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ADCY10 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6271675

MBS6271675 is an antibody targeting ADCY10. Also known as ADCY10, ID (ADCY10, SAC, Adenylate cyclase type 10, AH-related protein, Adenylate cyclase homolog, Germ cell soluble adenylyl cyclase, Testicular soluble adenylyl cyclase) (Biotin). Reactive in Human.… More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
ADCY10, Polyclonal Antibody
Full Product Name
ADCY10, ID (ADCY10, SAC, Adenylate cyclase type 10, AH-related protein, Adenylate cyclase homolog, Germ cell soluble adenylyl cyclase, Testicular soluble adenylyl cyclase) (Biotin)
Product Gene Name
anti-ADCY10 antibody
Product Synonym Names
ADCY10; SAC; Adenylate cyclase type 10; AH-related protein; Adenylate cyclase homolog; Germ cell soluble adenylyl cyclase; Testicular soluble adenylyl cyclase
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Biotin.
Purity/Purification
Purified by Protein A Affinity Chromatography.
Preparation and Storage
Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
169,750 Da
OMIM
143870
3D Structure
ModBase 3D Structure for Q96PN6
Immunogen
ADCY10 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 564-591 amino acids from the Central region of human ADCY10.
Conjugate
Biotin
Note
Preservative Free

Product Categories/Family for anti-ADCY10 antibody

Antibodies; Enzymes; Cyclase
Applications Tested/Suitable for anti-ADCY10 antibody
Flow Cytometry (FC/FACS), ELISA (EIA), Western Blot (WB)
Application Notes for anti-ADCY10 antibody
FC/FACS: 1:10-50
ELISA: 1:1,000
WB: 1:100-500
Applications are based on unconjugated antibody.

Western Blot (WB) of anti-ADCY10 antibody

ADCY10 Antibody (Center) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the ADCY10 antibody detected the ADCY10 protein (arrow).
Rabbit Anti-ADCY10 Polyclonal Antibody – Cat# MBS6271675

Flow Cytometry (FC/FACS) of anti-ADCY10 antibody

ADCY10 Antibody (Center) flow cytometric analysis of K562 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Rabbit Anti-ADCY10 Polyclonal Antibody, Flow Cytometry (FC/FACS) – Cat# MBS6271675

Other Notes

Small volumes of anti-ADCY10 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for ADCY10. It may not necessarily be applicable to this product.

NCBI GI #
268370055
NCBI GeneID
55811
NCBI Accession #
NP_001161221.1
NCBI Related Accession #
NP_060887.2
UniProt Primary Accession #
Q96PN6
UniProt Secondary Accession #
O95558; Q5R329; Q5R330; Q8WXV4; Q9NNX0; B4DZF0; F5GWS5
UniProt Related Accession #
Q96PN6
GenBank Nucleotide #
NM_001167749.2
NCBI Official Full Name
adenylate cyclase type 10 isoform 2
NCBI Official Synonym Full Names
adenylate cyclase 10
NCBI Official Symbol
ADCY10
NCBI Official Synonym Symbols
SAC; HCA2; SACI; Sacy; hsAC; HEL-S-7a
UniProt Protein Name
Adenylate cyclase type 10
UniProt Synonym Protein Names
AH-related protein; Adenylate cyclase homolog; Germ cell soluble adenylyl cyclase; hsAC; sAC; Testicular soluble adenylyl cyclase
Protein Family
Adenylate cyclase
UniProt Gene Name
ADCY10
UniProt Synonym Gene Names
SAC; hsAC; sAC
UniProt Entry Name
ADCYA_HUMAN
NCBI Protein Information
adenylate cyclase type 10

NCBI Summary for ADCY10

The protein encoded by this gene belongs to a distinct class of adenylyl cyclases that is soluble and insensitive to G protein or forskolin regulation. Activity of this protein is regulated by bicarbonate. Variation at this gene has been observed in patients with absorptive hypercalciuria. Alternatively spliced transcript variants encoding different isoforms have been observed. There is a pseudogene of this gene on chromosome 6. [provided by RefSeq, Jul 2014]
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UniProt Comments for ADCY10

SAC: Soluble adenylyl cyclase that has a critical role in mammalian spermatogenesis. Produces the cAMP which mediates in part the cAMP-responsive nuclear factors indispensable for maturation of sperm in the epididymis. Induces capacitation, the maturational process that sperm undergo prior to fertilization. May be the bicarbonate sensor. Involved in ciliary beat regulation. Genetic variations in ADCY10 are a cause of susceptibility to hypercalciuria absorptive type 2 (HCA2). Absorptive hypercalciuria is a common type of hypercalciuria, a condition characterized by excessive urinary calcium excretion. Absorptive hypercalciuria is due to gastrointestinal hyperabsorption of calcium and is a frequent cause of calcium oxalate nephrolithiasis. Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Adenylyl cyclase; Nucleotide Metabolism - purine; Lyase; EC 4.6.1.1

Chromosomal Location of Human Ortholog: 1q24

Cellular Component: growth cone; cytoskeleton; cell soma; perinuclear region of cytoplasm; apical part of cell; axon; dendrite; cytoplasm; plasma membrane; cytosol

Molecular Function: manganese ion binding; magnesium ion binding; ATPase binding; ATP binding; adenylate cyclase activity

Biological Process: positive regulation of apoptosis; cAMP biosynthetic process; spermatogenesis

Disease: Hypercalciuria, Absorptive, 2
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Research Articles on ADCY10

1. results thus provide 1) novel insights into the communication between allosteric regulatory and active sites, 2) a novel mechanism for sAC inhibition, and 3) pharmacological compounds targeting this allosteric site and utilizing this mode of inhibition.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-ADCY10 antibody

 Reference Product  PubMed Publications
 PDE4B antibody  >1 publications with ADCY10 and PDE4B
 PDE7A antibody  >1 publications with ADCY10 and PDE7A
 PDE4A antibody  >1 publications with ADCY10 and PDE4A

Pathways associated with anti-ADCY10 antibody

 Products by Pathway  Pathway Diagram
 Circadian Entrainment Pathway antibodies  Circadian Entrainment Pathway Diagram
 Circadian Entrainment Pathway antibodies  Circadian Entrainment Pathway Diagram
 Endothelin Pathway antibodies  Endothelin Pathway Diagram
 Hedgehog 'off' State Pathway antibodies  Hedgehog 'off' State Pathway Diagram
 Purine Metabolism Pathway antibodies  Purine Metabolism Pathway Diagram
 Purine Metabolism Pathway antibodies  Purine Metabolism Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By Hedgehog Pathway antibodies  Signaling By Hedgehog Pathway Diagram
 CAMP Signaling Pathway antibodies  CAMP Signaling Pathway Diagram
 CAMP Signaling Pathway antibodies  CAMP Signaling Pathway Diagram

Diseases associated with anti-ADCY10 antibody

 Disease Name  Pubmed Publications
 Male Urogenital Diseases Antibodies  >5 publications with ADCY10 and Male Urogenital Diseases
 Hypertrophy Antibodies  >1 publications with ADCY10 and Hypertrophy

Organs/Tissues associated with anti-ADCY10 antibody

 Organ/Tissue Name  Pubmed Publications
 Testis Antibodies  >5 publications with ADCY10 and Testis
 Eye Antibodies  >3 publications with ADCY10 and Eye
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