P27 Complex, Activated (INPP5D) Recombinant Protein

SHIP: an SH2-containing inositol phosphatase. A hemopoietic-specific phosphatase that regulates cell survival, growth, cell cycle arrest and apoptosis. Hydrolyzes Ins(1,3,4,5)P4 and PtdIns(3,4,5)P3. A cytosolic protein with a SH2 domain in its N-terminus and two NPXY Shc binding motifs at its C-terminus. Upon receptor cross-linking, SHIP is first recruited to the plasma membrane by its SH2, followed by tyrosine phosphorylation on the NPXY motif. Both membrane relocalization and phosphorylation are essential for its regulatory function. Associates with SHC after cytokine stimulation.

Protein type: EC 3.1.3.86; Phosphatase, lipid; Motility/polarity/chemotaxis

Cellular Component: cortical cytoskeleton; membrane; cytoplasm; plasma membrane; actin filament; intracellular; cytosol

Molecular Function: protein binding; hydrolase activity; PTB domain binding; inositol-4,5-bisphosphate 5-phosphatase activity; inositol-polyphosphate 5-phosphatase activity; SH3 domain binding

Biological Process: negative regulation of osteoclast differentiation; positive regulation of apoptosis; apoptosis; immune system process; positive regulation of erythrocyte differentiation; negative regulation of immune response; negative regulation of B cell activation; negative regulation of interleukin-6 biosynthetic process; negative regulation of B cell proliferation; determination of adult life span; negative regulation of monocyte differentiation; negative regulation of neutrophil differentiation; negative regulation of granulocyte differentiation; negative regulation of signal transduction; positive regulation of lymphocyte differentiation; negative regulation of cell proliferation; dephosphorylation; phosphoinositide dephosphorylation; positive regulation of B cell differentiation; immunoglobulin mediated immune response; negative regulation of bone resorption