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ATL3 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6276316

ATL3 is GTPase tethering membranes through formation of trans-homooligomer and mediating homotypic fusion of endoplasmic reticulum membranes. ATL3 is function in endoplasmic reticulum tubular network biogenesis. More details

$1060 / 0.2 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
ATL3, Polyclonal Antibody
Full Product Name
ATL3, ID (ATL3, Atlastin-3) (APC)
Product Gene Name
anti-ATL3 antibody
Product Synonym Names
ATL3; Atlastin-3
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Hamster, Mouse
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Allophycocyanin (APC).
Purity/Purification
Purified by Protein A Affinity Chromatography.
Preparation and Storage
Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: APC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight
60,542 Da
Chromosome Location
Chromosome: 11; NC_000011.9 (63396437..63439083, complement). Location: 11q13.1
OMIM
609369
3D Structure
ModBase 3D Structure for Q6DD88
Immunogen
ATL3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between amino acids 230-260 from the Central region of human ATL3.
Conjugate
APC
Note
Preservative Free
Special Handling
Light sensitive

Product Categories/Family for anti-ATL3 antibody

Antibodies; Proteins
Applications Tested/Suitable for anti-ATL3 antibody
Western Blot (WB), FLISA
Application Notes for anti-ATL3 antibody
WB: 1:100-500
FLISA: 1:1,000
Applications are based on unconjugated antibody.

Western Blot (WB) of anti-ATL3 antibody

Western blot analysis of ATL3 Antibody (Center) in mouse liver tissue lysates (35ug/lane). ATL3 (arrow) was detected using the purified Pab.
Rabbit Anti-ATL3 Polyclonal Antibody – Cat# MBS6276316

Western Blot (WB) of anti-ATL3 antibody

Western blot analysis of ATL3 Antibody (Center) in CHO cell line lysates (35ug/lane). ATL3 (arrow) was detected using the purified Pab.
Rabbit Anti-ATL3 Polyclonal Antibody, Western Blot (WB) – Cat# MBS6276316

Product References and Citations for anti-ATL3 antibody

Hu, J., et al. Cell 138(3):549-561(2009). Rismanchi, N., et al. Hum. Mol. Genet. 17(11):1591-1604(2008).

Other Notes

Small volumes of anti-ATL3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ATL3 purchase

MBS6276316 is an antibody targeting ATL3. Also known as ATL3, ID (ATL3, Atlastin-3) (APC). Reactive in Human, Hamster, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for ATL3. It may not necessarily be applicable to this product.

NCBI GI #
45827806
NCBI GeneID
25923
NCBI Accession #
NP_056274.3
UniProt Primary Accession #
Q6DD88
UniProt Secondary Accession #
Q8N7W5; Q9H8Q5; Q9UFL1
UniProt Related Accession #
Q6DD88
GenBank Nucleotide #
NM_015459.3
NCBI Official Full Name
atlastin-3
NCBI Official Synonym Full Names
atlastin GTPase 3
NCBI Official Symbol
ATL3
NCBI Official Synonym Symbols
DKFZp564J0863
UniProt Protein Name
Atlastin-3
Protein Family
Atlastin
UniProt Gene Name
ATL3
UniProt Entry Name
ATLA3_HUMAN
NCBI Protein Information
atlastin-3; atlastin 3; OTTHUMP00000237071; OTTHUMP00000237072

NCBI Summary for ATL3

This gene encodes a member of a family of dynamin-like, integral membrane GTPases. The encoded protein is required for the proper formation of the network of interconnected tubules of the endoplasmic reticulum. Mutations in this gene may be associated with hereditary sensory neuropathy type IF. Alternatively spliced transcript variants that encode distinct isoforms have been described. [provided by RefSeq, Feb 2014]
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UniProt Comments for ATL3

ATL3: GTPase tethering membranes through formation of trans- homooligomer and mediating homotypic fusion of endoplasmic reticulum membranes. Functions in endoplasmic reticulum tubular network biogenesis. Belongs to the GBP family. Atlastin subfamily.

Protein type: Membrane protein, multi-pass; EC 3.6.5.-; Membrane protein, integral

Chromosomal Location of Human Ortholog: 11q13.1

Cellular Component: endoplasmic reticulum membrane; membrane; endoplasmic reticulum; integral to membrane

Molecular Function: GTPase activity; identical protein binding; GTP binding

Biological Process: endoplasmic reticulum organization and biogenesis; ER to Golgi vesicle-mediated transport; metabolic process; Golgi organization and biogenesis; protein homooligomerization

Disease: Neuropathy, Hereditary Sensory, Type If
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Research Articles on ATL3

1. A family of human GTPases, atlastin-2 and -3 that are closely related to atlastin-1 are described.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with anti-ATL3 antibody

 Disease Name  Pubmed Publications
 Hypertension Antibodies  >1 publications with ATL3 and Hypertension
 Lung Diseases Antibodies  >1 publications with ATL3 and Lung Diseases

Organs/Tissues associated with anti-ATL3 antibody

 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >1 publications with ATL3 and Muscle
 Vascular Antibodies  >1 publications with ATL3 and Vascular
 Brain Antibodies  >1 publications with ATL3 and Brain
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