ALDH3A1 Recombinant Protein – Cat# MBS636817

15% SDS-PAGE (3ug)

ALDH3A1 Human (ALDH3A1) Recombinant Protein

Name: ALDH3A1 Recombinant Protein; ALDH3A1 Human; Human; MyBioSource
Brand: MyBioSource
SKU: MBS636817
Price: 755 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS636817

ALDH3A1, also known as Aldehyde dehydrogenase 3 family memberA1, is involved in the detoxification of alcohol-derived acetaldehyde and in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. This protein forms a… More details

$755 / 0.05 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

ALDH3A1 Human, Recombinant Protein

Full Product Name

ALDH3A1, Recombinant Human (Aldehyde dehydrogenase 3 family, memberA1)

Product Gene Name

ALDH3A1 recombinant protein

Sequence

MGSSHHHHHH SSGLVPRGSH MSKISEAVKR ARAAFSSGRT RPLQFRIQQL EALQRLIQEQ EQELVGALAA DLHKNEWNAY YEEVVYVLEE IEYMIQKLPE WAADEPVEKT PQTQQDELYI HSEPLGVVLV IGTWNYPFNL TIQPMVGAIA AGNAVVLKPS ELSENMASLL ATIIPQYLDK
DLYPVI NGGV PETTELLKER FDHILYTGST GVGKIIMTAA AKHLTPVTLE LGGKSPCYVD KNCDLDVACR RIAWGKFMNS GQTCVAPDYI LCDPSIQNQI VEKLKKSLKE FYGEDAKKSR DYGRIISARH FQRVMGLIEG QKVAYGGTGD AATRYIAPTI LTDVDPQSPV MQEEIFGPVL IVCVRSLEE AIQFINQREK PLALYMFSSN DKVIKKMIAE TSSGGVAAND VIVHITLHSL PFGGVGNSGM GSYHGKKSFE TFSHRRSCLV RPLMNDEGLK VRYPPSPAKM TQH

Host

E Coli

Form/Format

Supplied as a liquid in 20mM Tris-HCl buffer, pH8.0,10% glycerol, 0.1M NaCl.

Purity/Purification

Affinity Purified
~95% by SDS-PAGE.

Preparation and Storage

May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 6 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Molecular Weight

52.5kD

Chromosome Location

Chromosome: 17; NC_000017.10 (19641297..19651746, complement). Location: 17p11.2

OMIM

100660

3D Structure

ModBase 3D Structure for P30838

Endotoxin Level

1EU/1ug (LAL).

Product Categories/Family for ALDH3A1 recombinant protein

Molecular Biology; MB-Proteins

Applications Tested/Suitable for ALDH3A1 recombinant protein

Western Blot (WB)

Application Notes for ALDH3A1 recombinant protein

Suitable for use in Western Blot.

Other Notes

Small volumes of ALDH3A1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ALDH3A1 purchase

MBS636817 is a recombinant protein targeting ALDH3A1. Also known as ALDH3A1, Recombinant Human (Aldehyde dehydrogenase 3 family, memberA1). Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for ALDH3A1. It may not necessarily be applicable to this product.

NCBI GI #

206597441

NCBI GeneID

218

NCBI Accession #

NP_001128640.1

UniProt Primary Accession #

P30838

UniProt Secondary Accession #

Q9BT37; A8K828

UniProt Related Accession #

P30838

GenBank Nucleotide #

NM_001135168.1

NCBI Official Full Name

aldehyde dehydrogenase, dimeric NADP-preferring

NCBI Official Synonym Full Names

aldehyde dehydrogenase 3 family, member A1

NCBI Official Symbol

ALDH3A1

NCBI Official Synonym Symbols

ALDH3; ALDHIII

UniProt Protein Name

Aldehyde dehydrogenase, dimeric NADP-preferring

UniProt Synonym Protein Names

ALDHIII; Aldehyde dehydrogenase 3; Aldehyde dehydrogenase family 3 member A1

Protein Family

Aldehyde dehydrogenase

UniProt Gene Name

ALDH3A1

UniProt Synonym Gene Names

ALDH3

UniProt Entry Name

AL3A1_HUMAN

NCBI Protein Information

aldehyde dehydrogenase, dimeric NADP-preferring; stomach aldehyde dehydrogenase; aldehyde dehydrogenase type III; aldehyde dehydrogenase isozyme 3

NCBI Summary for ALDH3A1

Aldehyde dehydrogenases oxidize various aldehydes to the corresponding acids. They are involved in the detoxification of alcohol-derived acetaldehyde and in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. The enzyme encoded by this gene forms a cytoplasmic homodimer that preferentially oxidizes aromatic and medium-chain (6 carbons or more) saturated and unsaturated aldehyde substrates. It is thought to promote resistance to UV and 4-hydroxy-2-nonenal-induced oxidative damage in the cornea. The gene is located within the Smith-Magenis syndrome region on chromosome 17. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Sep 2008]

UniProt Comments for ALDH3A1

ALDH3A1: ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. This protein preferentially oxidizes aromatic aldehyde substrates. It may play a role in the oxidation of toxic aldehydes. Belongs to the aldehyde dehydrogenase family.

