Human GPC3 cDNA Clone Expression Plasmid – Cat# MBS1266389

GPC3 cDNA Clone – Glypican 3 (Human)

Name: GPC3 cDNA Clone; Glypican 3; Human; MyBioSource
Brand: MyBioSource
SKU: MBS1266389
Price: 235 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1266389

MBS1266389 is a cDNA clone targeting GPC3. More details

$235 / 0.01 mg Plasmid + 0.2 mL Glycerol-Stock +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

GPC3, cDNA Clone

Full Product Name

GPC3 cDNA Clone

Product Gene Name

GPC3 cdna clone

Sequence

atggccggga ccgtgcgcac cgcgtgcttg gtggtggcga tgctgctcag cttggacttc ccgggacagg cgcagccccc gccgccgccg ccggacgcca cctgtcacca agtccgctcc ttcttccaga gactgcagcc cggactcaag tgggtgccag aaactcccgt gccaggatca gatttgcaag tatgtctccc taagggccca acatgctgct caagaaagat ggaagaaaaa taccaactaa cagcacgatt gaacatggaa cagctgcttc agtctgcaag tatggagctc aagttcttaa ttattcagaa tgctgcggtt ttccaagagg cctttgaaat tgttgttcgc catgccaaga actacaccaa tgccatgttc aagaacaact acccaagcct gactccacaa gcttttgagt ttgtgggtga atttttcaca gatgtgtctc tctacatctt gggttctgac atcaatgtag atgacatggt caatgaattg tttgacagcc tgtttccagt catctatacc cagctaatga acccaggcct gcctgattca gccttggaca tcaatgagtg cctccgagga gcaagacgtg acctgaaagt atttgggaat ttccccaagc ttattatgac ccaggtttcc aagtcactgc aagtcactag gatcttcctt caggctctga atcttggaat tgaagtgatc aacacaactg atcacctgaa gttcagtaag gactgtggcc gaatgctcac cagaatgtgg tactgctctt actgccaggg actgatgatg gttaaaccct gtggcggtta ctgcaatgtg gtcatgcaag gctgtatggc aggtgtggtg gagattgaca agtactggag agaatacatt ctgtcccttg aagaacttgt gaatggcatg tacagaatct atgacatgga gaacgtactg cttggtctct tttcaacaat ccatgattct atccagtatg tccagaagaa tgcaggaaag ctgaccacca ctattggcaa gttatgtgcc cattctcaac aacgccaata tagatttgct tattatcctg aagatctctt tattgacaag aaagtattaa aagttgctca tgtagaacat gaagaaacct tatccagccg aagaagggaa ctaattcaga agttgaagtc tttcatcagc ttctatagtg ctttgcctgg ctacatctgc agccatagcc ctgtggcgga aaacgacacc ctttgctgga atggacaaga actcgtggag agatacagcc aaaaggcagc aaggaatgga atgaaaaacc agttcaatct ccatgagctg aaaatgaagg gccctgagcc agtggtcagt caaattattg acaaactgaa gcacattaac cagctcctga gaaccatgtc tatgcccaaa ggtagagttc tggataaaaa cctggatgag gaagggtttg aaagtggaga ctgcggtgat gatgaagatg agtgcattgg aggctctggt gatggaatga taaaagtgaa gaatcagctc cgcttccttg cagaactggc ctatgatctg gatgtggatg atgcgcctgg aaacagtcag caggcaactc cgaaggacaa cgagataagc acctttcaca acctcgggaa cgttcattcc ccgctgaagc ttctcaccag catggccatc tcggtggtgt gcttcttctt cctggtgcac tga

Molecular Weight

68,414 Da

OMIM

300037

Vector

pENTR223.1

Clone Sequence Report

Provided with product shipment

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of GPC3 cdna clone vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for GPC3. It may not necessarily be applicable to this product.

