Rabbit Anti-FKBP6 Polyclonal Antibody – Cat# MBS6299359

FKBP6 Antibody – Rabbit Polyclonal

Name: FKBP6 Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS6299359
Price: 1060 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6299359

The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. The protein may have cis-trans prolyl isomerase activity, and binds… More details

$1060 / 0.1 mL +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

FKBP6, Polyclonal Antibody

Full Product Name

FKBP6, CT (FKBP6, FKBP36, Peptidyl-prolyl cis-trans isomerase FKBP6, 36kD FK506-binding protein, FK506-binding protein 6, Immunophilin FKBP36, Rotamase) (MaxLight 550)

Product Gene Name

anti-FKBP6 antibody

Product Synonym Names

FKBP6; FKBP36; Peptidyl-prolyl cis-trans isomerase FKBP6; 36kD FK506-binding protein; FK506-binding protein 6; Immunophilin FKBP36; Rotamase

Clonality

Polyclonal

Isotype

IgG

Host

Rabbit

Species Reactivity

Human

Form/Format

Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight550.

Purity/Purification

Purified by Protein A Affinity Chromatography.

Preparation and Storage

Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight550 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

OMIM

604839

3D Structure

ModBase 3D Structure for O75344

Immunogen

FKBP6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 255-284 amino acids from the C-terminal region of human FKBP6.

Conjugate

MaxLight550

Note

Preservative Free

Product Categories/Family for anti-FKBP6 antibody

Antibodies; Binding Proteins

Applications Tested/Suitable for anti-FKBP6 antibody

Western Blot (WB), FLISA

Application Notes for anti-FKBP6 antibody

WB: 1:100-500
FLISA: 1:1,000
Applications are based on unconjugated antibody.

Product References and Citations for anti-FKBP6 antibody

Aston, K.I., et al. Hum. Reprod. 25(6):1383-1397(2010). Jarczowski, F., et al. J. Biol. Chem. 284(2):766-773(2009). Jarczowski, F., et al. Biochemistry 47(26):6946-6952(2008). Zhang, W., et al. Reproduction 133(2):511-516(2007). Miyamato, T., et al. Cell. Mol. Biol. Lett. 11(4):557-569(2006).

Other Notes

Small volumes of anti-FKBP6 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for FKBP6 purchase

MBS6299359 is an antibody targeting FKBP6. Also known as FKBP6, CT (FKBP6, FKBP36, Peptidyl-prolyl cis-trans isomerase FKBP6, 36kD FK506-binding protein, FK506-binding protein 6, Immunophilin FKBP36, Rotamase) (MaxLight 550). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for FKBP6. It may not necessarily be applicable to this product.

NCBI GI #

146229346

NCBI GeneID

8468

NCBI Accession #

NP_003593.3

UniProt Primary Accession #

O75344

UniProt Related Accession #

O75344

GenBank Nucleotide #

NP_003593.3

NCBI Official Full Name

inactive peptidyl-prolyl cis-trans isomerase FKBP6 isoform a

NCBI Official Synonym Full Names

FKBP prolyl isomerase 6

NCBI Official Symbol

FKBP6

NCBI Official Synonym Symbols

FKBP36

UniProt Protein Name

Inactive peptidyl-prolyl cis-trans isomerase FKBP6

UniProt Synonym Protein Names

36 kDa FK506-binding protein; 36 kDa FKBP; FKBP-36; FK506-binding protein 6; FKBP-6; Immunophilin FKBP36

Protein Family

FK506-binding protein

UniProt Gene Name

FKBP6

UniProt Synonym Gene Names

FKBP36; Inactive PPIase FKBP6; 36 kDa FKBP; FKBP-36; FKBP-6

UniProt Entry Name

FKBP6_HUMAN

NCBI Protein Information

inactive peptidyl-prolyl cis-trans isomerase FKBP6

NCBI Summary for FKBP6

The protein encoded by this gene is a cis-trans peptidyl-prolyl isomerase that may function in immunoregulation and basic cellular processes involving protein folding and trafficking. This gene is located in a chromosomal region that is deleted in Williams-Beuren syndrome. Defects in this gene may cause male infertility. There are multiple pseudogenes for this gene located nearby on chromosome 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

UniProt Comments for FKBP6

FKBP6: PPIases accelerate the folding of proteins. FKBP6 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region. Haploinsufficiency of FKBP6 may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in the disease. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Isomerase; EC 5.2.1.8

Chromosomal Location of Human Ortholog: 7q11.23

Cellular Component: endoplasmic reticulum membrane; cytoplasm; synaptonemal complex; cytosol

Molecular Function: protein binding; peptidyl-prolyl cis-trans isomerase activity; FK506 binding; Hsp90 protein binding

Biological Process: meiosis; protein peptidyl-prolyl isomerization; protein folding; DNA methylation during gametogenesis; spermatogenesis; RNA-mediated gene silencing; cell differentiation

Research Articles on FKBP6

1. Genome wide DNA methylation assessment approach identified novel biomarkers that differentiate between cervical cancer and normal samples. In the Validation cohort FKBP6 promoter methylation had 73% sensitivity and 80% specificity (AUC = 0.80).

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-FKBP6 antibody

Reference Product	PubMed Publications
GAPDH antibody	>1 publications with FKBP6 and GAPDH

Pathways associated with anti-FKBP6 antibody

Products by Pathway	Pathway Diagram
Cell Cycle Pathway antibodies	Cell Cycle Pathway Diagram
Gene Expression Pathway antibodies	Gene Expression Pathway Diagram
Meiosis Pathway antibodies	Meiosis Pathway Diagram
Meiotic Synapsis Pathway antibodies	Meiotic Synapsis Pathway Diagram
PIWI-interacting RNA (piRNA) Biogenesis Pathway antibodies	PIWI-interacting RNA (piRNA) Biogenesis Pathway Diagram
Regulatory RNA Pathways antibodies	Regulatory RNA Pathways Diagram

Diseases associated with anti-FKBP6 antibody

Disease Name	Pubmed Publications
Infertility, Male Antibodies	>11 publications with FKBP6 and Infertility, Male
Cardiovascular Diseases Antibodies	>9 publications with FKBP6 and Cardiovascular Diseases
Congenital Abnormalities Antibodies	>9 publications with FKBP6 and Congenital Abnormalities
Infertility, Female Antibodies	>2 publications with FKBP6 and Infertility, Female
Myocardial Ischemia Antibodies	>1 publications with FKBP6 and Myocardial Ischemia
Neoplasms, Experimental Antibodies	>1 publications with FKBP6 and Neoplasms, Experimental
Uterine Diseases Antibodies	>1 publications with FKBP6 and Uterine Diseases
Heart Defects, Congenital Antibodies	>1 publications with FKBP6 and Heart Defects, Congenital
Uterine Cervical Neoplasms Antibodies	>1 publications with FKBP6 and Uterine Cervical Neoplasms

Organs/Tissues associated with anti-FKBP6 antibody

Organ/Tissue Name	Pubmed Publications
Testis Antibodies	>10 publications with FKBP6 and Testis
Brain Antibodies	>2 publications with FKBP6 and Brain
Ovary Antibodies	>1 publications with FKBP6 and Ovary
Lung Antibodies	>1 publications with FKBP6 and Lung