• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

Methionine-Trna Synthetase, Mitochondrial (MARS) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS627005

MBS627005 is an antibody targeting MARS. Also known as Methionine-tRNA Synthetase, Mitochondrial, CT (Methionyl-tRNA Synthetase 2, MARS2, Mitochondrial Methionine-tRNA Ligase, MtMetRS, Methionine-tRNA Ligase 2). Reactive in Human. Host: Rabbit. More details

$895 / 0.2 mL +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Methionine-tRNA Synthetase, Mitochondrial (MARS), Polyclonal Antibody
Full Product Name
Methionine-tRNA Synthetase, Mitochondrial, CT (Methionyl-tRNA Synthetase 2, MARS2, Mitochondrial Methionine-tRNA Ligase, MtMetRS, Methionine-tRNA Ligase 2)
Product Gene Name
anti-MARS antibody
Product Synonym Names
Anti -Methionine-tRNA Synthetase, Mitochondrial, CT (Methionyl-tRNA Synthetase 2, MARS2, Mitochondrial Methionine-tRNA Ligase, MtMetRS, Methionine-tRNA Ligase 2)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, 0.09% sodium azide.
Purity/Purification
Purified
Purified by ammonium sulfate precipitation.
Specificity
Recognizes human MARS2.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
101,116 Da
Chromosome Location
Chromosome: 12; NC_000012.11 (57881736..57910438). Location: 12q13
OMIM
156560
3D Structure
ModBase 3D Structure for P56192
Immunogen
Synthetic peptide selected from the C-terminal region of human MARS2 (KLH).

Product Categories/Family for anti-MARS antibody

Antibodies; Abs to Enzymes; Synthetase
Applications Tested/Suitable for anti-MARS antibody
ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-MARS antibody
Suitable for use in ELISA, Western Blot, and Immunohistochemistry.
Dilution: ELISA: 1:1,000
Western Blot: 1:50-1:100
Immunohistochemistry: 1:10-1:50

Western Blot (WB) of anti-MARS antibody

Western blot analysis of anti-MARS2 Antibody (C-term) (AP7841b) in mouse testis tissue lysates (35ug/lane). MARS2(arrow) was detected using the purified Pab.
Rabbit Anti-MARS Polyclonal Antibody – Cat# MBS627005

Immunohistochemistry (IHC) of anti-MARS antibody

Formalin-fixed and paraffin-embedded human colon carcinoma tissue reacted with MARS2 antibody (C-term) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Rabbit Anti-MARS Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS627005

Other Notes

Small volumes of anti-MARS antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for MARS. It may not necessarily be applicable to this product.

NCBI GI #
30583515
NCBI GeneID
4141
NCBI Accession #
AAP36002.1
UniProt Primary Accession #
P56192
UniProt Secondary Accession #
Q14895; Q53H14; Q96A15; Q96BZ0; Q9NSE0
UniProt Related Accession #
P56192
NCBI Official Full Name
methionine-tRNA synthetase
NCBI Official Synonym Full Names
methionyl-tRNA synthetase
NCBI Official Symbol
MARS
NCBI Official Synonym Symbols
MRS; METRS; MTRNS
UniProt Protein Name
Methionine--tRNA ligase, cytoplasmic
UniProt Synonym Protein Names
Methionyl-tRNA synthetase
Protein Family
Guanylate kinase-associated protein
UniProt Gene Name
MARS
UniProt Synonym Gene Names
MetRS
UniProt Entry Name
SYMC_HUMAN
NCBI Protein Information
methionine--tRNA ligase, cytoplasmic; cytosolic methionyl-tRNA synthetase; methionine tRNA ligase 1, cytoplasmic

NCBI Summary for MARS

This gene encodes a member of the class I family of aminoacyl-tRNA synthetases. These enzymes play a critical role in protein biosynthesis by charging tRNAs with their cognate amino acids. The encoded protein is a component of the multi-tRNA synthetase complex and catalyzes the ligation of methionine to tRNA molecules. [provided by RefSeq, Jan 2011]
Show more

