CCR2 Antibody – Rat Monoclonal

This gene encodes two isoforms of a receptor for monocyte chemoattractant protein-1, a chemokine which specifically mediates monocyte chemotaxis. Monocyte chemoattractant protein-1 is involved in monocyte infiltration in inflammatory diseases such as rheumatoid arthritis as well as in the inflammatory response against tumors. The receptors encoded by this gene mediate agonist-dependent calcium mobilization and inhibition of adenylyl cyclase. This gene is located in the chemokine receptor gene cluster region. Two alternatively spliced transcript variants are expressed by the gene. [provided by RefSeq]

CCR2: a seven transmembrane protein closely related to CCR1. Receptor for the MCP-1, MCP-3 and MCP-4 chemokines. Expressed at high levels in primary neutrophils and primary monocytes, and is further upregulated on neutrophil activation and during monocyte to macrophage differentiation. Transduces a signal by increasing the intracellular calcium ions level. Alternative co receptor with CD4 for HIV-1 infection. Two splice-variant isoforms have been described.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR; GPCR, family 1

Chromosomal Location of Human Ortholog: 3p21.31

Cellular Component: cell soma; perinuclear region of cytoplasm; integral to plasma membrane; dendrite; cytoplasm; integral to membrane; plasma membrane; perikaryon; cytosol

Molecular Function: protein homodimerization activity; CCR2 chemokine receptor binding; C-C chemokine receptor activity; chemokine receptor activity

Biological Process: positive regulation of tumor necrosis factor biosynthetic process; viral reproduction; positive regulation of T-helper 1 type immune response; cytokine and chemokine mediated signaling pathway; negative regulation of adenylate cyclase activity; chemotaxis; JAK-STAT cascade; cellular calcium ion homeostasis; G-protein coupled receptor protein signaling pathway; elevation of cytosolic calcium ion concentration; negative regulation of angiogenesis; positive regulation of interferon-gamma production; negative regulation of T-helper 2 type immune response; positive regulation of interleukin-2 production; response to wounding; dendritic cell chemotaxis; innate immune response; cellular defense response; immune response; positive regulation of alpha-beta T cell proliferation; blood vessel remodeling; negative regulation of eosinophil degranulation; cellular homeostasis; positive regulation of T cell activation; inflammatory response; positive regulation of inflammatory response