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PAK4 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS626216

PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. PAK proteins, a family of serine/threonine p21-activating kinases, include PAK1, PAK2, PAK3, PAK4, PAK5, and PAK6. PAK proteins serve as targets… More details

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Product Overview

Online Datasheet in PDF
Product Name
PAK4, Polyclonal Antibody
Full Product Name
PAK4, NT (p21 Activated Kinase 4, p21-activated Kinase 4, p21(CDKN1A)-activated Kinase 4, PAK-4, KIAA1142, Protein Kinase Related to S. cerevisiae STE20 Effector for Cdc42Hs, Serine/threonine Protein Kinase PAK 4)
Product Gene Name
anti-PAK4 antibody
Product Synonym Names
Anti -PAK4, NT (p21 Activated Kinase 4, p21-activated Kinase 4, p21(CDKN1A)-activated Kinase 4, PAK-4, KIAA1142, Protein Kinase Related to S. cerevisiae STE20 Effector for Cdc42Hs, Serine/threonine Protein Kinase PAK 4)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
Supplied as a liquid in PBS, 0.09% sodium azide.
Purity/Purification
Affinity Purified
Purified by Protein G affinity chromatography.
Specificity
Recognizes human PAK4. Species Crossreactivity: mouse.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
64,072 Da
Chromosome Location
Chromosome: 19; NC_000019.9 (39616420..39670046). Location: 19q13.2
OMIM
605451
3D Structure
ModBase 3D Structure for O96013
Immunogen
Synthetic peptide selected from the N-terminal region of human PAK4 (KLH).

Product Categories/Family for anti-PAK4 antibody

Antibodies; Abs to Protein Kinases
Applications Tested/Suitable for anti-PAK4 antibody
ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-PAK4 antibody
Suitable for use in ELISA, Western Blot, and Immunohistochemistry.
Dilution: ELISA: 1:1,000
Western Blot: 1:100-1:500
Immunohistochemistry: 1:50-1:100

Immunohistochemistry (IHC) of anti-PAK4 antibody

Formalin-fixed and paraffin-embedded human prostata carcinoma tissue reacted with PAK4 antibody (N-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Rabbit Anti-PAK4 Polyclonal Antibody – Cat# MBS626216

Western Blot (WB) of anti-PAK4 antibody

The anti-PAK4 Pab is used in Western blot to detect PAK4 in mouse small intestine tissue lysate.
Rabbit Anti-PAK4 Polyclonal Antibody, Western Blot (WB) – Cat# MBS626216

Other Notes

Small volumes of anti-PAK4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PAK4 purchase

MBS626216 is an antibody targeting PAK4. Also known as PAK4, NT (p21 Activated Kinase 4, p21-activated Kinase 4, p21(CDKN1A)-activated Kinase 4, PAK-4, KIAA1142, Protein Kinase Related to S. cerevisiae STE20 Effector for Cdc42Hs, Serine/threonine Protein Kinase PAK 4). Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for PAK4. It may not necessarily be applicable to this product.

NCBI GI #
4164385
NCBI GeneID
10298
UniProt Primary Accession #
O96013
UniProt Secondary Accession #
Q8N4E1; Q8NCH5; Q8NDE3; Q9BU33; Q9ULS8; B4DGG6
UniProt Related Accession #
O96013
NCBI Official Full Name
PAK4 protein
NCBI Official Synonym Full Names
p21 protein (Cdc42/Rac)-activated kinase 4
NCBI Official Symbol
PAK4
UniProt Protein Name
Serine/threonine-protein kinase PAK 4
UniProt Synonym Protein Names
p21-activated kinase 4
Protein Family
Serine/threonine-protein kinase
UniProt Gene Name
PAK4
UniProt Synonym Gene Names
KIAA1142
UniProt Entry Name
PAK4_HUMAN
NCBI Protein Information
serine/threonine-protein kinase PAK 4; PAK-4; p21-activated kinase 4; p21(CDKN1A)-activated kinase 4; protein kinase related to S. cerevisiae STE20, effector for Cdc42Hs

NCBI Summary for PAK4

PAK proteins, a family of serine/threonine p21-activating kinases, include PAK1, PAK2, PAK3 and PAK4. PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. They serve as targets for the small GTP binding proteins Cdc42 and Rac and have been implicated in a wide range of biological activities. PAK4 interacts specifically with the GTP-bound form of Cdc42Hs and weakly activates the JNK family of MAP kinases. PAK4 is a mediator of filopodia formation and may play a role in the reorganization of the actin cytoskeleton. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq]
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UniProt Comments for PAK4

PAK4: a protein kinase of the STE20 family. A mediator of filopodia formation and may play a role in the reorganization of the actin cytoskeleton. Interacts specifically with the GTP-bound form of Cdc42 and weakly activates the JNK family of MAP kinases. Overexpressed in several cancers. Required for ras-dependent anchorage-independent growth of tumor cell lines. Four alternatively spliced human isoforms have been reported.