NCBI GI #

23271173

NCBI GeneID

2719

NCBI Accession #

BC035972

UniProt Secondary Accession #

Q2L880; Q2L882; C9JLE3; G3V1R0

UniProt Related Accession #

P51654

NCBI Official Full Name

Homo sapiens glypican 3, mRNA

NCBI Official Synonym Full Names

glypican 3

NCBI Official Symbol

GPC3

NCBI Official Synonym Symbols

SGB; DGSX; MXR7; SDYS; SGBS; OCI-5; SGBS1; GTR2-2

UniProt Protein Name

Glypican-3

UniProt Synonym Protein Names

GTR2-2; Intestinal protein OCI-5; MXR7

Protein Family

Glypican

UniProt Gene Name

GPC3

UniProt Synonym Gene Names

OCI5

UniProt Entry Name

GPC3_HUMAN

NCBI Protein Information

glypican-3

NCBI Summary for GPC3

Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation. The protein encoded by this gene can bind to and inhibit the dipeptidyl peptidase activity of CD26, and it can induce apoptosis in certain cell types. Deletion mutations in this gene are associated with Simpson-Golabi-Behmel syndrome, also known as Simpson dysmorphia syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009]

UniProt Comments for GPC3

Cell surface proteoglycan that bears heparan sulfate. Inhibits the dipeptidyl peptidase activity of DPP4. May be involved in the suppression/modulation of growth in the predominantly mesodermal tissues and organs. May play a role in the modulation of IGF2 interactions with its receptor and thereby modulate its function. May regulate growth and tumor predisposition.

Research Articles on GPC3

1. GPC3 expression was measured in hepatocellular carcinoma at different stages and correlated with prognosis. CK19+/GPC3+ HCC has the highest risk of intrahepatic metastasis, microvascular invasion, regional lymph node involvement, and distant metastasis.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with GPC3 cdna clone

Products by Pathway	Pathway Diagram
A Tetrasaccharide Linker Sequence Is Required For GAG Synthesis Pathway antibodies	A Tetrasaccharide Linker Sequence Is Required For GAG Synthesis Pathway Diagram
Chondroitin Sulfate/dermatan Sulfate Metabolism Pathway antibodies	Chondroitin Sulfate/dermatan Sulfate Metabolism Pathway Diagram
Disease Pathway antibodies	Disease Pathway Diagram
Diseases Associated With Visual Transduction Pathway antibodies	Diseases Associated With Visual Transduction Pathway Diagram
Glycosaminoglycan Metabolism Pathway antibodies	Glycosaminoglycan Metabolism Pathway Diagram
Glypican 3 Network Pathway antibodies	Glypican 3 Network Pathway Diagram
Glypican Pathway antibodies	Glypican Pathway Diagram
HS-GAG Biosynthesis Pathway antibodies	HS-GAG Biosynthesis Pathway Diagram
HS-GAG Degradation Pathway antibodies	HS-GAG Degradation Pathway Diagram
Heparan Sulfate/heparin (HS-GAG) Metabolism Pathway antibodies	Heparan Sulfate/heparin (HS-GAG) Metabolism Pathway Diagram

Diseases associated with GPC3 cdna clone

Disease Name	Pubmed Publications
Neoplasms Antibodies	>284 publications with GPC3 and Neoplasms
Carcinoma, Hepatocellular Antibodies	>198 publications with GPC3 and Carcinoma, Hepatocellular
Liver Neoplasms Antibodies	>171 publications with GPC3 and Liver Neoplasms
Liver Diseases Antibodies	>170 publications with GPC3 and Liver Diseases
SIMPSON-GOLABI-BEHMEL SYNDROME, TYPE 1 Antibodies	>75 publications with GPC3 and SIMPSON-GOLABI-BEHMEL SYNDROME, TYPE 1
Liver Cirrhosis Antibodies	>40 publications with GPC3 and Liver Cirrhosis
Hepatitis Antibodies	>36 publications with GPC3 and Hepatitis
Lung Neoplasms Antibodies	>24 publications with GPC3 and Lung Neoplasms
Adenoma Antibodies	>20 publications with GPC3 and Adenoma
Wilms Tumor Antibodies	>19 publications with GPC3 and Wilms Tumor

Organs/Tissues associated with GPC3 cdna clone

Organ/Tissue Name	Pubmed Publications
Liver Antibodies	>196 publications with GPC3 and Liver
Blood Antibodies	>84 publications with GPC3 and Blood
Bone Antibodies	>47 publications with GPC3 and Bone
Embryonic Tissue Antibodies	>39 publications with GPC3 and Embryonic Tissue
Brain Antibodies	>37 publications with GPC3 and Brain
Kidney Antibodies	>36 publications with GPC3 and Kidney
Lung Antibodies	>30 publications with GPC3 and Lung
Vascular Antibodies	>25 publications with GPC3 and Vascular
Heart Antibodies	>19 publications with GPC3 and Heart
Muscle Antibodies	>19 publications with GPC3 and Muscle