Rabbit Anti-AGAP3 Polyclonal Antibody – Cat# MBS6272155

AGAP3 Antibody – Rabbit Polyclonal

Name: AGAP3 Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS6272155
Price: 1025 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6272155

GTPase-activating protein for the ADP ribosylation factor family (Potential). GTPase which may be involved in the degradation of expanded polyglutamine proteins through the ubiquitin-proteasome pathway. More details

$1025 / 0.1 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

AGAP3, Polyclonal Antibody

Full Product Name

AGAP3, NT (AGAP3, CENTG3, Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3, CRAM-associated GTPase, Centaurin-gamma-3, MR1-interacting protein) (MaxLight 750)

Product Gene Name

anti-AGAP3 antibody

Product Synonym Names

AGAP3; CENTG3; Arf-GAP with GTPase; ANK repeat and PH domain-containing protein 3; CRAM-associated GTPase; Centaurin-gamma-3; MR1-interacting protein

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human

Form/Format

Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight750.

Purity/Purification

Purified by Protein A Affinity Chromatography.

Preparation and Storage

Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight750 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Molecular Weight

42,517 Da

3D Structure

ModBase 3D Structure for Q96P47

Immunogen

AGAP3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 189-217 amino acids from the N-terminal region of human AGAP3.

Conjugate

MaxLight750

Note

Preservative Free

Product Categories/Family for anti-AGAP3 antibody

Antibodies; GTPase; Rab; Ras; Rho Proteins

Applications Tested/Suitable for anti-AGAP3 antibody

Western Blot (WB), FLISA

Application Notes for anti-AGAP3 antibody

WB: 1:100-500
FLISA: 1:1,000
Applications are based on unconjugated antibody.

Product References and Citations for anti-AGAP3 antibody

Beausoleil, S.A., et al. Nat. Biotechnol. 24(10):1285-1292(2006). Qin, Q., et al. J. Cell Biol. 172(4):497-504(2006). Meurer, S., et al. J. Biol. Chem. 279(47):49346-49354(2004). Surks, H.K., et al. J. Biol. Chem. 278(51):51484-51493(2003). Xia, C., et al. Mol. Cell. Biol. 23(7):2476-2488(2003).

Other Notes

Small volumes of anti-AGAP3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for AGAP3 purchase

MBS6272155 is an antibody targeting AGAP3. Also known as AGAP3, NT (AGAP3, CENTG3, Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3, CRAM-associated GTPase, Centaurin-gamma-3, MR1-interacting protein) (MaxLight 750). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for AGAP3. It may not necessarily be applicable to this product.

NCBI GI #

110227617

NCBI GeneID

116988

NCBI Accession #

NP_001036000.1

NCBI Related Accession #

NP_114152.3

UniProt Primary Accession #

Q96P47

UniProt Secondary Accession #

Q59EN0; Q96RK3; B3KNZ8; E9PAL8

UniProt Related Accession #

Q96P47

GenBank Nucleotide #

NM_001042535.3

NCBI Official Full Name

arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 isoform b

NCBI Official Synonym Full Names

ArfGAP with GTPase domain, ankyrin repeat and PH domain 3

NCBI Official Symbol

AGAP3

NCBI Official Synonym Symbols

CRAG; AGAP-3; CENTG3; MRIP-1; cnt-g3

UniProt Protein Name

Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3

UniProt Synonym Protein Names

CRAM-associated GTPase; CRAG; Centaurin-gamma-3; Cnt-g3; MR1-interacting protein; MRIP-1

Protein Family

Arf-GAP with GTPase, ANK repeat and PH domain-containing protein

UniProt Gene Name

AGAP3

UniProt Synonym Gene Names

CENTG3; AGAP-3; CRAG; Cnt-g3; MRIP-1

UniProt Entry Name

AGAP3_HUMAN

NCBI Protein Information

arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3

NCBI Summary for AGAP3

This gene encodes an essential component of the N-methyl-D-aspartate (NMDA) receptor signaling complex which mediates long-term potentiation in synapses by linking activation of NMDA receptor to alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor trafficking. The encoded protein contains an N-terminal GTPase-like domain, a pleckstrin homology domain, an ArfGAP domain and several C-terminal ankryn repeat domains. [provided by RefSeq, Apr 2017]

UniProt Comments for AGAP3

CENTG3: a member of the centaurin family of ADP-ribosylation factor directed (ARF) GTPase-activating proteins (GAPs). Protective against the pathogenesis of polyglutamine diseases. Mediates the nuclear translocation of the CENTG3-polyQ complexes and the formation of promyelocytic leukemia (PML) protein-associated nuclear bodies in reactive oxygen species (ROS) signaling. Promotes the degradation of polyQ proteins at PML nuclear bodies through the ubiquitin-proteasome pathway. Knockdown by small interfering RNA in neuronal cells consistently blocked the nuclear translocation of polyQ and enhanced polyQ-mediated cell death. Three alternatively-spliced isoforms have been described.

Protein type: GAPs; GAPs, ARF

Chromosomal Location of Human Ortholog: 7q36.1

Cellular Component: membrane; cytoplasm; nucleus

Molecular Function: GTPase activity; GTP binding; zinc ion binding; polyubiquitin binding

Biological Process: proteasomal ubiquitin-dependent protein catabolic process; protein import into nucleus, translocation; small GTPase mediated signal transduction; positive regulation of GTPase activity

Research Articles on AGAP3

1. AGAP3 is an essential signaling component of the NMDA receptor complex that links NMDA receptor activation to AMPA receptor trafficking.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-AGAP3 antibody

Reference Product	PubMed Publications
FOS antibody	>1 publications with AGAP3 and FOS

Pathways associated with anti-AGAP3 antibody

Products by Pathway	Pathway Diagram
Endocytosis Pathway antibodies	Endocytosis Pathway Diagram
Endocytosis Pathway antibodies	Endocytosis Pathway Diagram

Diseases associated with anti-AGAP3 antibody

Disease Name	Pubmed Publications
Nervous System Diseases Antibodies	>1 publications with AGAP3 and Nervous System Diseases

Organs/Tissues associated with anti-AGAP3 antibody

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>2 publications with AGAP3 and Brain