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Inositol Polyphosphate 4-Phosphatase Type II (INPP4B) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS625604

INPP4B catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate. More details

$895 / 0.2 mL +1 FREE 8GB USB
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Testing Data View PDF
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Product Overview

Online Datasheet in PDF
Product Name
Inositol Polyphosphate 4-phosphatase Type II (INPP4B), Polyclonal Antibody
Full Product Name
Inositol Polyphosphate 4-phosphatase Type II (Inositol Polyphosphate-4-phosphatase Type II 105kDa, INPP4B, MGC132014, Type II Inositol-3,4-bisphosphate 4-phosphatase)
Product Gene Name
anti-INPP4B antibody
Product Synonym Names
Anti -Inositol Polyphosphate 4-phosphatase Type II (Inositol Polyphosphate-4-phosphatase Type II 105kDa, INPP4B, MGC132014, Type II Inositol-3,4-bisphosphate 4-phosphatase)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, 0.09% sodium azide.
Purity/Purification
Affinity Purified
Purified by immunoaffinity chromatography.
Specificity
Recognizes human INPP4B.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
104,738 Da
Chromosome Location
Chromosome: 4; NC_000004.11 (142949181..143767604, complement). Location: 4q31.21
OMIM
607494
3D Structure
ModBase 3D Structure for O15327
Immunogen
Synthetic peptide selected from the Center region of human INPP4B (KLH).

Product Categories/Family for anti-INPP4B antibody

Antibodies; Abs to Enzymes; Phosphatase
Applications Tested/Suitable for anti-INPP4B antibody
ELISA (EL/EIA), Western Blot (WB)
Application Notes for anti-INPP4B antibody
Suitable for use in ELISA and Western Blot.
Dilution: ELISA: 1:1,000
Western Blot: 1:100-1:500

Western Blot (WB) of anti-INPP4B antibody

Western blot analysis of INPP4B Antibody (Center) in MCF-7 cell line lysates (35ug/lane). INPP4B (arrow) was detected using the purified Pab.
Rabbit Anti-INPP4B Polyclonal Antibody – Cat# MBS625604

Immunohistochemistry (IHC) of anti-INPP4B antibody

Formalin-fixed and paraffin-embedded human brain tissue reacted with INPP4B Antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Rabbit Anti-INPP4B Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS625604

Flow Cytometry (FC/FACS) of anti-INPP4B antibody

INPP4B Antibody (Center) flow cytometric analysis of k562 cells (bottom histogram) compared to a negative control cell (top histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Rabbit Anti-INPP4B Polyclonal Antibody, Flow Cytometry (FC/FACS) – Cat# MBS625604

Other Notes

Small volumes of anti-INPP4B antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for INPP4B purchase

MBS625604 is an antibody targeting INPP4B. Also known as Inositol Polyphosphate 4-phosphatase Type II (Inositol Polyphosphate-4-phosphatase Type II 105kDa, INPP4B, MGC132014, Type II Inositol-3,4-bisphosphate 4-phosphatase). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for INPP4B. It may not necessarily be applicable to this product.

NCBI GI #
2232037
NCBI GeneID
8821
UniProt Primary Accession #
O15327
UniProt Secondary Accession #
Q2TAI2; Q6IN59; Q6PJB4
UniProt Related Accession #
O15327; Q5XLE7; Q9BS68
NCBI Official Full Name
inositol polyphosphate 4-phosphatase type II-alpha
NCBI Official Synonym Full Names
inositol polyphosphate-4-phosphatase, type II, 105kDa
NCBI Official Symbol
INPP4B
NCBI Official Synonym Symbols
MGC132014
UniProt Protein Name
Type II inositol-3,4-bisphosphate 4-phosphatase
UniProt Synonym Protein Names
Inositol polyphosphate 4-phosphatase type II
Protein Family
Type II inositol 3,4-bisphosphate 4-phosphatase
UniProt Gene Name
INPP4B
UniProt Entry Name
INP4B_HUMAN
NCBI Protein Information
type II inositol-3,4-bisphosphate 4-phosphatase; OTTHUMP00000220065; OTTHUMP00000220066; OTTHUMP00000220068; OTTHUMP00000220070; OTTHUMP00000220071; inositol polyphosphate 4-phosphatase type II; inositol polyphosphate 4-phosphatase II; 4-phosphatase II

NCBI Summary for INPP4B

INPP4B encodes the inositol polyphosphate 4-phosphatase type II, one of the enzymes involved in phosphatidylinositol signaling pathways. This enzyme removes the phosphate group at position 4 of the inositol ring from inositol 3,4-bisphosphate. There is limited data to suggest that the human type II enzyme is subject to alternative splicing, as has been established for the type I enzyme. [provided by RefSeq]
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UniProt Comments for INPP4B

INPP4B: Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4- trisphosphate and inositol 1,4-bisphosphate. Widely expressed with highest levels occurring in the skeletal muscle and heart. Strongly inhibited by inositol hexakisphosphate. Belongs to the inositol 3,4-bisphosphate 4-phosphatase family.

Protein type: EC 3.1.3.66; Phosphatase, lipid; Motility/polarity/chemotaxis; Carbohydrate Metabolism - inositol phosphate

Chromosomal Location of Human Ortholog: 4q31.21

Cellular Component: Golgi apparatus; cytosol

Molecular Function: phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity; lipid binding

Biological Process: cellular calcium ion homeostasis; negative regulation of osteoclast differentiation; inositol phosphate metabolic process; dephosphorylation; phospholipid metabolic process; regulation of nucleocytoplasmic transport; phosphatidylinositol biosynthetic process; regulation of bone remodeling; regulation of protein kinase B signaling cascade; signal transduction
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Research Articles on INPP4B

1. INPP4B functions as a tumor suppressor by negatively regulating normal and malignant mammary epithelial cell proliferation through regulation of the PI3K/Akt signaling pathway

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-INPP4B antibody

 Products by Pathway  Pathway Diagram
 3-phosphoinositide Degradation Pathway antibodies  3-phosphoinositide Degradation Pathway Diagram
 Inositol Phosphate Metabolism Pathway antibodies  Inositol Phosphate Metabolism Pathway Diagram
 Inositol Phosphate Metabolism Pathway antibodies  Inositol Phosphate Metabolism Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Phosphatidylinositol Signaling System Pathway antibodies  Phosphatidylinositol Signaling System Pathway Diagram
 Phosphatidylinositol Signaling System Pathway antibodies  Phosphatidylinositol Signaling System Pathway Diagram

Diseases associated with anti-INPP4B antibody

 Disease Name  Pubmed Publications
 Breast Neoplasms Antibodies  >2 publications with INPP4B and Breast Neoplasms
 Prostatic Neoplasms Antibodies  >1 publications with INPP4B and Prostatic Neoplasms
 Ovarian Neoplasms Antibodies  >1 publications with INPP4B and Ovarian Neoplasms
 Leukemia Antibodies  >1 publications with INPP4B and Leukemia
 Gonadal Disorders Antibodies  >1 publications with INPP4B and Gonadal Disorders

Organs/Tissues associated with anti-INPP4B antibody

 Organ/Tissue Name  Pubmed Publications
 Prostate Antibodies  >3 publications with INPP4B and Prostate
 Bone Antibodies  >1 publications with INPP4B and Bone
 Liver Antibodies  >1 publications with INPP4B and Liver
 Bone Marrow Antibodies  >1 publications with INPP4B and Bone Marrow
 Kidney Antibodies  >1 publications with INPP4B and Kidney
 Brain Antibodies  >1 publications with INPP4B and Brain
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