• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

CDC14 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6283667

The protein encoded by this gene is a member of the dual specificity protein tyrosine phosphatase family. This protein is highly similar to Saccharomyces cerevisiae Cdc14, a protein tyrosine phosphatase involved in the exit of cell mitosis and initiation of… More details

$1060 / 0.2 mL +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Cdc14, Polyclonal Antibody
Full Product Name
Cdc14 (CDC14A, Dual specificity protein phosphatase CDC14A, CDC14 cell division cycle 14 homolog A) (Biotin)
Product Gene Name
anti-Cdc14 antibody
Product Synonym Gene Name
CDC14A
Product Synonym Names
CDC14A; Dual specificity protein phosphatase CDC14A; CDC14 cell division cycle 14 homolog A
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Biotin.
Purity/Purification
Purified by Protein G Affinity Chromatography.
Preparation and Storage
Store product at 4 degree C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20 degree C. Aliquots are stable at -20 degree C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
66kDa
OMIM
603504
3D Structure
ModBase 3D Structure for Q9UNH5
Immunogen
Cdc14 antibody is generated from rabbits immunized with a recombinant protein encoding a portion within aa 1~379 of human cdc14.
Conjugate
Biotin
Note
Preservative Free

Product Categories/Family for anti-Cdc14 antibody

Antibodies; Cell Division Cycle (CDC)
Applications Tested/Suitable for anti-Cdc14 antibody
Flow Cytometry (FC/FACS), ELISA (EIA), Immunohistochemistry (IHC), Western Blot (WB)
Application Notes for anti-Cdc14 antibody
FC/FACS: 1:10-50
ELISA: 1:1,000
IHC: 1:10-50
WB: 1:100-500
Applications are based on unconjugated antibody.

Western Blot (WB) of anti-Cdc14 antibody

His6-cdc14 Antibody western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the cdc14 antibody detected the cdc14 protein (arrow).
Rabbit Anti-CDC14 Polyclonal Antibody – Cat# MBS6283667

Immunohistochemistry (IHC) of anti-Cdc14 antibody

Cdc14 Antibody immunohistochemistry analysis in formalin fixed and paraffin embedded human stomach tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of Cdc14 Antibody for immunohistochemistry. Clinical relevance has not been evaluated.
Rabbit Anti-CDC14 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS6283667

Flow Cytometry (FC/FACS) of anti-Cdc14 antibody

Cdc14 Antibody flow cytometric analysis of HepG2 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Rabbit Anti-CDC14 Polyclonal Antibody, Flow Cytometry (FC/FACS) – Cat# MBS6283667

Product References and Citations for anti-Cdc14 antibody

Kaiser, B.K., et al. Mol. Biol. Cell 13 (7), 2289-2300 (2002). Mailand, N., et al. Nat. Cell Biol. 4 (4), 317-322 (2002). Bembenek, J. and Yu, H. J. Biol. Chem. 276 (51), 48237-48242 (2001). Li, L., et al. J. Biol. Chem. 275 (4), 2410-2414 (2000). Wong, A.K., et al. Genomics 59 (2), 248-251 (1999). Li, L., et al. J. Biol. Chem. 272 (47), 29403-29406 (1997).

Other Notes

Small volumes of anti-Cdc14 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Cdc14 purchase

MBS6283667 is an antibody targeting Cdc14. Also known as Cdc14 (CDC14A, Dual specificity protein phosphatase CDC14A, CDC14 cell division cycle 14 homolog A) (Biotin). Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for Cdc14. It may not necessarily be applicable to this product.

