ADRB2 Antibody – Mouse Polyclonal

ADRB2: Beta-adrenergic receptors mediate the catecholamine- induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine. Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB2 sub-subfamily.

Protein type: Membrane protein, multi-pass; Membrane protein, integral; Receptor, GPCR; GPCR, family 1

Cellular Component: intracellular membrane-bound organelle; integral to plasma membrane; dendrite; integral to membrane; dendritic spine; caveola; membrane; axon; apical plasma membrane; cytoplasm; plasma membrane; nucleus; receptor complex; endosome; sarcolemma

Molecular Function: protein homodimerization activity; G-protein alpha-subunit binding; drug binding; norepinephrine binding; epinephrine binding; PDZ domain binding; ionotropic glutamate receptor binding; protein binding; enzyme binding; potassium channel regulator activity; dopamine binding; protein complex binding; beta2-adrenergic receptor activity; B2 bradykinin receptor binding; adenylate cyclase binding

Biological Process: diet induced thermogenesis; wound healing; regulation of vasodilation; positive regulation of apoptosis; positive regulation of potassium ion transport; regulation of systemic arterial blood pressure by norepinephrine-epinephrine; female pregnancy; positive regulation of vasodilation; G-protein signaling, adenylate cyclase activating pathway; positive regulation of MAPKKK cascade; negative regulation of smooth muscle contraction; diaphragm contraction; positive regulation of cell proliferation; negative regulation of ossification; associative learning; bone resorption; aging; regulation of smooth muscle contraction; arrestin mediated desensitization of G-protein coupled receptor protein signaling pathway; synaptic transmission, glutamatergic; receptor-mediated endocytosis; negative regulation of multicellular organism growth; adenylate cyclase activation; response to testosterone stimulus; regulation of sodium ion transport; regulation of calcium ion transport; positive regulation of bone mineralization; liver development; G-protein coupled receptor protein signaling pathway; negative regulation of angiogenesis; positive regulation of the force of heart contraction by epinephrine; response to estrogen stimulus; positive regulation of protein ubiquitination; positive regulation of ATPase activity; heat generation; negative regulation of inflammatory response; response to hypoxia; brown fat cell differentiation; positive regulation of transcription from RNA polymerase II promoter; regulation of sensory perception of pain; response to cold; positive regulation of skeletal muscle growth; regulation of excitatory postsynaptic membrane potential; response to progesterone stimulus; positive regulation of heart contraction; norepinephrine-epinephrine vasodilation involved in regulation of systemic arterial blood pressure