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AMELX Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6273202

This gene encodes a member of the amelogenin family of extracellular matrix proteins. Amelogenins are involved in biomineralization during tooth enamel development. Mutations in this gene cause X-linked amelogenesis imperfecta. Alternative splicing results in… More details

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Product Overview

Online Datasheet in PDF
Product Name
AMELX, Polyclonal Antibody
Full Product Name
AMELX, NT (AMELX, AMG, AMGX, Amelogenin, X isoform) (AP)
Product Gene Name
anti-AMELX antibody
Product Synonym Names
AMELX; AMG; AMGX; Amelogenin; X isoform
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Alkaline Phosphatase (AP).
Purity/Purification
Purified by Protein A Affinity Chromatography.
Preparation and Storage
Store product at 4 degree C. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight
21,603 Da
Chromosome Location
Chromosome: X; NC_000023.10 (11311533..11318881). Location: Xp22.31-p22.1
OMIM
300391
3D Structure
ModBase 3D Structure for Q99217
Immunogen
AMELX antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 16-46 amino acids from the N-terminal region of human AMELX.
Conjugate
AP
Note
Preservative Free

Product Categories/Family for anti-AMELX antibody

Antibodies; Proteins
Applications Tested/Suitable for anti-AMELX antibody
Immunohistochemistry (IHC), ELISA (EIA), Western Blot (WB)
Application Notes for anti-AMELX antibody
IHC: 1:10-50
ELISA: 1:1,000
WB: 1:100-500
Applications are based on unconjugated antibody.

Western Blot (WB) of anti-AMELX antibody

AMELX Antibody (N-term) western blot analysis in K562 cell line lysates (35ug/lane).This demonstrates the AMELX antibody detected the AMELX protein (arrow).
Rabbit Anti-AMELX Polyclonal Antibody – Cat# MBS6273202

Immunohistochemistry (IHC) of anti-AMELX antibody

AMELX Antibody (N-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human stomach tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of AMELX Antibody (N-term) for immunohistochemistry. Clinical relevance has not been evaluated.
Rabbit Anti-AMELX Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS6273202

Flow Cytometry (FC/FACS) of anti-AMELX antibody

AMELX Antibody (N-term) flow cytometric analysis of K562 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated donkey-anti-rabbit secondary antibodies were used for the analysis.
Rabbit Anti-AMELX Polyclonal Antibody, Flow Cytometry (FC/FACS) – Cat# MBS6273202

Product References and Citations for anti-AMELX antibody

Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010). Almqvist, S., et al. J Mater Sci Mater Med 21(3):947-954(2010). Lee, S.K., et al. J. Dent. Res. 89(1):46-50(2010). Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009). Tomas, C., et al. Forensic Sci Int Genet 3(1):1-6(2008).

Other Notes

Small volumes of anti-AMELX antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for AMELX purchase

MBS6273202 is an antibody targeting AMELX. Also known as AMELX, NT (AMELX, AMG, AMGX, Amelogenin, X isoform) (AP). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for AMELX. It may not necessarily be applicable to this product.

NCBI GI #
33356556
NCBI GeneID
265
NCBI Accession #
NP_872621.1
NCBI Related Accession #
NP_001133.1
UniProt Primary Accession #
Q99217
UniProt Secondary Accession #
Q96NW6; Q9UCA7
UniProt Related Accession #
Q99217
GenBank Nucleotide #
NM_182680.1
NCBI Official Full Name
amelogenin, X isoform isoform 3
NCBI Official Synonym Full Names
amelogenin, X-linked
NCBI Official Symbol
AMELX
NCBI Official Synonym Symbols
AMG; AI1E; AIH1; ALGN; AMGL; AMGX
UniProt Protein Name
Amelogenin, X isoform
Protein Family
Amelogenin
UniProt Gene Name
AMELX
UniProt Synonym Gene Names
AMG; AMGX
UniProt Entry Name
AMELX_HUMAN
NCBI Protein Information
amelogenin, X isoform; amelogenesis imperfecta 1; amelogenin (amelogenesis imperfecta 1, X-linked); amelogenin (X chromosome, amelogenesis imperfecta 1)

UniProt Comments for AMELX

AMELX: Plays a role in biomineralization. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel. Defects in AMELX are the cause of amelogenesis imperfecta type 1E (AI1E). A X-linked defect of dental enamel formation. Teeth have only a thin layer of enamel with normal hardness. The thinness of the enamel makes the teeth appear small. Belongs to the amelogenin family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: Xp22.31-p22.1

Cellular Component: proteinaceous extracellular matrix; cell surface

Molecular Function: identical protein binding; protein binding; growth factor activity; hydroxyapatite binding; structural constituent of tooth enamel

Biological Process: osteoblast differentiation; cell proliferation; ion homeostasis; biomineral formation; positive regulation of collagen biosynthetic process; chondrocyte differentiation; epithelial to mesenchymal transition; signal transduction; cell adhesion; odontogenesis of dentine-containing teeth

Disease: Amelogenesis Imperfecta, Type Ie
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-AMELX antibody

 Reference Product  PubMed Publications
 MMP20 antibody  >28 publications with AMELX and MMP20
 ENAM antibody  >28 publications with AMELX and ENAM
 BGN antibody  >4 publications with AMELX and BGN
 TUFT1 antibody  >3 publications with AMELX and TUFT1
 DMP1 antibody  >3 publications with AMELX and DMP1
 AMTN antibody  >2 publications with AMELX and AMTN
 LAMP1 antibody  >2 publications with AMELX and LAMP1
 KRT5 antibody  >1 publications with AMELX and KRT5

Diseases associated with anti-AMELX antibody

 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >2 publications with AMELX and Carcinoma
 Weight Loss Antibodies  >2 publications with AMELX and Weight Loss
 Amelogenesis imperfecta, hypoplastic/hypomaturation, X-linked 1 Antibodies  >2 publications with AMELX and Amelogenesis imperfecta, hypoplastic/hypomaturation, X-linked 1
 Lung Diseases Antibodies  >1 publications with AMELX and Lung Diseases
 Hemorrhage Antibodies  >1 publications with AMELX and Hemorrhage
 Brain Diseases Antibodies  >1 publications with AMELX and Brain Diseases
 Necrosis Antibodies  >1 publications with AMELX and Necrosis
 Inflammation Antibodies  >1 publications with AMELX and Inflammation
 Hyperplasia Antibodies  >1 publications with AMELX and Hyperplasia

Organs/Tissues associated with anti-AMELX antibody

 Organ/Tissue Name  Pubmed Publications
 Connective Tissue Antibodies  >5 publications with AMELX and Connective Tissue
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