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ALDH1A3 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS629546

Aldehyde dehydrogenase isozymes are thought to play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. The enzyme ALDH1A3 uses retinal as a substrate, either in a free or cellular retinol-binding protein… More details

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Product Overview

Online Datasheet in PDF
Product Name
ALDH1A3, Polyclonal Antibody
Full Product Name
ALDH1A3, NT (Retinaldehyde Dehydrogenase 3, Aldehyde Dehydrogenase 6, Aldehyde Dehydrogenase Family 1 Member A3, ALDH6, RALDH-3, RalDH3)
Product Gene Name
anti-ALDH1A3 antibody
Product Synonym Names
Anti -ALDH1A3, NT (Retinaldehyde Dehydrogenase 3, Aldehyde Dehydrogenase 6, Aldehyde Dehydrogenase Family 1 Member A3, ALDH6, RALDH-3, RalDH3)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
Supplied as a liquid in PBS, 0.09% sodium azide.
Purity/Purification
Purified
Purified by ammonium sulfate precipitation.
Specificity
Recognizes human ALDH1A3. Species Crossreactivity: mouse.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
56,108 Da
Chromosome Location
Chromosome: 15; NC_000015.9 (101420009..101456831). Location: 15q26.3
OMIM
600463
3D Structure
ModBase 3D Structure for P47895
Immunogen
KLH-conjugated synthetic peptide corresponding to a portion of amino acids located within the range aa31-60 in the N-terminal region of human ALDH1A3

Product Categories/Family for anti-ALDH1A3 antibody

Antibodies; Abs to Enzymes; Dehydrogenase
Applications Tested/Suitable for anti-ALDH1A3 antibody
ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-ALDH1A3 antibody
Suitable for use in ELISA, Western Blot, and Immunohistochemistry.
Dilution: ELISA: 1:1,000
Western Blot: 1:50-1:100
Immunohistochemistry: 1:10-1:50

Western Blot (WB) of anti-ALDH1A3 antibody

Western blot analysis of ALDH1A3 in mouse kidney tissue lysates (35ug/lane)
Rabbit Anti-ALDH1A3 Polyclonal Antibody – Cat# MBS629546

Immunohistochemistry (IHC) of anti-ALDH1A3 antibody

Immunohistochemical staining of formalin-fixed and paraffin-embedded human kidney tissue. Detection: Peroxidase-conjugate secondary antibody/DAB staining
Rabbit Anti-ALDH1A3 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS629546

Other Notes

Small volumes of anti-ALDH1A3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ALDH1A3 purchase

MBS629546 is an antibody targeting ALDH1A3. Also known as ALDH1A3, NT (Retinaldehyde Dehydrogenase 3, Aldehyde Dehydrogenase 6, Aldehyde Dehydrogenase Family 1 Member A3, ALDH6, RALDH-3, RalDH3). Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for ALDH1A3. It may not necessarily be applicable to this product.

NCBI GI #
153266822
NCBI GeneID
220
NCBI Accession #
NP_000684.2
UniProt Primary Accession #
P47895
UniProt Secondary Accession #
Q6NT64
UniProt Related Accession #
P47895; Q7Z3A2
GenBank Nucleotide #
NM_000693.2
NCBI Official Full Name
aldehyde dehydrogenase family 1 member A3
NCBI Official Synonym Full Names
aldehyde dehydrogenase 1 family, member A3
NCBI Official Symbol
ALDH1A3
NCBI Official Synonym Symbols
ALDH6; RALDH3; ALDH1A6
UniProt Protein Name
Aldehyde dehydrogenase family 1 member A3
UniProt Synonym Protein Names
Aldehyde dehydrogenase 6; Retinaldehyde dehydrogenase 3
Protein Family
Aldehyde dehydrogenase family
UniProt Gene Name
ALDH1A3
UniProt Synonym Gene Names
ALDH6
UniProt Entry Name
AL1A3_HUMAN
NCBI Protein Information
aldehyde dehydrogenase family 1 member A3; RALDH-3; OTTHUMP00000194835; aldehyde dehydrogenase 6; acetaldehyde dehydrogenase 6; retinaldehyde dehydrogenase 3

NCBI Summary for ALDH1A3

Aldehyde dehydrogenase isozymes are thought to play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. The enzyme encoded by this gene uses retinal as a substrate, either in a free or cellular retinol-binding protein form. [provided by RefSeq]

UniProt Comments for ALDH1A3

ALDH1A3: Recognizes as substrates free retinal and cellular retinol-binding protein-bound retinal. Seems to be the key enzyme in the formation of an RA gradient along the dorso-ventral axis during the early eye development and also in the development of the olfactory system. Belongs to the aldehyde dehydrogenase family.

