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SENP5 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS625862

MBS625862 is an antibody targeting SENP5. Also known as SENP5, CT (Sentrin-specific protease 5, Sentrin/SUMO-specific protease SENP5, FKSG45). Reactive in Human. Host: Rabbit. More details

$895 / 0.2 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
SENP5, Polyclonal Antibody
Full Product Name
SENP5, CT (Sentrin-specific protease 5, Sentrin/SUMO-specific protease SENP5, FKSG45)
Product Gene Name
Product Synonym Names
Anti -SENP5, CT (Sentrin-specific protease 5, Sentrin/SUMO-specific protease SENP5, FKSG45)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, 0.09% sodium azide.
Purity/Purification
Affinity Purified
Purified by Protein G affinity chromatography.
Specificity
Recognizes human SENP5.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
86,693 Da
Chromosome Location
Chromosome: 3; NC_000003.11 (196594727..196661585). Location: 3q29
OMIM
612845
3D Structure
ModBase 3D Structure for Q96HI0
Immunogen
Synthetic peptide selected from the C-terminal region of human SENP5 (KLH).

Product Categories/Family for anti-SENP5 antibody

Applications Tested/Suitable for anti-SENP5 antibody
ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-SENP5 antibody
Suitable for use in ELISA, Western Blot, and Immunohistochemistry.
Dilution: ELISA: 1:1,000
Western Blot: 1:100-1:500
Immunohistochemistry: 1:50-1:100

Western Blot (WB) of anti-SENP5 antibody

Western blot analysis of SENP5 polyclonal antibody in Saos-2 cell lysate. SENP5 (Arrow) was detected using purified Pab. Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence.
Rabbit Anti-SENP5 Polyclonal Antibody – Cat# MBS625862

Immunohistochemistry (IHC) of anti-SENP5 antibody

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
Rabbit Anti-SENP5 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS625862

Immunohistochemistry (IHC) of anti-SENP5 antibody

Formalin-fixed and paraffin-embedded human lung carcinoma tissue reacted with SENP5 Antibody (C-term) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Rabbit Anti-SENP5 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS625862

Other Notes

Small volumes of anti-SENP5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for SENP5. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
sentrin-specific protease 5
NCBI Official Synonym Full Names
SUMO1/sentrin specific peptidase 5
NCBI Official Symbol
SENP5
NCBI Official Synonym Symbols
FLJ42398; MGC27076; DKFZp564O1016
UniProt Protein Name
Sentrin-specific protease 5
UniProt Synonym Protein Names
Sentrin/SUMO-specific protease SENP5
UniProt Gene Name
SENP5
UniProt Entry Name
SENP5_HUMAN
NCBI Protein Information
sentrin-specific protease 5; OTTHUMP00000208184; OTTHUMP00000208185; OTTHUMP00000208186; SUMO1/sentrin specific protease 5; sentrin/SUMO-specific protease SENP5

NCBI Summary for SENP5

The reversible posttranslational modification of proteins by the addition of small ubiquitin-like SUMO proteins (see SUMO1; MIM 601912) is required for numerous biologic processes. SUMO-specific proteases, such as SENP5, are responsible for the initial processing of SUMO precursors to generate a C-terminal diglycine motif required for the conjugation reaction. They also have isopeptidase activity for the removal of SUMO from high molecular mass SUMO conjugates (Di Bacco et al., 2006 [PubMed 16738315]).[supplied by OMIM]
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UniProt Comments for SENP5

SENP5: Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO3 to its mature form and deconjugation of SUMO2 and SUMO3 from targeted proteins. Has weak proteolytic activity against full-length SUMO1 or SUMO1 conjugates. Required for cell division. Belongs to the peptidase C48 family.

Protein type: Protease; EC 3.4.22.68; Nucleolus

Chromosomal Location of Human Ortholog: 3q29

Cellular Component: nucleoplasm; intracellular membrane-bound organelle; nucleolus; nucleus

Molecular Function: protein binding; cysteine-type peptidase activity

Biological Process: cellular protein metabolic process; protein sumoylation; cell division; post-translational protein modification; proteolysis; cell cycle
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with anti-SENP5 antibody

 Disease Name  Pubmed Publications
 Weight Loss Antibodies  >1 publications with SENP5 and Weight Loss
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