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Nerve Growth Factor, 7s (KLK1B4) Active Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS634372

MBS634372 is an active protein targeting Klk1b4. Also known as Nerve Growth Factor, 7S (NGF). Host: Male mouse submaxillary glands. More details

$875 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Nerve Growth Factor, 7S (Klk1b4), Active Protein
Full Product Name
Nerve Growth Factor, 7S (NGF)
Product Gene Name
Host
Male mouse submaxillary glands
Form/Format
Supplied as a liquid.
Purity/Purification
Highly Purified
Purified by gel filtration. Does not contain detectable amounts of EGF
Preparation and Storage
May be stored at 4 degree C for short-term only. For long-term storage, aliquot and store at -20 degree C. Aliquots are stable for 6 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Molecular Weight
130-140kD
Chromosome Location
Chromosome: 7; NC_000073.6 (44207435..44211754). Location: 7 B4; 7 28.72 cM
3D Structure
ModBase 3D Structure for P00757
Active Protein Note
Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.
Biological Activity
Dose for significant outgrowth of neurite using PC-12 rat pheochromocytoma cells: 10ng/ml. 7S NGF has a variety of effects on sensory and sympathetic neuron growth and development. 7S NGF is also needed for sympathetic nerve cells development and maintenance.

Other Notes

Small volumes of Klk1b4 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for Klk1b4. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Related Accession #
NCBI Official Full Name
nerve growth factor 7S alpha subunit
NCBI Official Synonym Full Names
kallikrein 1-related pepidase b4
NCBI Official Symbol
Klk1b4
NCBI Official Synonym Symbols
Ngfa; mGk-4
UniProt Protein Name
Kallikrein 1-related peptidase-like b4
UniProt Synonym Protein Names
7S nerve growth factor alpha chain; Alpha-NGF
UniProt Gene Name
Klk1b4
UniProt Synonym Gene Names
Klk-4; Klk4; Ngfa
UniProt Entry Name
K1KB4_MOUSE
NCBI Protein Information
kallikrein 1-related peptidase-like b4; alpha-NGF; nerve growth factor, alpha; 7S nerve growth factor alpha chain; 7S nerve growth factor alpha subunit

UniProt Comments for Klk1b4

Cofactor: Binds 2 zinc ions per 7S complex. The zinc ions are bound at the alpha-gamma interfaces.

Subunit structure: 7S nerve growth factor is composed of two alpha chains, a beta dimer composed of identical chains, and two gamma chains.

Post-translational modification: The presence of Gln-24 prevents cleavage of the activation peptide, which remains attached at the amino end of the mature alpha chain.

Sequence similarities: Belongs to the peptidase S1 family. Kallikrein subfamily.Contains 1 peptidase S1 domain.

Caution: Has no demonstrable enzymatic activity. This may be due to several critical changes in its sequence, relative to those of related proteases.
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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