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OASL2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS630945

2-prime,5-prime oligoadenylates (2-5As) bind to and activate RNase L, leading to degradation of RNA and inhibition of protein synthesis. 2-5As are produced by 2-5A synthetases (OASs), a highly-conserved family of interferon-induced enzymes. The predicted… More details

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Sample Manual Insert View PDF
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Testing Data View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
OASL (Oasl2), Polyclonal Antibody
Full Product Name
OASL, CT (59kD 2'-5'-oligoadenylate Synthase-like Protein, p59 OASL, p59OASL, Thyroid Receptor-interacting Protein 14, TR-interacting Protein 14, TRIP-14, TRIP14)
Product Gene Name
anti-Oasl2 antibody
Product Synonym Names
Anti -OASL, CT (59kD 2'-5'-oligoadenylate Synthase-like Protein, p59 OASL, p59OASL, Thyroid Receptor-interacting Protein 14, TR-interacting Protein 14, TRIP-14, TRIP14)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, 0.09% sodium azide.
Purity/Purification
Affinity Purified
Purified by Protein G affinity chromatography.
Specificity
Recognizes human OASL.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
58,767 Da
Chromosome Location
Chromosome: 5; NC_000071.6 (114896934..114912245). Location: 5 F; 5
3D Structure
ModBase 3D Structure for Q9Z2F2
Immunogen
Synthetic peptide selected from the C-terminal region of human OASL (KLH).

Product Categories/Family for anti-Oasl2 antibody

Antibodies; Abs to Enzymes; Synthase
Applications Tested/Suitable for anti-Oasl2 antibody
ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC)
Application Notes for anti-Oasl2 antibody
Suitable for use in ELISA, Western Blot, and Immunohistochemistry.
Dilution: ELISA: 1:1,000
Western Blot: 1:100-1:500
Immunohistochemistry: 1:50-1:100

Western Blot (WB) of anti-Oasl2 antibody

The anti-OASL C-term Antibody is used in Western blot to detect OASL in HL60 lysate.
Rabbit Anti-OASL2 Polyclonal Antibody – Cat# MBS630945

Immunohistochemistry (IHC) of anti-Oasl2 antibody

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.
Rabbit Anti-OASL2 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS630945

Other Notes

Small volumes of anti-Oasl2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Oasl2 purchase

MBS630945 is an antibody targeting Oasl2. Also known as OASL, CT (59kD 2'-5'-oligoadenylate Synthase-like Protein, p59 OASL, p59OASL, Thyroid Receptor-interacting Protein 14, TR-interacting Protein 14, TRIP-14, TRIP14). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for Oasl2. It may not necessarily be applicable to this product.

NCBI GI #
21707766
NCBI GeneID
23962
NCBI Accession #
AAH34361.1
UniProt Primary Accession #
Q9Z2F2
UniProt Secondary Accession #
Q9D6S2
UniProt Related Accession #
Q9Z2F2
NCBI Official Full Name
Oasl2 protein
NCBI Official Synonym Full Names
2'-5' oligoadenylate synthetase-like 2
NCBI Official Symbol
Oasl2
NCBI Official Synonym Symbols
Oasl; M1204; Mmu-OASL
UniProt Protein Name
2'-5'-oligoadenylate synthase-like protein 2
UniProt Synonym Protein Names
54 kDa 2'-5'-oligoadenylate synthase-like protein; p54 OASL; M1204
Protein Family
2'-5'-oligoadenylate synthase-like protein
UniProt Gene Name
Oasl2
UniProt Synonym Gene Names
p54 OASL
UniProt Entry Name
OASL2_MOUSE
NCBI Protein Information
2'-5'-oligoadenylate synthase-like protein 2; p54OASL; p54 OASL; 54 kDa 2'-5'-oligoadenylate synthase-like protein 2; 54 kDa 2'-5'-oligoadenylate synthetase-like protein 2

UniProt Comments for Oasl2

Oasl2: Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. Synthesizes oligomers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L. Belongs to the 2-5A synthase family.

Protein type: EC 2.7.7.84

Molecular Function: transferase activity; RNA binding; metal ion binding; double-stranded RNA binding; nucleotide binding; ATP binding; 2'-5'-oligoadenylate synthetase activity; nucleotidyltransferase activity

Biological Process: immune system process; response to virus; innate immune response; immune response; purine nucleotide biosynthetic process; defense response to virus
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-Oasl2 antibody

 Reference Product  PubMed Publications
 Ifit1 antibody  >3 publications with Oasl2 and Ifit1
 Zbp1 antibody  >1 publications with Oasl2 and Zbp1
 Isg15 antibody  >1 publications with Oasl2 and Isg15
 Usp18 antibody  >1 publications with Oasl2 and Usp18
 Irf7 antibody  >1 publications with Oasl2 and Irf7
 Rtp4 antibody  >1 publications with Oasl2 and Rtp4
 Ifi44 antibody  >1 publications with Oasl2 and Ifi44

Pathways associated with anti-Oasl2 antibody

 Products by Pathway  Pathway Diagram
 XPodNet - Protein-protein Interactions In The Podocyte Expanded By STRING Pathway antibodies  XPodNet - Protein-protein Interactions In The Podocyte Expanded By STRING Pathway Diagram
 MRNA Processing Pathway antibodies  MRNA Processing Pathway Diagram

Diseases associated with anti-Oasl2 antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >2 publications with Oasl2 and Inflammation
 Neoplasms Antibodies  >1 publications with Oasl2 and Neoplasms

Organs/Tissues associated with anti-Oasl2 antibody

 Organ/Tissue Name  Pubmed Publications
 Uncharacterized Tissue Antibodies  >1 publications with Oasl2 and Uncharacterized Tissue
 Skin Antibodies  >1 publications with Oasl2 and Skin
 Lymph Node Antibodies  >1 publications with Oasl2 and Lymph Node
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