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ABL2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS628704

ABL2 is a cytoplasmic tyrosine kinase which is closely related to but distinct from ABL1. The similarity of the proteins includes the tyrosine kinase domains and extends amino-terminal to include the SH2 and SH3 domains. ABL2 is expressed in both normal and… More details

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Product Overview

Online Datasheet in PDF
Product Name
ABL2, Polyclonal Antibody
Full Product Name
ABL2, ID (Tyrosine-protein Kinase ABL2, Abelson Murine Leukemia Viral Oncogene Homolog 2, Abelson-related Gene Protein, Tyrosine Kinase ARG, ABLL, ARG)
Product Gene Name
anti-Abl2 antibody
Product Synonym Names
Anti -ABL2, ID (Tyrosine-protein Kinase ABL2, Abelson Murine Leukemia Viral Oncogene Homolog 2, Abelson-related Gene Protein, Tyrosine Kinase ARG, ABLL, ARG)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, 0.09% sodium azide.
Purity/Purification
Affinity Purified
Purified by ammonium sulfate precipitation.
Specificity
Recognizes human ABL2.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
128,196 Da
Chromosome Location
Chromosome: 1; NC_000067.5 (158488918..158579750). Location: 1 G3-H1; 1 82.1 cM
3D Structure
ModBase 3D Structure for Q4JIM5
Immunogen
Synthetic peptide selected from the central region of human ABL2 (KLH).

Product Categories/Family for anti-Abl2 antibody

Antibodies; Abs to Tyrosine Kinases
Applications Tested/Suitable for anti-Abl2 antibody
ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-Abl2 antibody
Suitable for use in ELISA, Western Blot, and Immunohistochemistry.
Dilution: ELISA: 1:1,000
Western Blot: 1:100-1:500
Immunohistochemistry: 1:50-1:100

Western Blot (WB) of anti-Abl2 antibody

Western blot analysis of Phospho-ABL-Y412 Antibody Pab in A2058 cell line lysate (35ug/lane). ABL (arrow) was detected using the purified Pab.
Rabbit Anti-ABL2 Polyclonal Antibody – Cat# MBS628704

Dot Blot (DB) of anti-Abl2 antibody

Dot blot analysis of ABL-Y412 Phospho-specific Pab on nitrocellulose membrane. 50ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.5ug per ml.
Rabbit Anti-ABL2 Polyclonal Antibody, Dot Blot (DB) – Cat# MBS628704

Immunohistochemistry (IHC) of anti-Abl2 antibody

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
Rabbit Anti-ABL2 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS628704

Other Notes

Small volumes of anti-Abl2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Abl2 purchase

MBS628704 is an antibody targeting Abl2. Also known as ABL2, ID (Tyrosine-protein Kinase ABL2, Abelson Murine Leukemia Viral Oncogene Homolog 2, Abelson-related Gene Protein, Tyrosine Kinase ARG, ABLL, ARG). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for Abl2. It may not necessarily be applicable to this product.

NCBI GI #
68139002
NCBI GeneID
11352
UniProt Primary Accession #
Q4JIM5
UniProt Related Accession #
Q4JIM5; Q61055; Q99P28
NCBI Official Full Name
ABL2
NCBI Official Synonym Full Names
v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene)
NCBI Official Symbol
Abl2
NCBI Official Synonym Symbols
Arg; Abll; AA536808; MGC169395
UniProt Protein Name
Tyrosine-protein kinase ABL2
UniProt Synonym Protein Names
Abelson murine leukemia viral oncogene homolog 2; Abelson-related gene protein; Tyrosine-protein kinase ARG
Protein Family
Abelson tyrosine-protein kinase
UniProt Gene Name
Abl2
UniProt Synonym Gene Names
Arg
UniProt Entry Name
ABL2_MOUSE
NCBI Protein Information
tyrosine-protein kinase ABL2; tyrosine kinase ARG; tyrosine-protein kinase ARG; Abelson-related gene protein; abelson murine leukemia viral oncogene homolog 2

UniProt Comments for Abl2

Arg: a cytoplasmic tyrosine kinase of the Abl family. Expressed at the highest levels in mature B cells. Promotes catalase degradation in the oxidative stress response. Localizes to dynamic actin structures and may regulate cytoskeleton remodeling during cell differentiation, cell division and cell adhesion. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 2.7.10.2; Protein kinase, TK; Kinase, protein; Oncoprotein; Protein kinase, tyrosine (non-receptor); TK group; Abl family

Cellular Component: extrinsic to internal side of plasma membrane; cytoskeleton; lamellipodium; cell; cytoplasm; cytoplasmic membrane-bound vesicle; dendritic spine; cytosol; phagocytic cup; actin cytoskeleton

Molecular Function: transferase activity; protein binding; metal ion binding; manganese ion binding; protein-tyrosine kinase activity; transferase activity, transferring phosphorus-containing groups; non-membrane spanning protein tyrosine kinase activity; nucleotide binding; magnesium ion binding; kinase activity; ATP binding; protein kinase activity; receptor binding

Biological Process: peptidyl-tyrosine phosphorylation; positive regulation of protein binding; alpha-beta T cell differentiation; cerebellum morphogenesis; platelet-derived growth factor receptor signaling pathway; protein amino acid phosphorylation; regulation of apoptosis; elevation of cytosolic calcium ion concentration; Bergmann glial cell differentiation; visual learning; cell adhesion; neuromuscular process controlling balance; positive regulation of oxidoreductase activity; epidermal growth factor receptor signaling pathway; actin filament bundle formation; cell migration; positive regulation of I-kappaB kinase/NF-kappaB cascade; dendrite morphogenesis; actin filament organization; learning; substrate-bound cell migration, cell extension; phagocytosis; regulation of cell proliferation; negative regulation of Rho protein signal transduction; innate immune response; negative regulation of cell-cell adhesion; actin cytoskeleton organization and biogenesis; phosphorylation; neuron remodeling
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Research Articles on Abl2

1. These data provide evidence that Abl family kinases reduce ganglioside turnover in the plasma membrane by inhibiting host cell sialidase activity.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-Abl2 antibody

 Products by Pathway  Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 ErbB Signaling Pathway antibodies  ErbB Signaling Pathway Diagram
 ErbB Signaling Pathway antibodies  ErbB Signaling Pathway Diagram
 Role Of Abl In Robo-Slit Signaling Pathway antibodies  Role Of Abl In Robo-Slit Signaling Pathway Diagram
 Signaling By Robo Receptor Pathway antibodies  Signaling By Robo Receptor Pathway Diagram
 Viral Myocarditis Pathway antibodies  Viral Myocarditis Pathway Diagram

Organs/Tissues associated with anti-Abl2 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >16 publications with Abl2 and Blood
 Bone Antibodies  >4 publications with Abl2 and Bone
 Lung Antibodies  >2 publications with Abl2 and Lung
 Muscle Antibodies  >2 publications with Abl2 and Muscle
 Liver Antibodies  >2 publications with Abl2 and Liver
 Bone Marrow Antibodies  >2 publications with Abl2 and Bone Marrow
 Thymus Antibodies  >1 publications with Abl2 and Thymus
 Mammary Gland Antibodies  >1 publications with Abl2 and Mammary Gland
 Lymph Node Antibodies  >1 publications with Abl2 and Lymph Node
 Pancreas Antibodies  >1 publications with Abl2 and Pancreas
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