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CD59 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Special Promotion Catalog #: MBS9132305
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This gene encodes a cell surface glycoprotein that regulates complement-mediated cell lysis, and it is involved in lymphocyte signal transduction. This protein is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8… More details

$225 / 0.02 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CD59, Polyclonal Antibody
Full Product Name
CD59 Polyclonal Antibody
Product Gene Name
anti-CD59 antibody
Product Synonym Names
16.3A5; 1F5; EJ16; EJ30; EL32; G344; HRF-20; HRF20; MAC-IP; MACIF; MEM43; MIC11; MIN1; MIN2; MIN3; MIRL; MSK21; p18-20
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Purity/Purification
Affinity Purification
Preparation and Storage
Store at -20 degree C. Avoid freeze/thaw cycles.
Molecular Weight
14kDa
OMIM
M27909 mRNA
3D Structure
ModBase 3D Structure for P13987
Immunogen
Recombinant protein of human CD59
Storage Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Product Categories/Family for anti-CD59 antibody

Primary antibody
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-CD59 antibody
Western Blot (WB)
Application Notes for anti-CD59 antibody
WB: 1:500 - 2000

Western Blot (WB) of anti-CD59 antibody

Western blot analysis of extracts of various cell lines, using CD59 antibody at 1:1000 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Enhanced Kit.
Exposure time: 90s.
Rabbit Anti-CD59 Polyclonal Antibody – Cat# MBS9132305

Other Notes

Small volumes of anti-CD59 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CD59 purchase

MBS9132305 is an antibody targeting CD59. Also known as CD59 Polyclonal Antibody. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CD59. It may not necessarily be applicable to this product.

NCBI GI #
116021
NCBI GeneID
966
NCBI Accession #
P13987.1
UniProt Primary Accession #
P13987
UniProt Related Accession #
P13987
NCBI Official Full Name
CD59 glycoprotein
NCBI Official Synonym Full Names
CD59 molecule (CD59 blood group)
NCBI Official Symbol
CD59
NCBI Official Synonym Symbols
1F5; EJ16; EJ30; EL32; G344; MIN1; MIN2; MIN3; MIRL; HRF20; MACIF; MEM43; MIC11; MSK21; 16.3A5; HRF-20; MAC-IP; p18-20
UniProt Protein Name
CD59 glycoprotein
UniProt Synonym Protein Names
1F5 antigen; 20 kDa homologous restriction factor; HRF-20; HRF20; MAC-inhibitory protein; MAC-IP; MEM43 antigen; Membrane attack complex inhibition factor; MACIF; Membrane inhibitor of reactive lysis; MIRL; Protectin; CD_antigen: CD59
Protein Family
CD59 glycoprotein
UniProt Gene Name
CD59
UniProt Synonym Gene Names
MIC11; MIN1; MIN2; MIN3; MSK21; HRF-20; HRF20; MAC-IP; MACIF; MIRL
NCBI Protein Information
CD59 glycoprotein

UniProt Comments for CD59

CD59: Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. Involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase. Defects in CD59 are the cause of CD59 deficiency (CD59D).

Protein type: Membrane protein, GPI anchor

Chromosomal Location of Human Ortholog: 11p13

Cellular Component: anchored to external side of plasma membrane; cell surface; endoplasmic reticulum membrane; ER-Golgi intermediate compartment membrane; extracellular space; focal adhesion; Golgi membrane; membrane; plasma membrane; vesicle

Molecular Function: complement binding; protein binding

Biological Process: blood coagulation; cell activation; cell surface receptor linked signal transduction; COPII coating of Golgi vesicle; ER to Golgi vesicle-mediated transport; neutrophil degranulation; regulation of complement activation

Disease: Hemolytic Anemia, Cd59-mediated, With Or Without Immune-mediated Polyneuropathy
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Research Articles on CD59

1. Single-fluorescent-molecule imaging in the live-cell plasma membrane revealed the clear but transient colocalization and codiffusion of fluorescent ganglioside analogs with a fluorescently labeled glycosylphosphatidylinisotol (GPI)-anchored protein, human CD59, with lifetimes of 12 ms for CD59 monomers, 40 ms for CD59's transient homodimer rafts in quiescent cells.
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CD59 antibody

 Reference Product  PubMed Publications
 CD55 antibody  >815 publications with CD59 and CD55
 CD46 antibody  >314 publications with CD59 and CD46
 PIGA antibody  >24 publications with CD59 and PIGA
 CAV1 antibody  >5 publications with CD59 and CAV1
 C8A antibody  >1 publications with CD59 and C8A

Pathways associated with anti-CD59 antibody

 Products by Pathway  Pathway Diagram
 Arf6 Trafficking Events Pathway antibodies  Arf6 Trafficking Events Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement Cascade Pathway antibodies  Complement Cascade Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram
 Regulation Of Complement Cascade Pathway antibodies  Regulation Of Complement Cascade Pathway Diagram

Diseases associated with anti-CD59 antibody

 Disease Name  Pubmed Publications
 Anemia Antibodies  >404 publications with CD59 and Anemia
 Inflammation Antibodies  >150 publications with CD59 and Inflammation
 Necrosis Antibodies  >78 publications with CD59 and Necrosis
 Disease Models, Animal Antibodies  >75 publications with CD59 and Disease Models, Animal
 Lymphoma Antibodies  >66 publications with CD59 and Lymphoma
 Kidney Diseases Antibodies  >51 publications with CD59 and Kidney Diseases
 Adenocarcinoma Antibodies  >37 publications with CD59 and Adenocarcinoma
 Brain Diseases Antibodies  >34 publications with CD59 and Brain Diseases
 Breast Neoplasms Antibodies  >27 publications with CD59 and Breast Neoplasms
 CD59 Deficiency Antibodies  >27 publications with CD59 and CD59 Deficiency

Organs/Tissues associated with anti-CD59 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >937 publications with CD59 and Blood
 Vascular Antibodies  >202 publications with CD59 and Vascular
 Bone Antibodies  >187 publications with CD59 and Bone
 Bone Marrow Antibodies  >179 publications with CD59 and Bone Marrow
 Kidney Antibodies  >116 publications with CD59 and Kidney
 Heart Antibodies  >90 publications with CD59 and Heart
 Liver Antibodies  >75 publications with CD59 and Liver
 Muscle Antibodies  >74 publications with CD59 and Muscle
 Lung Antibodies  >67 publications with CD59 and Lung
 Brain Antibodies  >61 publications with CD59 and Brain
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