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AXIN2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6277019

The Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of… More details

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Product Overview

Online Datasheet in PDF
Product Name
AXIN2, Polyclonal Antibody
Full Product Name
AXIN2, CT (AXIN2, Axin-2, Axin-like protein, Axis inhibition protein 2, Conductin) (AP)
Product Gene Name
anti-AXIN2 antibody
Product Synonym Names
AXIN2; Axin-2; Axin-like protein; Axis inhibition protein 2; Conductin
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Alkaline Phosphatase (AP).
Purity/Purification
Purified by Protein A Affinity Chromatography.
Specificity
Recognizes human AXIN2.
Preparation and Storage
Store product at 4 degree C. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight
93,558 Da
Chromosome Location
Chromosome: 17; NC_000017.10 (63524681..63557740, complement). Location: 17q23-q24
OMIM
114500
3D Structure
ModBase 3D Structure for Q9Y2T1
Immunogen
KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 816-843 in the C-terminal region of human AXIN2, UniProt Accession #Q9Y2T1. Species sequence homology: mouse, rat
Conjugate
AP
Note
Preservative Free

Product Categories/Family for anti-AXIN2 antibody

Antibodies; Wnt Proteins
Applications Tested/Suitable for anti-AXIN2 antibody
Immunohistochemistry (IHC), ELISA (EIA), Western Blot (WB)
Application Notes for anti-AXIN2 antibody
IHC: 1:50-100
ELISA: 1:1,000
WB: 1:100-500
Applications are based on unconjugated antibody.

Western Blot (WB) of anti-AXIN2 antibody

Western blot analysis in Jurkat cell line lysates (35ug/lane) usingMBS6007616. This demonstrates the AXIN2 antibody detected the AXIN2 protein (arrow).
Rabbit Anti-AXIN2 Polyclonal Antibody – Cat# MBS6277019

Immunohistochemistry (IHC) of anti-AXIN2 antibody

Immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue using MBS6007616 followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of MBS6007616 for immunohistochemistry.
Rabbit Anti-AXIN2 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS6277019

Flow Cytometry (FC/FACS) of anti-AXIN2 antibody

Flow cytometric analysis of Jurkat cells (right histogram) using MBS6007616 compared to a negative control cell (left histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Rabbit Anti-AXIN2 Polyclonal Antibody, Flow Cytometry (FC/FACS) – Cat# MBS6277019

Product References and Citations for anti-AXIN2 antibody

1. Inkster, B., et al. Neuroimage (2010). In press, 2. Guey, L.T., et al. Eur. Urol. 57(2):283-292(2010), 3. Couch, F.J., et al. Cancer Epidemiol. Biomarkers Prev. 19(1):251-257(2010), 4. Hosgood, H.D. III, et al. Respir Med 103(12):1866-1870 (2009), 5. Olschwang, S., et al. J Oncol 2009, 306786 (2009), 5. Dong, X., et al. Cytogenet. Cell Genet. 93 (1-2),:26-28 (2001), 7. Liu, W., et al. Nat. Genet. 26(2):146-147(2000), 8. von Kries, J.P., et al. Nat. Struct. Biol. 7(9):800-807(2000), 9. Kikuchi, A. Cytokine Growth Factor Rev. 10 (3-4):255-265 (1999), 10. Mai, M., et al. Genomics 55(3):341-344(1999).

Other Notes

Small volumes of anti-AXIN2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for AXIN2 purchase

MBS6277019 is an antibody targeting AXIN2. Also known as AXIN2, CT (AXIN2, Axin-2, Axin-like protein, Axis inhibition protein 2, Conductin) (AP). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for AXIN2. It may not necessarily be applicable to this product.

NCBI GI #
195927059
NCBI GeneID
8313
NCBI Accession #
NP_004646.3
UniProt Primary Accession #
Q9Y2T1
UniProt Secondary Accession #
Q3MJ88; Q9H3M6; Q9UH84
UniProt Related Accession #
Q9Y2T1
GenBank Nucleotide #
NM_004655.3
NCBI Official Full Name
axin-2
NCBI Official Synonym Full Names
axin 2
NCBI Official Symbol
AXIN2
NCBI Official Synonym Symbols
AXIL; ODCRCS
UniProt Protein Name
Axin-2
UniProt Synonym Protein Names
Axin-like protein; Axil; Axis inhibition protein 2; Conductin
Protein Family
Axin
UniProt Gene Name
AXIN2
UniProt Synonym Gene Names
Axil
UniProt Entry Name
AXIN2_HUMAN
NCBI Protein Information
axin-2; conductin; axin-like protein; axis inhibition protein 2

UniProt Comments for AXIN2

axin 2: is a negative regulator of the Wnt pathway, which is critical in stem cell signaling, morphogenesis, the mesenchymal-epithelial transition, and many cancers. Axin functions as a tumor suppressor. Probably facilitates the phosphorylation of beta-catenin and APC by GSK3B, leading to their ubiquitination and subsequent proteolysis. Is downregulated during progression of esophageal squamous cell carcinoma. Axin1/2 mediate cross-talk between TGF-beta and Wnt signaling pathways.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 17q24.1

