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PRSS2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS6337909

MBS6337909 is an antibody targeting PRSS2. Also known as PRSS2, ID (PRSS2, TRY2, TRYP2, Trypsin-2, Anionic trypsinogen, Serine protease 2, Trypsin II) (APC). Reactive in Human. Host: Rabbit. More details

$1060 / 0.2 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
PRSS2, Polyclonal Antibody
Full Product Name
PRSS2, ID (PRSS2, TRY2, TRYP2, Trypsin-2, Anionic trypsinogen, Serine protease 2, Trypsin II) (APC)
Product Gene Name
anti-PRSS2 antibody
Product Synonym Names
PRSS2; TRY2; TRYP2; Trypsin-2; Anionic trypsinogen; Serine protease 2; Trypsin II
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with Allophycocyanin (APC).
Purity/Purification
Purified by Protein A and Peptide Affinity Chromatography.
Specificity
Recognizes human PRSS2.
Preparation and Storage
Store product at 4 degree C in the dark. DO NOT FREEZE! Stable at 4 degree C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: APC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Molecular Weight
26,488 Da
OMIM
601564
3D Structure
ModBase 3D Structure for P07478
Immunogen
KLH-conjugated synthetic peptide mapping to a fragment of residues within amino acids 80-108 in the central region of human PRSS2, Swiss/UniProt Accession: P07478.
Conjugate
APC
Note
Preservative Free
Special Handling
Light sensitive

Product Categories/Family for anti-PRSS2 antibody

Antibodies; Enzymes; Protease (Proteinase; Peptidase)
Applications Tested/Suitable for anti-PRSS2 antibody
Immunohistochemistry (IHC) Paraffin, Western Blot (WB), FLISA
Application Notes for anti-PRSS2 antibody
Applications are based on unconjugated antibody.

Western Blot (WB) of anti-PRSS2 antibody

Western Blot analysis in NCI-H292 cell line lysates (35ug/lane) usingMBS6004781. This demonstrates that MBS6004781 detected the PRSS2 protein (arrow).
Rabbit Anti-PRSS2 Polyclonal Antibody – Cat# MBS6337909

Immunohistochemistry (IHC) of anti-PRSS2 antibody

Immunohistochemistry analysis in formalin fixed and paraffin embedded human pancreas tissue using MBS6004781 followed by peroxidase conjugation of the secondary antibody and DAB staining. This data demonstrates the use of MBS6004781 for immunohistochemistry.
Rabbit Anti-PRSS2 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS6337909

Product References and Citations for anti-PRSS2 antibody

1. Felderbauer, P., et al. Exp. Clin. Endocrinol. Diabetes (2010). In press 2. Gao, J., et al. Oncol. Rep. 23(6):1683-1692(2010). 3. Cevik, Y., et al. Ulus Travma Acil Cerrahi Derg 16(2):125-129(2010). 4. Andersen, A.M., et al. Pancreas 39(1):26-30(2010). 5. Johansen, D., et al. Pancreatology 10 (2-3), 229-237 (2010).

Other Notes

Small volumes of anti-PRSS2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for PRSS2. It may not necessarily be applicable to this product.

NCBI GI #
4506147
NCBI GeneID
5645
NCBI Accession #
NP_002761.1
UniProt Primary Accession #
P07478
UniProt Related Accession #
P07478
GenBank Nucleotide #
NM_002770.3
NCBI Official Full Name
trypsin-2 isoform 2 preproprotein
NCBI Official Synonym Full Names
serine protease 2
NCBI Official Symbol
PRSS2
NCBI Official Synonym Symbols
TRY2; TRY8; TRYP2
UniProt Protein Name
Trypsin-2
UniProt Synonym Protein Names
Anionic trypsinogen; Serine protease 2; Trypsin II
Protein Family
Anionic trypsin
UniProt Gene Name
PRSS2
UniProt Synonym Gene Names
TRY2; TRYP2
UniProt Entry Name
TRY2_HUMAN
NCBI Protein Information
trypsin-2

