antibodies	C-type Lectin Receptors (CLRs) Pathway Diagram
CLEC7A (Dectin-1) Signaling Pathway antibodies	CLEC7A (Dectin-1) Signaling Pathway Diagram
Immune System Pathway antibodies	Immune System Pathway Diagram
Innate Immune System Pathway antibodies	Innate Immune System Pathway Diagram
Phagosome Pathway antibodies	Phagosome Pathway Diagram
Phagosome Pathway antibodies	Phagosome Pathway Diagram
Tuberculosis Pathway antibodies	Tuberculosis Pathway Diagram
Tuberculosis Pathway antibodies	Tuberculosis Pathway Diagram

Organs/Tissues associated with anti-DECTIN1 antibody

Organ/Tissue Name	Pubmed Publications
Lung Antibodies	>7 publications with DECTIN1 and Lung
Skin Antibodies	>5 publications with DECTIN1 and Skin
Bone Marrow Antibodies	>5 publications with DECTIN1 and Bone Marrow
Spleen Antibodies	>4 publications with DECTIN1 and Spleen
Lymph Node Antibodies	>2 publications with DECTIN1 and Lymph Node
Uterus Antibodies	>1 publications with DECTIN1 and Uterus
Thymus Antibodies	>1 publications with DECTIN1 and Thymus