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Neurocan (NCAN) Antibody – Sheep Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS627691

Neurocan (Neural proteoglycan; also CSPG3) is a secreted, 300-350kD proteoglycan member of the lectican family of molecules. It is expressed by neurons and astrocytes, and has multiple binding partners, including heparin, FGF2, HB-CAM, glypican-1, syndecan-3,… More details

$1155 / 0.05 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Neurocan (NCAN), Polyclonal Antibody
Full Product Name
Neurocan (Neurocan Core Protein, Chondroitin Sulfate Proteoglycan 3, Ncan, Cspg3) (Biotin)
Product Gene Name
anti-NCAN antibody
Product Synonym Names
Anti -Neurocan (Neurocan Core Protein, Chondroitin Sulfate Proteoglycan 3, Ncan, Cspg3) (Biotin)
Clonality
Polyclonal
Isotype
IgG
Host
Sheep
Species Reactivity
Mouse, Rat
Form/Format
Supplied as a lyophilized powder from PBS, 50ug/1ug BSA. Labeled with Biotin. Reconstitute with sterile TBS, pH 7.3, 20mM Trizma, 150mM sodium chloride, 0.1% BSA.
Purity/Purification
Affinity Purified
Purified by immunoaffinity chromatography.
Specificity
Recognizes mouse Neurocan, Species Crossreactivity: rat.
Preparation and Storage
Lyophilized powder may be stored at -20 degree C. Stable for 12 months at -20 degree C. Reconstitute with sterile TBS, 0.1% BSA. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Reconstituted product is stable for 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight
143,093 Da
Chromosome Location
Chromosome: 19; NC_000019.9 (19322773..19363061). Location: 19p12
OMIM
600826
3D Structure
ModBase 3D Structure for O14594
Immunogen
Purified, CHO cell-derived, recombinant mouse Neurocan (aa23-637; Accession # NP_031815).

Product Categories/Family for anti-NCAN antibody

Antibodies; Abs to Proteins
Applications Tested/Suitable for anti-NCAN antibody
Western Blot (WB)
Application Notes for anti-NCAN antibody
Suitable for use in Western Blot.
Dilution: Western Blot: 0.1-0.2ug/ml

Other Notes

Small volumes of anti-NCAN antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for NCAN purchase

MBS627691 is an antibody targeting NCAN. Also known as Neurocan (Neurocan Core Protein, Chondroitin Sulfate Proteoglycan 3, Ncan, Cspg3) (Biotin). Reactive in Mouse, Rat. Host: Sheep.

Additional Details

NCBI/Uniprot data below describe general gene information for NCAN. It may not necessarily be applicable to this product.

NCBI GI #
118600983
NCBI GeneID
1463
NCBI Accession #
NP_004377.2
UniProt Primary Accession #
O14594
UniProt Secondary Accession #
Q9UPK6
UniProt Related Accession #
O14594
GenBank Nucleotide #
NM_004386.2
NCBI Official Full Name
neurocan core protein
NCBI Official Synonym Full Names
neurocan
NCBI Official Symbol
NCAN
NCBI Official Synonym Symbols
CSPG3
UniProt Protein Name
Neurocan core protein
UniProt Synonym Protein Names
Chondroitin sulfate proteoglycan 3
Protein Family
Neurocan core protein
UniProt Gene Name
NCAN
UniProt Synonym Gene Names
CSPG3; NEUR
UniProt Entry Name
NCAN_HUMAN
NCBI Protein Information
neurocan core protein; neurocan proteoglycan; chondroitin sulfate proteoglycan 3 (neurocan)

NCBI Summary for NCAN

Neurocan is a chondroitin sulfate proteoglycan thought to be involved in the modulation of cell adhesion and migration.[supplied by OMIM, Jul 2002]

UniProt Comments for NCAN

CSPG3: May modulate neuronal adhesion and neurite growth during development by binding to neural cell adhesion molecules (NG-CAM and N-CAM). Chondroitin sulfate proteoglycan; binds to hyaluronic acid. Belongs to the aggrecan/versican proteoglycan family.

Protein type: Secreted, signal peptide; Cell adhesion; Secreted

Chromosomal Location of Human Ortholog: 19p12

Cellular Component: proteinaceous extracellular matrix; lysosomal lumen; Golgi lumen; extracellular region

Molecular Function: extracellular matrix structural constituent; hyaluronic acid binding; calcium ion binding; carbohydrate binding

Biological Process: chondroitin sulfate metabolic process; axon guidance; extracellular matrix organization and biogenesis; chondroitin sulfate biosynthetic process; central nervous system development; glycosaminoglycan metabolic process; carbohydrate metabolic process; chondroitin sulfate catabolic process; regulation of synapse structural plasticity; pathogenesis; cell adhesion; skeletal development; dermatan sulfate biosynthetic process
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Research Articles on NCAN

1. no genetic association between risk allele A for NCAN locus rs1064395 and schizophrenia.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-NCAN antibody

 Reference Product  PubMed Publications
 NCAM1 antibody  >18 publications with NCAN and NCAM1
 L1CAM antibody  >10 publications with NCAN and L1CAM
 CSPG5 antibody  >3 publications with NCAN and CSPG5
 SDC3 antibody  >2 publications with NCAN and SDC3
 DCN antibody  >1 publications with NCAN and DCN

Pathways associated with anti-NCAN antibody

 Products by Pathway  Pathway Diagram
 A Tetrasaccharide Linker Sequence Is Required For GAG Synthesis Pathway antibodies  A Tetrasaccharide Linker Sequence Is Required For GAG Synthesis Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 CS/DS Degradation Pathway antibodies  CS/DS Degradation Pathway Diagram
 Chondroitin Sulfate Biosynthesis Pathway antibodies  Chondroitin Sulfate Biosynthesis Pathway Diagram
 Chondroitin Sulfate/dermatan Sulfate Metabolism Pathway antibodies  Chondroitin Sulfate/dermatan Sulfate Metabolism Pathway Diagram
 Dermatan Sulfate Biosynthesis Pathway antibodies  Dermatan Sulfate Biosynthesis Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 ECM Proteoglycans Pathway antibodies  ECM Proteoglycans Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram

Diseases associated with anti-NCAN antibody

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >33 publications with NCAN and Nervous System Diseases
 Mood Disorders Antibodies  >6 publications with NCAN and Mood Disorders
 Seizures Antibodies  >3 publications with NCAN and Seizures
 Liver Diseases Antibodies  >2 publications with NCAN and Liver Diseases
 Depressive Disorder Antibodies  >1 publications with NCAN and Depressive Disorder
 Nervous System Malformations Antibodies  >1 publications with NCAN and Nervous System Malformations
 Weight Loss Antibodies  >1 publications with NCAN and Weight Loss
 Learning Disorders Antibodies  >1 publications with NCAN and Learning Disorders
 Prenatal Exposure Delayed Effects Antibodies  >1 publications with NCAN and Prenatal Exposure Delayed Effects

Organs/Tissues associated with anti-NCAN antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >90 publications with NCAN and Brain
 Embryonic Tissue Antibodies  >33 publications with NCAN and Embryonic Tissue
 Muscle Antibodies  >5 publications with NCAN and Muscle
 Vascular Antibodies  >4 publications with NCAN and Vascular
 Mixed Antibodies  >1 publications with NCAN and Mixed
 Mammary Gland Antibodies  >1 publications with NCAN and Mammary Gland
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