Protein type: Xenobiotic Metabolism - drug metabolism - cytochrome P450; Xenobiotic Metabolism - metabolism by cytochrome P450; Amino Acid Metabolism - tyrosine; EC 1.2.1.5; Amino Acid Metabolism - phenylalanine; Oxidoreductase; Amino Acid Metabolism - histidine; Carbohydrate Metabolism - glycolysis and gluconeogenesis

Chromosomal Location of Human Ortholog: 17p11.2

Cellular Component: nucleoplasm; extracellular space; intracellular membrane-bound organelle; endoplasmic reticulum; cytoplasm; plasma membrane; cytosol

Molecular Function: aldehyde dehydrogenase (NAD) activity; aldehyde dehydrogenase [NAD(P)+] activity; 3-chloroallyl aldehyde dehydrogenase activity; alcohol dehydrogenase (NADP+) activity

Biological Process: response to drug; response to cAMP; positive regulation of cell proliferation; response to glucocorticoid stimulus; response to hypoxia; aldehyde metabolic process; response to nutrient; aging

Research Articles on ALDH3A1

1. ALDH3A1 provides exceptional protection from the adverse effects of pathophysiological concentrations of 4-HNE such as may occur during periods of oxidative stress

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with ALDH3A1 recombinant protein

Reference Product	PubMed Publications
GSTA1 recombinant protein	>6 publications with ALDH3A1 and GSTA1
GSTP1 recombinant protein	>4 publications with ALDH3A1 and GSTP1
CYP2B6 recombinant protein	>4 publications with ALDH3A1 and CYP2B6
ADH4 recombinant protein	>3 publications with ALDH3A1 and ADH4
ADH1B recombinant protein	>3 publications with ALDH3A1 and ADH1B
GSTM1 recombinant protein	>2 publications with ALDH3A1 and GSTM1
ADH7 recombinant protein	>2 publications with ALDH3A1 and ADH7

Pathways associated with ALDH3A1 recombinant protein

Products by Pathway	Pathway Diagram
AhR Pathway antibodies	AhR Pathway Diagram
Chemical Carcinogenesis Pathway antibodies	Chemical Carcinogenesis Pathway Diagram
Chemical Carcinogenesis Pathway antibodies	Chemical Carcinogenesis Pathway Diagram
Drug Metabolism - Cytochrome P450 Pathway antibodies	Drug Metabolism - Cytochrome P450 Pathway Diagram
Drug Metabolism - Cytochrome P450 Pathway antibodies	Drug Metabolism - Cytochrome P450 Pathway Diagram
Glycolysis / Gluconeogenesis Pathway antibodies	Glycolysis / Gluconeogenesis Pathway Diagram
Glycolysis / Gluconeogenesis Pathway antibodies	Glycolysis / Gluconeogenesis Pathway Diagram
Histidine Metabolism Pathway antibodies	Histidine Metabolism Pathway Diagram
Histidine Metabolism Pathway antibodies	Histidine Metabolism Pathway Diagram
Metabolism Of Xenobiotics By Cytochrome P450 Pathway antibodies	Metabolism Of Xenobiotics By Cytochrome P450 Pathway Diagram

Diseases associated with ALDH3A1 recombinant protein

Disease Name	Pubmed Publications
Neoplasms Antibodies	>38 publications with ALDH3A1 and Neoplasms
Carcinoma Antibodies	>14 publications with ALDH3A1 and Carcinoma
Lung Diseases Antibodies	>13 publications with ALDH3A1 and Lung Diseases
Lung Neoplasms Antibodies	>13 publications with ALDH3A1 and Lung Neoplasms
Breast Neoplasms Antibodies	>10 publications with ALDH3A1 and Breast Neoplasms
Liver Neoplasms Antibodies	>5 publications with ALDH3A1 and Liver Neoplasms
Carcinoma, Squamous Cell Antibodies	>5 publications with ALDH3A1 and Carcinoma, Squamous Cell
Liver Diseases Antibodies	>4 publications with ALDH3A1 and Liver Diseases
Stomach Neoplasms Antibodies	>4 publications with ALDH3A1 and Stomach Neoplasms
Inflammation Antibodies	>3 publications with ALDH3A1 and Inflammation

Organs/Tissues associated with ALDH3A1 recombinant protein

Organ/Tissue Name	Pubmed Publications
Eye Antibodies	>34 publications with ALDH3A1 and Eye
Lung Antibodies	>19 publications with ALDH3A1 and Lung
Liver Antibodies	>12 publications with ALDH3A1 and Liver
Stomach Antibodies	>9 publications with ALDH3A1 and Stomach
Intestine Antibodies	>4 publications with ALDH3A1 and Intestine
Skin Antibodies	>4 publications with ALDH3A1 and Skin
Mouth Antibodies	>3 publications with ALDH3A1 and Mouth
Brain Antibodies	>2 publications with ALDH3A1 and Brain
Testis Antibodies	>1 publications with ALDH3A1 and Testis
Salivary Gland Antibodies	>1 publications with ALDH3A1 and Salivary Gland