NCBI Summary for PRSS2

This gene belongs to the trypsin family of serine proteases and encodes anionic trypsinogen. It is part of a cluster of trypsinogen genes that are located within the T cell receptor beta locus. Enzymes of this family cleave peptide bonds that follow lysine or arginine residues. This protein is found at high levels in pancreatic juice and its upregulation is a characteristic feature of pancreatitis. This protein has also been found to activate pro-urokinase in ovarian tumors, suggesting a function in tumor invasion. In addition, this enzyme is able to cleave across the type II collagen triple helix in rheumatoid arthritis synovitis tissue, potentially participating in the degradation of type II collagen-rich cartilage matrix. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jan 2015]
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UniProt Comments for PRSS2

trypsin 2: In the ileum, may be involved in defensin processing, including DEFA5. Belongs to the peptidase S1 family.

Protein type: Secreted; Extracellular matrix; Secreted, signal peptide; Calcium-binding; EC 3.4.21.4; Protease; Cell adhesion

Chromosomal Location of Human Ortholog: 7q34

Cellular Component: extracellular matrix; extracellular space; extracellular region

Molecular Function: protein binding; serine-type endopeptidase activity; calcium ion binding

Biological Process: extracellular matrix disassembly; collagen catabolic process; extracellular matrix organization and biogenesis; positive regulation of cell adhesion; digestion; innate immune response; proteolysis; positive regulation of cell growth

Disease: Pancreatitis, Hereditary
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Research Articles on PRSS2

1. evaluated the association of claudin2 and PRSS1-PRSS2 polymorphisms with idiopathic recurrent acute (RAP) and chronic pancreatitis

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-PRSS2 antibody

 Products by Pathway  Pathway Diagram
 Activation Of Matrix Metalloproteinases Pathway antibodies  Activation Of Matrix Metalloproteinases Pathway Diagram
 Alpha-defensins Pathway antibodies  Alpha-defensins Pathway Diagram
 Collagen Degradation Pathway antibodies  Collagen Degradation Pathway Diagram
 Defensins Pathway antibodies  Defensins Pathway Diagram
 Degradation Of The Extracellular Matrix Pathway antibodies  Degradation Of The Extracellular Matrix Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Influenza A Pathway antibodies  Influenza A Pathway Diagram
 Influenza A Pathway antibodies  Influenza A Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram

Diseases associated with anti-PRSS2 antibody

 Disease Name  Pubmed Publications
 Pancreatitis, Chronic Antibodies  >51 publications with PRSS2 and Pancreatitis, Chronic
 Fibrosis Antibodies  >27 publications with PRSS2 and Fibrosis
 Pancreatic Neoplasms Antibodies  >14 publications with PRSS2 and Pancreatic Neoplasms
 Adenocarcinoma Antibodies  >10 publications with PRSS2 and Adenocarcinoma
 Inflammation Antibodies  >8 publications with PRSS2 and Inflammation
 Lung Diseases Antibodies  >7 publications with PRSS2 and Lung Diseases
 Liver Neoplasms Antibodies  >2 publications with PRSS2 and Liver Neoplasms
 Diabetes Mellitus Antibodies  >2 publications with PRSS2 and Diabetes Mellitus
 Lung Injury Antibodies  >2 publications with PRSS2 and Lung Injury
 Liver Cirrhosis Antibodies  >2 publications with PRSS2 and Liver Cirrhosis

Organs/Tissues associated with anti-PRSS2 antibody

 Organ/Tissue Name  Pubmed Publications
 Pancreas Antibodies  >35 publications with PRSS2 and Pancreas
 Intestine Antibodies  >4 publications with PRSS2 and Intestine
 Liver Antibodies  >4 publications with PRSS2 and Liver
 Lung Antibodies  >2 publications with PRSS2 and Lung
 Testis Antibodies  >1 publications with PRSS2 and Testis
 Prostate Antibodies  >1 publications with PRSS2 and Prostate
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