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NTHL1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6326993

The protein encoded by this gene is a DNA N-glycosylase of the endonuclease III family. Like a similar protein in E. coli, the encoded protein has DNA glycosylase activity on DNA substrates containing oxidized pyrimidine residues and has apurinic/apyrimidinic… More details

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Product Overview

Online Datasheet in PDF
Product Name
NTHL1, Polyclonal Antibody
Full Product Name
NTHL1, ID (R103) (NTHL1, NTH1, OCTS3, Endonuclease III-like protein 1) (MaxLight 650)
Product Gene Name
anti-NTHL1 antibody
Product Synonym Names
NTHL1; NTH1; OCTS3; Endonuclease III-like protein 1
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight650.
Purity/Purification
Purified by Protein A Affinity Chromatography.
Preparation and Storage
Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: MaxLight650 conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight
32,839 Da
OMIM
602656
3D Structure
ModBase 3D Structure for P78549
Immunogen
NTHL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 95-126 amino acids from the Central region of human NTHL1.
Conjugate
MaxLight650
Note
Preservative Free

Product Categories/Family for anti-NTHL1 antibody

Antibodies; Enzymes; Endonuclease
Applications Tested/Suitable for anti-NTHL1 antibody
Western Blot (WB), FLISA
Application Notes for anti-NTHL1 antibody
WB: 1:100-500
FLISA: 1:1,000
Applications are based on unconjugated antibody.

Product References and Citations for anti-NTHL1 antibody

Wang, W., et al. Nucleic Acids Res. (2010). In press: Arora, M., et al. Leukemia 24(8):1470-1475(2010). Thyagarajan, B., et al. Biol. Blood Marrow Transplant. 16(8):1084-1089(2010). Briggs, F.B., et al. Am. J. Epidemiol. 172(2):217-224(2010). Goto, M., et al. Carcinogenesis 30(8):1345-1352(2009).

Other Notes

Small volumes of anti-NTHL1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for NTHL1 purchase

MBS6326993 is an antibody targeting NTHL1. Also known as NTHL1, ID (R103) (NTHL1, NTH1, OCTS3, Endonuclease III-like protein 1) (MaxLight 650). Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for NTHL1. It may not necessarily be applicable to this product.

NCBI GI #
4505471
NCBI GeneID
4913
NCBI Accession #
NP_002519.1
UniProt Primary Accession #
P78549
UniProt Secondary Accession #
Q1MVR1; Q99566; Q99794; Q9BPX2
UniProt Related Accession #
P78549
GenBank Nucleotide #
NM_002528.5
NCBI Official Full Name
endonuclease III-like protein 1
NCBI Official Synonym Full Names
nth endonuclease III-like 1 (E. coli)
NCBI Official Symbol
NTHL1
NCBI Official Synonym Symbols
NTH1; OCTS3; hNTH1
UniProt Protein Name
Endonuclease III-like protein 1
UniProt Synonym Protein Names
Bifunctional DNA N-glycoslyase/DNA-(apurinic or apyrimidinic site) lyase
Protein Family
Endonuclease III-like protein
UniProt Gene Name
NTHL1
UniProt Synonym Gene Names
hNTH1
UniProt Entry Name
NTH_HUMAN
NCBI Protein Information
endonuclease III-like protein 1; DNA glycoslyase/AP lyase; NTHL1; bifunctional DNA N-glycoslyase/DNA-(apurinic or apyrimidinic site) lyase

UniProt Comments for NTHL1

NTHL1: Has both an apurinic and/or apyrimidinic endonuclease activity and a DNA N-glycosylase activity. Incises damaged DNA at cytosines, thymines and guanines. Acts on a damaged strand, 5' from the damaged site. Required for the repair of both oxidative DNA damage and spontaneous mutagenic lesions. Belongs to the Nth/MutY family.

