Rabbit Anti-ACOT8 Polyclonal Antibody – Cat# MBS6270987

ACOT8 Antibody – Rabbit Polyclonal

Name: ACOT8 Antibody; Polyclonal; Rabbit; Human/Mouse-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS6270987
Price: 1060 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6270987

Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. It may mediate… More details

$1060 / 0.1 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

ACOT8, Polyclonal Antibody

Full Product Name

ACOT8, CT (ACOT8, ACTEIII, PTE1, PTE2, Acyl-coenzyme A thioesterase 8, Acyl-CoA thioesterase 8, Choloyl-coenzyme A thioesterase, HIV-Nef-associated acyl-CoA thioesterase, PTE-2, Peroxisomal acyl-coenzyme A thioester hydrolase 1, Peroxisomal long-chain acy

Product Gene Name

anti-ACOT8 antibody

Product Synonym Names

ACOT8; ACTEIII; PTE1; PTE2; Acyl-coenzyme A thioesterase 8; Acyl-CoA thioesterase 8; Choloyl-coenzyme A thioesterase; HIV-Nef-associated acyl-CoA thioesterase; PTE-2; Peroxisomal acyl-coenzyme A thioester hydrolase 1; Peroxisomal long-chain acyl-CoA thioesterase 1; Thioesterase II

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human, Mouse

Form/Format

Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight550.

Purity/Purification

Purified by Protein A Affinity Chromatography.

Preparation and Storage

Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight550 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Molecular Weight

35,914 Da

Chromosome Location

Chromosome: 20; NC_000020.10 (44470360..44486048, complement). Location: 20q13.12

OMIM

608123

3D Structure

ModBase 3D Structure for O14734

Immunogen

ACOT8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 290~319 amino acids from the C-terminal region of human ACOT8.

Conjugate

MaxLight550

Note

Preservative Free

Product Categories/Family for anti-ACOT8 antibody

Antibodies; Coenzyme A

Applications Tested/Suitable for anti-ACOT8 antibody

Flow Cytometry (FC/FACS), FLISA, Immunohistochemistry (IHC), Western Blot (WB)

Application Notes for anti-ACOT8 antibody

FC/FACS: 1:10-50
FLISA: 1:1,000
IHC: 1:50-100
WB: 1:100-500
Applications are based on unconjugated antibody.

Product References and Citations for anti-ACOT8 antibody

Choudhary C., et.al., Science 325:834-840(2009). Daub H., et.al., Mol. Cell 31:438-448(2008).

Other Notes

Small volumes of anti-ACOT8 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ACOT8 purchase

MBS6270987 is an antibody targeting ACOT8. Also known as ACOT8, CT (ACOT8, ACTEIII, PTE1, PTE2, Acyl-coenzyme A thioesterase 8, Acyl-CoA thioesterase 8, Choloyl-coenzyme A thioesterase, HIV-Nef-associated acyl-CoA thioesterase, PTE-2, Peroxisomal acyl-coenzyme A thioester hydrolase 1, Peroxisomal long-chain acy. Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for ACOT8. It may not necessarily be applicable to this product.

NCBI GI #

34577075

NCBI GeneID

10005

NCBI Accession #

NP_005460.2

UniProt Primary Accession #

O14734

UniProt Secondary Accession #

O15261; Q17RX4

UniProt Related Accession #

O14734

GenBank Nucleotide #

NM_005469.3

NCBI Official Full Name

acyl-coenzyme A thioesterase 8

NCBI Official Synonym Full Names

acyl-CoA thioesterase 8

NCBI Official Symbol

ACOT8

NCBI Official Synonym Symbols

hTE; PTE1; PTE2; PTE-1; PTE-2; HNAACTE; hACTE-III

UniProt Protein Name

Acyl-coenzyme A thioesterase 8

UniProt Synonym Protein Names

Choloyl-coenzyme A thioesterase; HIV-Nef-associated acyl-CoA thioesterase; PTE-2; Peroxisomal acyl-coenzyme A thioester hydrolase 1; PTE-1; Peroxisomal long-chain acyl-CoA thioesterase 1; Thioesterase II

