AURKB Antibody – Rabbit Polyclonal

AurB: a member of the AUR family of kinases. May be directly involved in regulating the cleavage of polar spindle microtubules and is a key regulator for the onset of cytokinesis during mitosis. Expressed during S and G2/M phase and expression is upregulated in cancer cells during M phase. Localized to the midzone of central spindle in late anaphase and concentrated into the midbody in telophase and cytokinesis. Colocalizes with gamma tubulin in the mid-body. Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Overexpressed in colorectal and other cancer cell lines and thought to cause aneuploidy via histone phosphorylation.

Protein type: Kinase, protein; EC 2.7.11.1; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Other group; AUR family

Cellular Component: spindle pole centrosome; chromosome; kinetochore; cytoskeleton; spindle microtubule; cytoplasm; spindle; midbody; spindle midzone; nucleus; chromosome, pericentric region; condensed nuclear chromosome, pericentric region; chromocenter

Molecular Function: transferase activity; protein serine/threonine kinase activity; protein binding; metal ion binding; transferase activity, transferring phosphorus-containing groups; nucleotide binding; protein serine/threonine/tyrosine kinase activity; histone serine kinase activity; kinase activity; ATP binding; protein kinase activity

Biological Process: positive regulation of cytokinesis; spindle stabilization; mitosis; spindle checkpoint; spindle midzone assembly involved in mitosis; negative regulation of transcription from RNA polymerase II promoter; cell cycle; regulation of cytokinesis; protein amino acid phosphorylation; mitotic spindle organization and biogenesis; cell division; negative regulation of protein binding; phosphorylation; negative regulation of B cell apoptosis