NCBI GI #
15451929
NCBI GeneID
8556
NCBI Accession #
NP_003663
UniProt Primary Accession #
Q9UNH5
UniProt Related Accession #
Q9UNH5
GenBank Nucleotide #
NM_003672
NCBI Official Full Name
dual specificity protein phosphatase CDC14A isoform 1
NCBI Official Synonym Full Names
cell division cycle 14A
NCBI Official Symbol
CDC14A
NCBI Official Synonym Symbols
cdc14; DFNB32; DFNB35; hCDC14; DFNB105
UniProt Protein Name
Dual specificity protein phosphatase CDC14A
UniProt Synonym Protein Names
CDC14 cell division cycle 14 homolog A
Protein Family
Cell division control protein
UniProt Gene Name
CDC14A
UniProt Entry Name
CC14A_HUMAN
NCBI Protein Information
dual specificity protein phosphatase CDC14A

NCBI Summary for Cdc14

The protein encoded by this gene is a member of the dual specificity protein tyrosine phosphatase family. It is highly similar to Saccharomyces cerevisiae Cdc14, a protein tyrosine phosphatase involved in the exit of cell mitosis and initiation of DNA replication, suggesting a role in cell cycle control. This protein has been shown to interact with, and dephosphorylate tumor suppressor protein p53, and is thought to regulate the function of p53. Alternative splicing of this gene results in several transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]
Show more

UniProt Comments for Cdc14

CDC14A: Dual-specificity phosphatase. Required for centrosome separation and productive cytokinesis during cell division. May dephosphorylate the APC subunit FZR1/CDH1, thereby promoting APC- FZR1 dependent degradation of mitotic cyclins and subsequent exit from mitosis. Belongs to the protein-tyrosine phosphatase family. Non-receptor class CDC14 subfamily. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; EC 3.1.3.48; Protein phosphatase, dual-specificity; EC 3.1.3.16

Chromosomal Location of Human Ortholog: 1p21

Cellular Component: nucleoplasm; centrosome; cytoplasm; spindle; nucleus

Molecular Function: protein binding; protein tyrosine/serine/threonine phosphatase activity; protein tyrosine phosphatase activity; phosphoprotein phosphatase activity

Biological Process: cell proliferation; cell division; cell cycle
Show more

Research Articles on Cdc14

1. CDC14A activity is necessary for hearing and male fertility.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-Cdc14 antibody

 Reference Product  PubMed Publications
 TP53 antibody  >1 publications with Cdc14 and TP53
 FZR1 antibody  >1 publications with Cdc14 and FZR1

Pathways associated with anti-Cdc14 antibody

 Products by Pathway  Pathway Diagram
 APC/C-mediated Degradation Of Cell Cycle Proteins Pathway antibodies  APC/C-mediated Degradation Of Cell Cycle Proteins Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle, Mitotic Pathway antibodies  Cell Cycle, Mitotic Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Conversion From APC/C:Cdc20 To APC/C:Cdh1 In Late Anaphase Pathway antibodies  Conversion From APC/C:Cdc20 To APC/C:Cdh1 In Late Anaphase Pathway Diagram
 Regulation Of Mitotic Cell Cycle Pathway antibodies  Regulation Of Mitotic Cell Cycle Pathway Diagram

Diseases associated with anti-Cdc14 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >5 publications with Cdc14 and Neoplasms
 Breast Neoplasms Antibodies  >2 publications with Cdc14 and Breast Neoplasms
 Carcinoma Antibodies  >1 publications with Cdc14 and Carcinoma
 Kidney Diseases Antibodies  >1 publications with Cdc14 and Kidney Diseases
 Liver Diseases Antibodies  >1 publications with Cdc14 and Liver Diseases
 Necrosis Antibodies  >1 publications with Cdc14 and Necrosis

Organs/Tissues associated with anti-Cdc14 antibody

 Organ/Tissue Name  Pubmed Publications
 Skin Antibodies  >1 publications with Cdc14 and Skin
 Muscle Antibodies  >1 publications with Cdc14 and Muscle
 Blood Antibodies  >1 publications with Cdc14 and Blood
 Liver Antibodies  >1 publications with Cdc14 and Liver
 Stomach Antibodies  >1 publications with Cdc14 and Stomach
 Embryonic Tissue Antibodies  >1 publications with Cdc14 and Embryonic Tissue
 Brain Antibodies  >1 publications with Cdc14 and Brain
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000