Protein Family

Acyl-coenzyme A thioesterase

UniProt Gene Name

ACOT8

UniProt Synonym Gene Names

ACTEIII; PTE1; PTE2; Acyl-CoA thioesterase 8; PTE-1; hACTE-III; hACTEIII; hTE

UniProt Entry Name

ACOT8_HUMAN

NCBI Protein Information

acyl-coenzyme A thioesterase 8; thioesterase II; thioesterase III; choloyl-CoA hydrolase; palmitoyl-CoA hydrolase; choloyl-coenzyme A thioesterase; long-chain fatty-acyl-CoA hydrolase; peroxisomal acyl-CoA thioesterase 1; HIV-Nef associated acyl-CoA thioe

NCBI Summary for ACOT8

The protein encoded by this gene is a peroxisomal thioesterase that appears to be involved more in the oxidation of fatty acids rather than in their formation. The encoded protein can bind to the human immunodeficiency virus-1 protein Nef, and mediate Nef-induced down-regulation of CD4 in T-cells. [provided by RefSeq, Oct 2010]

UniProt Comments for ACOT8

ACOT8: Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. May mediate Nef-induced down-regulation of CD4. Major thioesterase in peroxisomes. Competes with BAAT (Bile acid CoA: amino acid N- acyltransferase) for bile acid-CoA substrate (such as chenodeoxycholoyl-CoA). Shows a preference for medium-length fatty acyl-CoAs. May be involved in the metabolic regulation of peroxisome proliferation. Belongs to the C/M/P thioester hydrolase family.

Protein type: EC 3.1.2.27; Hydrolase

Chromosomal Location of Human Ortholog: 20q13.12

Cellular Component: peroxisomal matrix; mitochondrion

Molecular Function: protein binding; acyl-CoA hydrolase activity; choloyl-CoA hydrolase activity; palmitoyl-CoA hydrolase activity; receptor binding

Biological Process: peroxisome fission; bile acid biosynthetic process; fatty acid beta-oxidation using acyl-CoA oxidase; acyl-CoA metabolic process; viral reproduction; bile acid metabolic process; unsaturated fatty acid metabolic process; cellular lipid metabolic process; dicarboxylic acid catabolic process

Research Articles on ACOT8

1. An isoform of long-chain acyl-CoA hydrolase may be responsible for the nafamostat hydrolysis in human liver cytosol.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-ACOT8 antibody

Products by Pathway	Pathway Diagram
Beta-oxidation Of Pristanoyl-CoA Pathway antibodies	Beta-oxidation Of Pristanoyl-CoA Pathway Diagram
Beta-oxidation Of Very Long Chain Fatty Acids Pathway antibodies	Beta-oxidation Of Very Long Chain Fatty Acids Pathway Diagram
Bile Acid And Bile Salt Metabolism Pathway antibodies	Bile Acid And Bile Salt Metabolism Pathway Diagram
Bile Acid Biosynthesis, Cholesterol => Cholate Pathway antibodies	Bile Acid Biosynthesis, Cholesterol => Cholate Pathway Diagram
Bile Acid Biosynthesis, Cholesterol => Cholate Pathway antibodies	Bile Acid Biosynthesis, Cholesterol => Cholate Pathway Diagram
Metabolism Pathway antibodies	Metabolism Pathway Diagram
Metabolism Of Lipids And Lipoproteins Pathway antibodies	Metabolism Of Lipids And Lipoproteins Pathway Diagram
Peroxisomal Lipid Metabolism Pathway antibodies	Peroxisomal Lipid Metabolism Pathway Diagram
Peroxisome Pathway antibodies	Peroxisome Pathway Diagram
Peroxisome Pathway antibodies	Peroxisome Pathway Diagram

Diseases associated with anti-ACOT8 antibody

Disease Name	Pubmed Publications
Death Antibodies	>2 publications with ACOT8 and Death
Fatty Liver Antibodies	>1 publications with ACOT8 and Fatty Liver

Organs/Tissues associated with anti-ACOT8 antibody

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>2 publications with ACOT8 and Blood
Lymph Antibodies	>1 publications with ACOT8 and Lymph
Kidney Antibodies	>1 publications with ACOT8 and Kidney
Liver Antibodies	>1 publications with ACOT8 and Liver
Lung Antibodies	>1 publications with ACOT8 and Lung
Lymph Node Antibodies	>1 publications with ACOT8 and Lymph Node