Plexin C1 (PLXNC1) Active Protein

Plexin C1, also known as Virus-encoded semaphorin protein receptor (VESPR) and CD232, is a 210kD type I transmembrane glycoprotein in the C subfamily of the plexin family. Human Plexin C1 contains a 34aa signal sequence, a 910aa extracellular domain (ECD) with one Sema­domain and two cysteine­rich Met­related sequences (MRS), a 21aa transmembrane domain and a 603aa cytoplasmic domain that includes features common to other plexins, including a phosphothreonine site. The mouse Plexin C1 ECD shares 85%, 78% and 65% aa identity with human, bovine and equine Plexin C1, respectively. A truncated rat Plexin C1 cDNA that encodes an apparently soluble form shares 93% aa identity with mouse Plexin C1 within aa 263­932. Plexin C1 is widely expressed in neuronal and non­neuronal fetal and adult tissues. In neuronal development, its role is unclear. Semaphorin­7a (Sema7a, CD108) binds Plexin C1 in vitro and the two show a similar expression pattern during rat neuronal development, but beta-1 integrins rather than Plexin C1 appear to mediate Sema7a effects on axon outgrowth. Plexin C1 does appear to play a role in partitioning of paraventricular and supraoptic neurons in the hypothalamus, as indicated by specific defects seen in mice deleted for Plexin C1 In the immune system, effects of Sema7a on T cell­mediated inflammatory responses also appear to be mediated by beta-1 integrins rather than plexins. However, Plexin C1 may function to oppose the effect of beta-1 integrins, as it does on Sema7a- mediated spreading and dendrite formation in melanocytes Its expression is lost in melanoma metastasis, suggesting a role as a tumor suppressor Plexin C1 is the receptor for poxvirus (A39R protein) and herpes virus (AHVsema) semaphorin homologs, and mediates activation of monocytes and inhibition of dendritic cell and neutrophil phagocytosis and migration by A39R.

Small volumes of PLXNC1 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS635720 is an active protein targeting PLXNC1. Also known as Plexin C1, Recombinant, Mouse (Plexin-C1, Virus-encoded Semaphorin Protein Receptor, CD232, PLXNC1, VESPR).