• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

Estrogen-Related Receptor, Alpha (ESRRA) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS631428

ERR alpha is a nuclear receptor that is closely related to the estrogen receptor. This protein acts as a site specific transcription regulator and has also been shown to interact with estrogen and the transcription factor TFIIB by direct protein-protein… More details

$1010 / 0.1 mg +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Estrogen-Related Receptor, alpha (ESRRA), Polyclonal Antibody
Full Product Name
Estrogen-Related Receptor, alpha (ERRa, NR3B1, NR3 Steroid Receptor)
Product Gene Name
anti-ESRRA antibody
Product Synonym Names
Anti -Estrogen-Related Receptor, alpha (ERRa, NR3B1, NR3 Steroid Receptor)
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
Supplied as a liquid in 0.1M Tris-Glycine, pH 7.4, 150mM sodium chloride, 0.05% sodium azide.
Purity/Purification
Purified
Purified by ammonium sulfate precipitation.
Specificity
Recognizes human ERR-alpha P2. Species Crossreactivity: mouse.
Preparation and Storage
May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Molecular Weight
45,510 Da
Chromosome Location
Chromosome: 11; NC_000011.9 (64072990..64084215). Location: 11q13
OMIM
601998
3D Structure
ModBase 3D Structure for P11474
Immunogen
Linear peptide corresponding to human ERR-alpha (KLH).
Positive Control
HeLa cell lysate

Product Categories/Family for anti-ESRRA antibody

Antibodies; Abs to Receptors; Estrogen
Applications Tested/Suitable for anti-ESRRA antibody
Western Blot (WB), Immunocytochemistry (ICC)
Application Notes for anti-ESRRA antibody
Suitable for use in Western Blot and Immunocytochemistry.
Dilution: Western Blot: 2ug/ml
Immunocytochemistry: 1:500

Immunocytochemistry (ICC) of anti-ESRRA antibody

Immunocytochemistry Analysis: Representative lot data. Confocal fluorescent analysis of HeLa and A431 cells using MBS631428 (Red). Actin filaments have been labeled with AlexaFluor®488 -Phalloidin (Green). Nucleus is stained with DAPI (Blue). This antibody positively stains the nucleus and cytoplasm.
Rabbit Anti-ESRRA Polyclonal Antibody – Cat# MBS631428

Western Blot (WB) of anti-ESRRA antibody

Western Blotting Analysis: Representative lot data. HeLa cell lysate was resolved by electrophoresis, transferred to PVDF membranes and probed with MBS631428 (2ug/mL). Proteins were visualized using a Donkey Anti-Rabbit IgG conjugated to HRP and chemiluminescence detection system. Arrow indicates ERR alpha (~53 kDa).
Rabbit Anti-ESRRA Polyclonal Antibody, Western Blot (WB) – Cat# MBS631428

Other Notes

Small volumes of anti-ESRRA antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ESRRA purchase

MBS631428 is an antibody targeting ESRRA. Also known as Estrogen-Related Receptor, alpha (ERRa, NR3B1, NR3 Steroid Receptor). Reactive in Human, Mouse. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for ESRRA. It may not necessarily be applicable to this product.

NCBI GI #
325495545
NCBI GeneID
2101
NCBI Accession #
ADZ17378.1
UniProt Primary Accession #
P11474
UniProt Secondary Accession #
Q14514
UniProt Related Accession #
P11474
NCBI Official Full Name
estrogen-related nuclear receptor alpha
NCBI Official Synonym Full Names
estrogen-related receptor alpha
NCBI Official Symbol
ESRRA
NCBI Official Synonym Symbols
ERR1; ERRa; ESRL1; NR3B1; ERRalpha
UniProt Protein Name
Steroid hormone receptor ERR1
UniProt Synonym Protein Names
Estrogen receptor-like 1; Estrogen-related receptor alpha; ERR-alpha; Nuclear receptor subfamily 3 group B member 1
Protein Family
Steroid hormone receptor
UniProt Gene Name
ESRRA
UniProt Synonym Gene Names
ERR1; ESRL1; NR3B1; ERR-alpha
UniProt Entry Name
ERR1_HUMAN
NCBI Protein Information
steroid hormone receptor ERR1; ERR-alpha; estrogen receptor-like 1; estrogen-related nuclear receptor alpha; nuclear receptor subfamily 3 group B member 1