Protein type: Protein kinase, Ser/Thr (non-receptor); Kinase, protein; EC 2.7.11.1; Protein kinase, STE; STE group; STE20 family; PAKB subfamily

Chromosomal Location of Human Ortholog: 19q13.2

Cellular Component: Golgi apparatus; focal adhesion

Molecular Function: protein binding; ATP binding; protein kinase activity; receptor signaling protein serine/threonine kinase activity

Biological Process: cell proliferation; cell migration; apoptosis; cytoskeleton organization and biogenesis; mitotic cell cycle; cell growth; cell motility; signal transduction; protein amino acid phosphorylation
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Research Articles on PAK4

1. Findings reveal that CDK5RAP3 is widely overexpressed in hepatocellular carcinoma and that overexpression of CDK5RAP3 promotes HCC metastasis through PAK4 activation

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-PAK4 antibody

 Reference Product  PubMed Publications
 CDC42 antibody  >36 publications with PAK4 and CDC42
 LIMK1 antibody  >8 publications with PAK4 and LIMK1
 GRB2 antibody  >2 publications with PAK4 and GRB2
 FGFR2 antibody  >2 publications with PAK4 and FGFR2
 YWHAZ antibody  >1 publications with PAK4 and YWHAZ
 SSH1 antibody  >1 publications with PAK4 and SSH1

Pathways associated with anti-PAK4 antibody

 Products by Pathway  Pathway Diagram
 Activation Of Rac Pathway antibodies  Activation Of Rac Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 CDC42 Signaling Events Pathway antibodies  CDC42 Signaling Events Pathway Diagram
 ErbB Signaling Pathway antibodies  ErbB Signaling Pathway Diagram
 ErbB Signaling Pathway antibodies  ErbB Signaling Pathway Diagram
 ErbB Signaling Pathway antibodies  ErbB Signaling Pathway Diagram
 FGF Signaling Pathway antibodies  FGF Signaling Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram

Diseases associated with anti-PAK4 antibody

 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >10 publications with PAK4 and Carcinoma
 Adenocarcinoma Antibodies  >6 publications with PAK4 and Adenocarcinoma
 Cell Transformation, Neoplastic Antibodies  >6 publications with PAK4 and Cell Transformation, Neoplastic
 Neoplasm Metastasis Antibodies  >4 publications with PAK4 and Neoplasm Metastasis
 Liver Diseases Antibodies  >4 publications with PAK4 and Liver Diseases
 Carcinoma, Hepatocellular Antibodies  >4 publications with PAK4 and Carcinoma, Hepatocellular
 Liver Neoplasms Antibodies  >4 publications with PAK4 and Liver Neoplasms
 Prostatic Diseases Antibodies  >3 publications with PAK4 and Prostatic Diseases
 Genital Diseases, Male Antibodies  >3 publications with PAK4 and Genital Diseases, Male
 Breast Neoplasms Antibodies  >3 publications with PAK4 and Breast Neoplasms

Organs/Tissues associated with anti-PAK4 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >7 publications with PAK4 and Brain
 Embryonic Tissue Antibodies  >5 publications with PAK4 and Embryonic Tissue
 Vascular Antibodies  >4 publications with PAK4 and Vascular
 Lung Antibodies  >4 publications with PAK4 and Lung
 Liver Antibodies  >4 publications with PAK4 and Liver
 Prostate Antibodies  >4 publications with PAK4 and Prostate
 Kidney Antibodies  >3 publications with PAK4 and Kidney
 Eye Antibodies  >3 publications with PAK4 and Eye
 Nerve Antibodies  >3 publications with PAK4 and Nerve
 Heart Antibodies  >3 publications with PAK4 and Heart
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