Protein type: DNA repair, damage; Hydrolase; Mitochondrial; EC 4.2.99.18; Lyase

Chromosomal Location of Human Ortholog: 16p13.3

Cellular Component: nucleoplasm; mitochondrion; nucleus

Molecular Function: protein binding; DNA-(apurinic or apyrimidinic site) lyase activity; endonuclease activity; metal ion binding; 4 iron, 4 sulfur cluster binding; double-stranded DNA binding; DNA N-glycosylase activity

Biological Process: base-excision repair, AP site formation; base-excision repair; depyrimidination; DNA repair; nucleotide-excision repair, DNA incision, 5'-to lesion; DNA catabolic process, endonucleolytic

Disease: Familial Adenomatous Polyposis 3
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Research Articles on NTHL1

1. we demonstrated that hNEIL1 and hNTH1 cleave Oz sites as efficiently as 5-hydroxyuracil sites. Thus, hNEIL1 and hNTH1 can repair Oz lesions

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-NTHL1 antibody

 Reference Product  PubMed Publications
 NEIL1 antibody  >18 publications with NTHL1 and NEIL1
 OGG1 antibody  >16 publications with NTHL1 and OGG1
 NEIL2 antibody  >9 publications with NTHL1 and NEIL2
 APEX1 antibody  >6 publications with NTHL1 and APEX1
 NUDT1 antibody  >3 publications with NTHL1 and NUDT1
 YBX1 antibody  >2 publications with NTHL1 and YBX1
 XPA antibody  >1 publications with NTHL1 and XPA

Pathways associated with anti-NTHL1 antibody

 Products by Pathway  Pathway Diagram
 Base Excision Repair Pathway antibodies  Base Excision Repair Pathway Diagram
 Base Excision Repair Pathway antibodies  Base Excision Repair Pathway Diagram
 Base Excision Repair Pathway antibodies  Base Excision Repair Pathway Diagram
 Base-Excision Repair, AP Site Formation Pathway antibodies  Base-Excision Repair, AP Site Formation Pathway Diagram
 Base-free Sugar-phosphate Removal Via The Single-nucleotide Replacement Pathway antibodies  Base-free Sugar-phosphate Removal Via The Single-nucleotide Replacement Pathway Diagram
 Cleavage Of The Damaged Pyrimidine Pathway antibodies  Cleavage Of The Damaged Pyrimidine Pathway Diagram
 DNA Repair Pathway antibodies  DNA Repair Pathway Diagram
 Depyrimidination Pathway antibodies  Depyrimidination Pathway Diagram
 Displacement Of DNA Glycosylase By APE1 Pathway antibodies  Displacement Of DNA Glycosylase By APE1 Pathway Diagram
 Recognition And Association Of DNA Glycosylase With Site Containing An Affected Pyrimidine Pathway antibodies  Recognition And Association Of DNA Glycosylase With Site Containing An Affected Pyrimidine Pathway Diagram

Diseases associated with anti-NTHL1 antibody

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >6 publications with NTHL1 and Nervous System Diseases
 Congenital Abnormalities Antibodies  >4 publications with NTHL1 and Congenital Abnormalities
 Neoplasms, Experimental Antibodies  >2 publications with NTHL1 and Neoplasms, Experimental
 Brain Diseases Antibodies  >2 publications with NTHL1 and Brain Diseases
 Ovarian Neoplasms Antibodies  >2 publications with NTHL1 and Ovarian Neoplasms
 Death Antibodies  >2 publications with NTHL1 and Death
 Kidney Diseases Antibodies  >2 publications with NTHL1 and Kidney Diseases
 Lung Diseases Antibodies  >2 publications with NTHL1 and Lung Diseases
 Liver Neoplasms Antibodies  >1 publications with NTHL1 and Liver Neoplasms
 Disease Models, Animal Antibodies  >1 publications with NTHL1 and Disease Models, Animal

Organs/Tissues associated with anti-NTHL1 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >4 publications with NTHL1 and Blood
 Kidney Antibodies  >3 publications with NTHL1 and Kidney
 Liver Antibodies  >3 publications with NTHL1 and Liver
 Lung Antibodies  >3 publications with NTHL1 and Lung
 Lymph Antibodies  >1 publications with NTHL1 and Lymph
 Pharynx Antibodies  >1 publications with NTHL1 and Pharynx
 Muscle Antibodies  >1 publications with NTHL1 and Muscle
 Testis Antibodies  >1 publications with NTHL1 and Testis
 Stomach Antibodies  >1 publications with NTHL1 and Stomach
 Brain Antibodies  >1 publications with NTHL1 and Brain
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