Protein type: Carbohydrate Metabolism - glycolysis and gluconeogenesis; Xenobiotic Metabolism - metabolism by cytochrome P450; Xenobiotic Metabolism - drug metabolism - cytochrome P450; EC 1.2.1.5; Amino Acid Metabolism - tyrosine; Amino Acid Metabolism - phenylalanine; Oxidoreductase; Amino Acid Metabolism - histidine

Chromosomal Location of Human Ortholog: 15q26.3

Cellular Component: cytoplasm; cytosol

Molecular Function: aldehyde dehydrogenase (NAD) activity; protein homodimerization activity; aldehyde dehydrogenase [NAD(P)+] activity; retinal dehydrogenase activity

Biological Process: inner ear morphogenesis; retinal metabolic process; embryonic eye morphogenesis; retinol metabolic process; positive regulation of apoptosis; righting reflex; olfactory pit development; retinoic acid metabolic process; optic cup morphogenesis involved in camera-type eye development; locomotory behavior; neuromuscular process controlling balance; nucleus accumbens development

Disease: Microphthalmia, Isolated 8
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Research Articles on ALDH1A3

1. ALDH1A3 expression in patient breast tumors correlates significantly with tumor grade, metastasis, and cancer stage

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-ALDH1A3 antibody

 Products by Pathway  Pathway Diagram
 Drug Metabolism - Cytochrome P450 Pathway antibodies  Drug Metabolism - Cytochrome P450 Pathway Diagram
 Drug Metabolism - Cytochrome P450 Pathway antibodies  Drug Metabolism - Cytochrome P450 Pathway Diagram
 Glycolysis / Gluconeogenesis Pathway antibodies  Glycolysis / Gluconeogenesis Pathway Diagram
 Glycolysis / Gluconeogenesis Pathway antibodies  Glycolysis / Gluconeogenesis Pathway Diagram
 Histidine Metabolism Pathway antibodies  Histidine Metabolism Pathway Diagram
 Histidine Metabolism Pathway antibodies  Histidine Metabolism Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Of Xenobiotics By Cytochrome P450 Pathway antibodies  Metabolism Of Xenobiotics By Cytochrome P450 Pathway Diagram
 Metabolism Of Xenobiotics By Cytochrome P450 Pathway antibodies  Metabolism Of Xenobiotics By Cytochrome P450 Pathway Diagram
 Phenylalanine Metabolism Pathway antibodies  Phenylalanine Metabolism Pathway Diagram

Diseases associated with anti-ALDH1A3 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >10 publications with ALDH1A3 and Neoplasms
 Drug Toxicity Antibodies  >3 publications with ALDH1A3 and Drug Toxicity
 Lung Diseases Antibodies  >2 publications with ALDH1A3 and Lung Diseases
 Inflammation Antibodies  >2 publications with ALDH1A3 and Inflammation
 Prostatic Neoplasms Antibodies  >2 publications with ALDH1A3 and Prostatic Neoplasms
 Abnormalities, Drug-Induced Antibodies  >2 publications with ALDH1A3 and Abnormalities, Drug-Induced
 Congenital Abnormalities Antibodies  >2 publications with ALDH1A3 and Congenital Abnormalities
 Adenocarcinoma Antibodies  >1 publications with ALDH1A3 and Adenocarcinoma
 Carcinoma Antibodies  >1 publications with ALDH1A3 and Carcinoma
 Leukemia Antibodies  >1 publications with ALDH1A3 and Leukemia

Organs/Tissues associated with anti-ALDH1A3 antibody

 Organ/Tissue Name  Pubmed Publications
 Eye Antibodies  >7 publications with ALDH1A3 and Eye
 Liver Antibodies  >5 publications with ALDH1A3 and Liver
 Skin Antibodies  >4 publications with ALDH1A3 and Skin
 Lung Antibodies  >2 publications with ALDH1A3 and Lung
 Stomach Antibodies  >2 publications with ALDH1A3 and Stomach
 Bone Antibodies  >2 publications with ALDH1A3 and Bone
 Brain Antibodies  >2 publications with ALDH1A3 and Brain
 Embryonic Tissue Antibodies  >2 publications with ALDH1A3 and Embryonic Tissue
 Mouth Antibodies  >2 publications with ALDH1A3 and Mouth
 Prostate Antibodies  >2 publications with ALDH1A3 and Prostate
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