Rabbit Anti-CARD16 Polyclonal Antibody – Cat# MBS628742

Immunocytochemistry of beta-COP in NIH-3T3 cells using MBS628742.

COP, Beta (CARD16) Antibody – Rabbit Polyclonal

Name: CARD16 Antibody; Polyclonal; Rabbit; Mouse/Rat-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS628742
Price: 1010 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS628742

MBS628742 is an antibody targeting CARD16. Also known as COP, beta (Coatomer Protein beta). Reactive in Mouse, Rat. Host: Rabbit. More details

$1010 / 0.1 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

COP, beta (CARD16), Polyclonal Antibody

Full Product Name

COP, beta (Coatomer Protein beta)

Product Gene Name

anti-CARD16 antibody

Product Synonym Names

Anti -COP, beta (Coatomer Protein beta)

Clonality

Polyclonal

Host

Rabbit

Species Reactivity

Mouse, Rat

Form/Format

Liquid. Purified antibody in PBS containing 1mg/ml BSA and 0.05% sodium azide.

Purity/Purification

Purified
Purified

Specificity

Recognizes mouse and rat -COP. Detects a band of~110kDa by Western blot.

Preparation and Storage

-20 degree C

Molecular Weight

22,625 Da

Chromosome Location

Chromosome: 11; NC_000011.9 (104912053..104916051, complement). Location: chromosome: 11

3D Structure

ModBase 3D Structure for Q5EG05

Immunogen

Synthetic peptide corresponding to aa 496-513 (E496AGELKPEEEITVGPVQK513) of rat beta-COP (beta-coat protein).

Product Categories/Family for anti-CARD16 antibody

Antibodies; Abs to Proteins

Applications Tested/Suitable for anti-CARD16 antibody

Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC)

Application Notes for anti-CARD16 antibody

Immunocytochemistry (1:2000), Immunohistochemistry (frozen sections), Western Blot (1:1000)

Other Notes

Small volumes of anti-CARD16 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for CARD16. It may not necessarily be applicable to this product.

NCBI GI #

62953113

NCBI GeneID

114769

NCBI Accession #

NP_001017534.1

UniProt Primary Accession #

Q5EG05

UniProt Secondary Accession #

Q96RJ9

UniProt Related Accession #

Q5EG05

GenBank Nucleotide #

NM_001017534.1

NCBI Official Full Name

caspase recruitment domain-containing protein 16 isoform 1

NCBI Official Synonym Full Names

caspase recruitment domain family, member 16

NCBI Official Symbol

CARD16

NCBI Official Synonym Symbols

COP; COP1; PSEUDO-ICE

UniProt Protein Name

Caspase recruitment domain-containing protein 16

UniProt Synonym Protein Names

CARD only domain-containing protein 1; Caspase-1 inhibitor COP; Pseudo interleukin-1 beta converting enzyme

Protein Family

Caspase recruitment domain-containing protein

UniProt Gene Name

CARD16

UniProt Synonym Gene Names

COP; COP1; Pseudo-ICE

UniProt Entry Name

CAR16_HUMAN

NCBI Protein Information

caspase recruitment domain-containing protein 16; CARD only protein; caspase-1 inhibitor COP; CARD only domain-containing protein 1; pseudo interleukin-1beta converting enzyme; pseudo interleukin-1 beta converting enzyme; caspase-1 dominant-negative inhibitor pseudo-ICE

UniProt Comments for CARD16

CARD16: Caspase inhibitor. Acts as a regulator of procaspase- 1/CASP1 activation implicated in the regulation of the proteolytic maturation of pro-interleukin-1 beta (IL1B) and its release during inflammation. Inhibits the release of IL1B in response to LPS in monocytes. Also induces NF-kappa-B activation during the pro- inflammatory cytokine response. Also able to inhibit CASP1- mediated neuronal cell death, TNF-alpha, hypoxia-, UV-, and staurosporine-mediated cell death but not ER stress-mediated cell death. Acts by preventing activation of caspases CASP1 and CASP4, possibly by preventing the interaction between CASP1 and RIPK2. Down-regulated in patients suffering of Huntington disease. Homooligomer. Interacts with CASP1, CASP4, CARD8 and RIPK2. 2 isoforms of the human protein are produced by alternative splicing

Chromosomal Location of Human Ortholog: 11q22

Molecular Function: cysteine protease inhibitor activity

Biological Process: regulation of apoptosis

Research Articles on CARD16

1. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.