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ALDH1A3 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6272740

Aldehyde dehydrogenase isozymes are thought to play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. The enzyme ALDH1A3 uses retinal as a substrate, either in a free or cellular retinol-binding protein… More details

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Product Overview

Online Datasheet in PDF
Product Name
ALDH1A3, Polyclonal Antibody
Full Product Name
ALDH1A3, ID (ALDH1A3, ALDH6, Aldehyde dehydrogenase family 1 member A3, Aldehyde dehydrogenase 6, Retinaldehyde dehydrogenase 3) (AP)
Product Gene Name
anti-ALDH1A3 antibody
Product Synonym Names
ALDH1A3; ALDH6; Aldehyde dehydrogenase family 1 member A3; Aldehyde dehydrogenase 6; Retinaldehyde dehydrogenase 3
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Alkaline Phosphatase.
Purity/Purification
Purified by saturated ammonium sulfate precipitation followed by dialysis against PBS.
Specificity
Recognizes human ALDH1A3. Species Crossreactivity: mouse
Preparation and Storage
Store product at 4 degree C. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight
512
OMIM
gene 615113
3D Structure
ModBase 3D Structure for P47895
Immunogen
ALDH1A3 antibody is generated from rabbits immunized with a KLH conjugated Synthetic peptide selected from the center region of human ALDH1A3.
Conjugate
AP
Note
Preservative Free

Product Categories/Family for anti-ALDH1A3 antibody

Antibodies; Enzymes; Dehydrogenase
Applications Tested/Suitable for anti-ALDH1A3 antibody
Immunohistochemistry (IHC), ELISA (EIA), Western Blot (WB)
Application Notes for anti-ALDH1A3 antibody
IHC: 1:10-50
ELISA: 1:1,000
WB: 1:50-100
Applications are based on unconjugated antibody.

Western Blot (WB) of anti-ALDH1A3 antibody

Western blot analysis of anti-ALDH1A3 Antibody (Center) pre-incubated with and without blocking peptide in Jurkat cell line lysate. ALDH1A3 (arrow) was detected using the purified Pab.
Rabbit Anti-ALDH1A3 Polyclonal Antibody – Cat# MBS6272740

Western Blot (WB) of anti-ALDH1A3 antibody

Western blot analysis of ALDH1A3 Antibody (Center) in mouse spleen tissue lysates (35ug/lane). ALDH1A3 (arrow) was detected using the purified Pab.
Rabbit Anti-ALDH1A3 Polyclonal Antibody, Western Blot (WB) – Cat# MBS6272740

Immunohistochemistry (IHC) of anti-ALDH1A3 antibody

Formalin-fixed and paraffin-embedded human kidney tissue reacted with ALDH1A3 Antibody (Center), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Rabbit Anti-ALDH1A3 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS6272740

Product References and Citations for anti-ALDH1A3 antibody

Rexer, B.N., Cancer Res. 61 (19), 7065-7070 (2001). Yoshida, A., Eur. J. Biochem. 251 (3), 549-557 (1998).

Other Notes

Small volumes of anti-ALDH1A3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ALDH1A3 purchase

MBS6272740 is an antibody targeting ALDH1A3. Also known as ALDH1A3, ID (ALDH1A3, ALDH6, Aldehyde dehydrogenase family 1 member A3, Aldehyde dehydrogenase 6, Retinaldehyde dehydrogenase 3) (AP). Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for ALDH1A3. It may not necessarily be applicable to this product.

NCBI GI #
52788258
NCBI GeneID
220
NCBI Accession #
P47895.2
UniProt Primary Accession #
P47895
UniProt Secondary Accession #
Q6NT64
UniProt Related Accession #
P47895
NCBI Official Full Name
Aldehyde dehydrogenase family 1 member A3
NCBI Official Synonym Full Names
aldehyde dehydrogenase 1 family, member A3
NCBI Official Symbol
ALDH1A3
NCBI Official Synonym Symbols
ALDH6; MCOP8; RALDH3; ALDH1A6
UniProt Protein Name
Aldehyde dehydrogenase family 1 member A3
UniProt Synonym Protein Names
Aldehyde dehydrogenase 6; Retinaldehyde dehydrogenase 3; RALDH-3; RalDH3
Protein Family
Aldehyde dehydrogenase family
UniProt Gene Name
ALDH1A3
UniProt Synonym Gene Names
ALDH6; RALDH-3; RalDH3
UniProt Entry Name
AL1A3_HUMAN
NCBI Protein Information
aldehyde dehydrogenase family 1 member A3; aldehyde dehydrogenase 6; acetaldehyde dehydrogenase 6; retinaldehyde dehydrogenase 3

NCBI Summary for ALDH1A3

This gene encodes an aldehyde dehydrogenase enzyme that uses retinal as a substrate. Mutations in this gene have been associated with microphthalmia, isolated 8, and expression changes have also been detected in tumor cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]
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UniProt Comments for ALDH1A3

ALDH1A3: Recognizes as substrates free retinal and cellular retinol-binding protein-bound retinal. Seems to be the key enzyme in the formation of an RA gradient along the dorso-ventral axis during the early eye development and also in the development of the olfactory system. Belongs to the aldehyde dehydrogenase family.