UniProt Comments for MARS

MARS: a member of the class I family of aminoacyl-tRNA synthetases. These enzymes play a critical role in protein biosynthesis by charging tRNAs with their cognate amino acids. The encoded protein is a component of the multi-tRNA synthetase complex and catalyzes the ligation of methionine to tRNA molecules. [provided by RefSeq, Jan 2011]

Protein type: Translation; Ligase; Other Amino Acids Metabolism - selenoamino acid; EC 6.1.1.10

Chromosomal Location of Human Ortholog: 12q13.3

Cellular Component: membrane; mitochondrion; cytoplasm; cytosol

Molecular Function: methionine-tRNA ligase activity; ATP binding; tRNA binding

Biological Process: tRNA aminoacylation for protein translation; methionyl-tRNA aminoacylation; gene expression

Disease: Infantile Liver Failure Syndrome 2; Charcot-marie-tooth Disease, Axonal, Type 2u
Show more

Research Articles on MARS

1. Data show that aminoacyl-tRNA synthetase-interacting multifunctional protein-3 (AIMP3)/p18 is released from aminoacyl-tRNA synthetase-interacting multifunctional protein-3 (AIMP3) by UV irradiation-induced stress.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-MARS antibody

 Reference Product  PubMed Publications
 LARS antibody  >7 publications with MARS and LARS
 RARS antibody  >1 publications with MARS and RARS
 IARS antibody  >1 publications with MARS and IARS

Pathways associated with anti-MARS antibody

 Products by Pathway  Pathway Diagram
 Aminoacyl-tRNA Biosynthesis Pathway antibodies  Aminoacyl-tRNA Biosynthesis Pathway Diagram
 Aminoacyl-tRNA Biosynthesis Pathway antibodies  Aminoacyl-tRNA Biosynthesis Pathway Diagram
 Aminoacyl-tRNA Biosynthesis, Eukaryotes Pathway antibodies  Aminoacyl-tRNA Biosynthesis, Eukaryotes Pathway Diagram
 Aminoacyl-tRNA Biosynthesis, Eukaryotes Pathway antibodies  Aminoacyl-tRNA Biosynthesis, Eukaryotes Pathway Diagram
 Cytosolic TRNA Aminoacylation Pathway antibodies  Cytosolic TRNA Aminoacylation Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Selenocompound Metabolism Pathway antibodies  Selenocompound Metabolism Pathway Diagram
 Selenocompound Metabolism Pathway antibodies  Selenocompound Metabolism Pathway Diagram
 TRNA Aminoacylation Pathway antibodies  TRNA Aminoacylation Pathway Diagram

Diseases associated with anti-MARS antibody

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >1105 publications with MARS and Nervous System Diseases
 Cardiovascular Diseases Antibodies  >965 publications with MARS and Cardiovascular Diseases
 Neoplasms Antibodies  >936 publications with MARS and Neoplasms
 Liver Diseases Antibodies  >656 publications with MARS and Liver Diseases
 Brain Diseases Antibodies  >452 publications with MARS and Brain Diseases
 Hematologic Diseases Antibodies  >433 publications with MARS and Hematologic Diseases
 Anemia Antibodies  >301 publications with MARS and Anemia
 Kidney Diseases Antibodies  >263 publications with MARS and Kidney Diseases
 Pain Antibodies  >201 publications with MARS and Pain
 Anemia, Hemolytic Antibodies  >180 publications with MARS and Anemia, Hemolytic

Organs/Tissues associated with anti-MARS antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >1222 publications with MARS and Blood
 Liver Antibodies  >703 publications with MARS and Liver
 Bone Antibodies  >438 publications with MARS and Bone
 Heart Antibodies  >365 publications with MARS and Heart
 Brain Antibodies  >354 publications with MARS and Brain
 Vascular Antibodies  >290 publications with MARS and Vascular
 Lung Antibodies  >268 publications with MARS and Lung
 Skin Antibodies  >250 publications with MARS and Skin
 Kidney Antibodies  >250 publications with MARS and Kidney
 Muscle Antibodies  >186 publications with MARS and Muscle
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000