Apolipoprotein E (APO-E) Antibody – Mouse Monoclonal

MBS6256455 is an antibody targeting Apo-E. Also known as Apolipoprotein E (Apo-E) (MaxLight 750). Reactive in Human, Mouse. Host: Mouse.

1. Krul, E.S et al (1988) Heterogeneity of apolipoprotein E epitope expression on human lipoproteins: importance for apolipoprotein E function. J. Lipid Res. 29: 1309-1325. 2. Fryer, J.D. et al. (2005) The low density lipoprotein receptor regulates the level of central nervous system human and murine apolipoprotein E but does not modify amyloid plaque pathology in PDAPP mice. Biol. Chem. 280: 25754-25759. 3. Lee, C.Y. et al. (2012) Apolipoprotein E promotes ß-amyloid trafficking and degradation by modulating microglial cholesterol levels.J Biol Chem. 287: 2032-44. 4. Davis, R.W. et al. (1991) Lipoproteins in pinnipeds: analysis of a high molecular weight form of apolipoprotein E. J Lipid Res. 32: 1013-23. 5. Wahrle, S.E. et al. (2007) Apolipoprotein E levels in cerebrospinal fluid and the effects of ABCA1 polymorphisms. Mol Neurodegener. 2: 7. 6. Jiang, J. et al. (2012) Hepatitis C virus attachment mediated by apolipoprotein E binding to cell surface heparan sulfate. J Virol. 86: 7256-67. 7. Hirsch- Reinshagen, V. et al. (2009) LCAT synthesized by primary astrocytes esterifies cholesterol on glia-derived lipoproteins.J Lipid Res. 50: 885-93. 8. Wildsmith, K.R. et al. (2012) In Vivo Human Apolipoprotein E Isoform Fractional Turnover Rates in the CNS. 22675504 9. Jiang, J. et al. (2013) Apolipoprotein e mediates attachment of clinical hepatitis C virus to hepatocytes by binding to cell surface heparan sulfate proteoglycan receptors. PLoS One. 8: e67982. 10. Youmans, K.L. et al. (2011) Amyloid-ß42 alters apolipoprotein E solubility in brains of mice with five familial AD mutations. J Neurosci Methods. 196: 51-9. 11. Fan, J. et al. (2011) An ABCA1-independent pathway for recycling a poorly lipidated 8.1 nm apolipoprotein E particle from glia. J Lipid Res. 52: 1605-16. 12. Fagan, A.M. et al. (2004) ApoAI deficiency results in marked reductions in plasma cholesterol but no alterations in amyloid-beta pathology in a mouse model of Alzheimer's disease-like cerebral amyloidosis. Am J Pathol. 165: 1413-22. 13. Kim, J. et al. (2012) Anti-apoE immunotherapy inhibits amyloid accumulation in a transgenic mouse model of Aß amyloidosis. Exp Med. 209: 2149-56.

Small volumes of anti-Apo-E antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.