Protein type: Oxidoreductase; Amino Acid Metabolism - histidine; Xenobiotic Metabolism - metabolism by cytochrome P450; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Xenobiotic Metabolism - drug metabolism - cytochrome P450; EC 1.2.1.5; Amino Acid Metabolism - tyrosine; Amino Acid Metabolism - phenylalanine

Chromosomal Location of Human Ortholog: 15q26.3

Cellular Component: cytoplasm; cytosol

Molecular Function: aldehyde dehydrogenase (NAD) activity; protein homodimerization activity; aldehyde dehydrogenase [NAD(P)+] activity; retinal dehydrogenase activity

Biological Process: inner ear morphogenesis; retinal metabolic process; righting reflex; embryonic eye morphogenesis; retinol metabolic process; positive regulation of apoptosis; olfactory pit development; retinoic acid metabolic process; optic cup morphogenesis involved in camera-type eye development; locomotory behavior; neuromuscular process controlling balance; nucleus accumbens development

Disease: Microphthalmia, Isolated 8
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Research Articles on ALDH1A3

1. Nine individuals, from one inbred kindred, segregating isolated A/M with orbital cysts were homozygous for a missense mutation in the gene encoding the A3 isoform of the ALDH1A3.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-ALDH1A3 antibody

 Products by Pathway  Pathway Diagram
 Chemical Carcinogenesis Pathway antibodies  Chemical Carcinogenesis Pathway Diagram
 Chemical Carcinogenesis Pathway antibodies  Chemical Carcinogenesis Pathway Diagram
 Drug Metabolism - Cytochrome P450 Pathway antibodies  Drug Metabolism - Cytochrome P450 Pathway Diagram
 Drug Metabolism - Cytochrome P450 Pathway antibodies  Drug Metabolism - Cytochrome P450 Pathway Diagram
 Glycolysis / Gluconeogenesis Pathway antibodies  Glycolysis / Gluconeogenesis Pathway Diagram
 Glycolysis / Gluconeogenesis Pathway antibodies  Glycolysis / Gluconeogenesis Pathway Diagram
 Histidine Metabolism Pathway antibodies  Histidine Metabolism Pathway Diagram
 Histidine Metabolism Pathway antibodies  Histidine Metabolism Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Of Xenobiotics By Cytochrome P450 Pathway antibodies  Metabolism Of Xenobiotics By Cytochrome P450 Pathway Diagram

Diseases associated with anti-ALDH1A3 antibody

 Disease Name  Pubmed Publications
 Glioblastoma Antibodies  >6 publications with ALDH1A3 and Glioblastoma
 Adenocarcinoma Antibodies  >4 publications with ALDH1A3 and Adenocarcinoma
 Carcinoma Antibodies  >4 publications with ALDH1A3 and Carcinoma
 Neoplasm Metastasis Antibodies  >4 publications with ALDH1A3 and Neoplasm Metastasis
 Lung Diseases Antibodies  >3 publications with ALDH1A3 and Lung Diseases
 Lung Neoplasms Antibodies  >3 publications with ALDH1A3 and Lung Neoplasms
 Breast Neoplasms Antibodies  >3 publications with ALDH1A3 and Breast Neoplasms
 Disease Models, Animal Antibodies  >3 publications with ALDH1A3 and Disease Models, Animal
 Inflammation Antibodies  >3 publications with ALDH1A3 and Inflammation
 Carcinoma, Squamous Cell Antibodies  >2 publications with ALDH1A3 and Carcinoma, Squamous Cell

Organs/Tissues associated with anti-ALDH1A3 antibody

 Organ/Tissue Name  Pubmed Publications
 Eye Antibodies  >17 publications with ALDH1A3 and Eye
 Lung Antibodies  >8 publications with ALDH1A3 and Lung
 Liver Antibodies  >6 publications with ALDH1A3 and Liver
 Skin Antibodies  >6 publications with ALDH1A3 and Skin
 Brain Antibodies  >6 publications with ALDH1A3 and Brain
 Mammary Gland Antibodies  >3 publications with ALDH1A3 and Mammary Gland
 Embryonic Tissue Antibodies  >3 publications with ALDH1A3 and Embryonic Tissue
 Adipose Tissue Antibodies  >3 publications with ALDH1A3 and Adipose Tissue
 Thyroid Antibodies  >3 publications with ALDH1A3 and Thyroid
 Connective Tissue Antibodies  >3 publications with ALDH1A3 and Connective Tissue
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