Cellular Component: microtubule cytoskeleton; nucleoplasm; Golgi apparatus; centrosome; cytoplasmic microtubule; postsynaptic density; cytoplasm; cytoplasmic membrane-bound vesicle; plasma membrane; cell cortex; cytosol; nucleus; beta-catenin destruction complex

Molecular Function: protein binding; enzyme binding; ubiquitin protein ligase binding; beta-catenin binding; protein kinase binding; GTPase activator activity

Biological Process: odontogenesis; negative regulation of cell proliferation; cell proliferation; intramembranous ossification; regulation of mismatch repair; mRNA stabilization; negative regulation of osteoblast differentiation; dorsal/ventral axis specification; positive regulation of protein amino acid phosphorylation; maintenance of DNA repeat elements; bone mineralization; positive regulation of GTPase activity

Disease: Oligodontia-colorectal Cancer Syndrome
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Research Articles on AXIN2

1. Borderline association with a decreased risk of cleft lip with or without cleft palate was observed for the AXIN2 rs3923087 variant.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-AXIN2 antibody

 Reference Product  PubMed Publications
 CTNNB1 antibody  >240 publications with AXIN2 and CTNNB1
 APC antibody  >62 publications with AXIN2 and APC
 WNT3A antibody  >38 publications with AXIN2 and WNT3A
 AXIN1 antibody  >37 publications with AXIN2 and AXIN1
 TCF7L2 antibody  >14 publications with AXIN2 and TCF7L2
 TCF7L1 antibody  >2 publications with AXIN2 and TCF7L1
 GSK3B antibody  >2 publications with AXIN2 and GSK3B
 CSNK1E antibody  >1 publications with AXIN2 and CSNK1E

Pathways associated with anti-AXIN2 antibody

 Products by Pathway  Pathway Diagram
 Basal Cell Carcinoma Pathway antibodies  Basal Cell Carcinoma Pathway Diagram
 Basal Cell Carcinoma Pathway antibodies  Basal Cell Carcinoma Pathway Diagram
 Canonical Wnt Signaling Pathway antibodies  Canonical Wnt Signaling Pathway Diagram
 Colorectal Cancer Pathway antibodies  Colorectal Cancer Pathway Diagram
 Colorectal Cancer Pathway antibodies  Colorectal Cancer Pathway Diagram
 Endometrial Cancer Pathway antibodies  Endometrial Cancer Pathway Diagram
 Endometrial Cancer Pathway antibodies  Endometrial Cancer Pathway Diagram
 Hippo Signaling Pathway antibodies  Hippo Signaling Pathway Diagram
 Hippo Signaling Pathway antibodies  Hippo Signaling Pathway Diagram
 Neural Crest Differentiation Pathway antibodies  Neural Crest Differentiation Pathway Diagram

Diseases associated with anti-AXIN2 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >123 publications with AXIN2 and Neoplasms
 Colorectal Neoplasms Antibodies  >54 publications with AXIN2 and Colorectal Neoplasms
 Colonic Neoplasms Antibodies  >25 publications with AXIN2 and Colonic Neoplasms
 Liver Diseases Antibodies  >14 publications with AXIN2 and Liver Diseases
 Liver Neoplasms Antibodies  >14 publications with AXIN2 and Liver Neoplasms
 Disease Models, Animal Antibodies  >12 publications with AXIN2 and Disease Models, Animal
 Ovarian Neoplasms Antibodies  >8 publications with AXIN2 and Ovarian Neoplasms
 Cardiovascular Diseases Antibodies  >8 publications with AXIN2 and Cardiovascular Diseases
 Carcinoma, Hepatocellular Antibodies  >8 publications with AXIN2 and Carcinoma, Hepatocellular
 Inflammation Antibodies  >7 publications with AXIN2 and Inflammation

Organs/Tissues associated with anti-AXIN2 antibody

 Organ/Tissue Name  Pubmed Publications
 Embryonic Tissue Antibodies  >27 publications with AXIN2 and Embryonic Tissue
 Brain Antibodies  >24 publications with AXIN2 and Brain
 Liver Antibodies  >20 publications with AXIN2 and Liver
 Blood Antibodies  >19 publications with AXIN2 and Blood
 Lung Antibodies  >16 publications with AXIN2 and Lung
 Intestine Antibodies  >15 publications with AXIN2 and Intestine
 Nerve Antibodies  >12 publications with AXIN2 and Nerve
 Eye Antibodies  >10 publications with AXIN2 and Eye
 Kidney Antibodies  >9 publications with AXIN2 and Kidney
 Mammary Gland Antibodies  >9 publications with AXIN2 and Mammary Gland
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