NCBI Summary for ESRRA

The protein encoded by this gene is a nuclear receptor that is closely related to the estrogen receptor. This protein acts as a site-specific transcription regulator and has been also shown to interact with estrogen and the transcripton factor TFIIB by direct protein-protein contact. The binding and regulatory activities of this protein have been demonstrated in the regulation of a variety of genes including lactoferrin, osteopontin, medium-chain acyl coenzyme A dehydrogenase (MCAD) and thyroid hormone receptor genes. A processed pseudogene of ESRRA is located on chromosome 13q12.1. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2013]
Show more

UniProt Comments for ESRRA

ERR1: Binds to an ERR-alpha response element (ERRE) containing a single consensus half-site, 5'-TNAAGGTCA-3'. Can bind to the medium-chain acyl coenzyme A dehydrogenase (MCAD) response element NRRE-1 and may act as an important regulator of MCAD promoter. Binds to the C1 region of the lactoferrin gene promoter. Requires dimerization and the coactivator, PGC-1A, for full activity. The ERRalpha/PGC1alpha complex is a regulator of energy metabolism. Belongs to the nuclear hormone receptor family. NR3 subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Nuclear receptor

Chromosomal Location of Human Ortholog: 11q13

Cellular Component: microtubule cytoskeleton; nucleoplasm; intercellular bridge; nucleolus; nucleus

Molecular Function: protein domain specific binding; protein binding; ligand-dependent nuclear receptor activity; DNA binding; zinc ion binding; sequence-specific DNA binding; steroid hormone receptor activity; steroid binding

Biological Process: transcription initiation from RNA polymerase II promoter; mitochondrion organization and biogenesis; intracellular receptor-mediated signaling pathway; regulation of osteoclast differentiation; regulation of transcription, DNA-dependent; regulation of osteoblast differentiation; cartilage development; organelle organization and biogenesis; positive regulation of transcription from RNA polymerase II promoter; steroid hormone mediated signaling; gene expression; negative regulation of transcription from RNA polymerase II promoter; regulation of cell proliferation
Show more

Research Articles on ESRRA

1. ERRalpha can act as a transcriptional activator of Runx2-I in presence of peroxisome proliferator activated receptor gamma coactivator-1 alpha (PGC-1alpha).

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-ESRRA antibody

 Reference Product  PubMed Publications
 PPARGC1A antibody  >5 publications with ESRRA and PPARGC1A
 ESR1 antibody  >1 publications with ESRRA and ESR1

Pathways associated with anti-ESRRA antibody

 Products by Pathway  Pathway Diagram
 Energy Metabolism Pathway antibodies  Energy Metabolism Pathway Diagram
 Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway antibodies  Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Generic Transcription Pathway antibodies  Generic Transcription Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
 Mitochondrial Gene Expression Pathway antibodies  Mitochondrial Gene Expression Pathway Diagram
 Nuclear Receptor Transcription Pathway antibodies  Nuclear Receptor Transcription Pathway Diagram
 Nuclear Receptors Pathway antibodies  Nuclear Receptors Pathway Diagram
 PPARA Activates Gene Expression Pathway antibodies  PPARA Activates Gene Expression Pathway Diagram

Diseases associated with anti-ESRRA antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >6 publications with ESRRA and Neoplasms
 Ovarian Neoplasms Antibodies  >3 publications with ESRRA and Ovarian Neoplasms
 Nervous System Diseases Antibodies  >3 publications with ESRRA and Nervous System Diseases
 Fatty Liver Antibodies  >2 publications with ESRRA and Fatty Liver
 Adenocarcinoma Antibodies  >2 publications with ESRRA and Adenocarcinoma
 Uterine Neoplasms Antibodies  >2 publications with ESRRA and Uterine Neoplasms
 Metabolic Diseases Antibodies  >2 publications with ESRRA and Metabolic Diseases
 Uterine Cervical Neoplasms Antibodies  >1 publications with ESRRA and Uterine Cervical Neoplasms
 Weight Loss Antibodies  >1 publications with ESRRA and Weight Loss
 Endometrial Neoplasms Antibodies  >1 publications with ESRRA and Endometrial Neoplasms

Organs/Tissues associated with anti-ESRRA antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >4 publications with ESRRA and Blood
 Bone Antibodies  >3 publications with ESRRA and Bone
 Brain Antibodies  >3 publications with ESRRA and Brain
 Liver Antibodies  >2 publications with ESRRA and Liver
 Embryonic Tissue Antibodies  >2 publications with ESRRA and Embryonic Tissue
 Thyroid Antibodies  >2 publications with ESRRA and Thyroid
 Spleen Antibodies  >1 publications with ESRRA and Spleen
 Heart Antibodies  >1 publications with ESRRA and Heart
 Muscle Antibodies  >1 publications with ESRRA and Muscle
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000