Macrophage Inammatory Protein 3 Alpha (CCL20) Active Protein

Name: CCL20 Active Protein; MyBioSource
Brand: MyBioSource
SKU: MBS636818
Price: 605 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS636818

Murine macrophage inflammatory protein-3a (MIP-3 a, Exodus, LARC) is a member of the b-chemokine (C-C) family of cytokines. Recombinant murine MIP-3 a is a 7.9kD protein containing 70aa residues. More details

$605 / 0.02 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Macrophage Inammatory Protein 3 alpha (CCL20), Active Protein

Full Product Name

Macrophage Inammatory Protein 3 alpha, Recombinant, Mouse (MIP-3-alpha, C-C Motif Chemokine 20, Beta-chemokine Exodus-1, CC Chemokine LARC, CC Chemokine ST38, Liver and Activation-regulated Chemokine, Small-inducible Cytokine A20, Ccl20, Larc, Scya20)

Product Gene Name

CCL20 active protein

Product Synonym Names

Macrophage In ammatory Protein 3 alpha, Recombinant, Mouse (MIP-3-alpha, C-C Motif Chemokine 20, Beta-chemokine Exodus-1, CC Chemokine LARC, CC Chemokine ST38, Liver and Activation-regulated Chemokine, Small-inducible Cytokine A20, Ccl20, Larc, Scya20)

Form/Format

Supplied as a lyophilized powder. Reconstitute with sterile dH2O to 0.1-1mg/ml.

Purity/Purification

Highly Purified
~95% (HPLC, SDS-PAGE)

Preparation and Storage

Lyophilized powder may be stored at -20 degree C. Stable for 12 months at -20 degree C. Reconstitute with dH2O. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Reconstituted product is stable for 6 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Molecular Weight

~7.9kD

Chromosome Location

Chromosome: 2; NC_000002.11 (228678558..228682280). Location: 2q36.3

OMIM

601960

3D Structure

ModBase 3D Structure for P78556

Active Protein Note

Protein activity can be an ambiguous term. Please refer to the data sheet or inquire with Technical Support to determine the definition of activity for this product.

Biological Activity

Calculated by the ability to chemoattract mouse CCR6 transfected HEK/293 cells at a concentration of 0.1-10ng/ml.

Endotoxin Level

<0.1ng/ug

Product Categories/Family for CCL20 active protein

Growth Factors; Cytokines; Growth Factors-MIP

Other Notes

Small volumes of CCL20 active protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CCL20 purchase

MBS636818 is an active protein targeting CCL20. Also known as Macrophage Inammatory Protein 3 alpha, Recombinant, Mouse (MIP-3-alpha, C-C Motif Chemokine 20, Beta-chemokine Exodus-1, CC Chemokine LARC, CC Chemokine ST38, Liver and Activation-regulated Chemokine, Small-inducible Cytokine A20, Ccl20, Larc, Scya20).

Additional Details

NCBI/Uniprot data below describe general gene information for CCL20. It may not necessarily be applicable to this product.

NCBI GI #

1790925

NCBI GeneID

6364

NCBI Accession #

AAC50943.1

UniProt Primary Accession #

P78556

UniProt Secondary Accession #

Q53S51; Q99664

UniProt Related Accession #

P78556

NCBI Official Full Name

macrophage inflammatory protein 3 alpha

NCBI Official Synonym Full Names

chemokine (C-C motif) ligand 20

NCBI Official Symbol

CCL20

NCBI Official Synonym Symbols

CKb4; LARC; ST38; MIP3A; MIP-3a; SCYA20; MIP-3-alpha

UniProt Protein Name

C-C motif chemokine 20

UniProt Synonym Protein Names

Beta-chemokine exodus-1; CC chemokine LARC; Liver and activation-regulated chemokine; Macrophage inflammatory protein 3 alpha; MIP-3-alpha; Small-inducible cytokine A20

Protein Family

C-C motif chemokine

UniProt Gene Name

CCL20

UniProt Synonym Gene Names

LARC; MIP3A; SCYA20; MIP-3-alpha

UniProt Entry Name

CCL20_HUMAN

NCBI Protein Information

C-C motif chemokine 20; CC chemokine LARC; beta chemokine exodus-1; small-inducible cytokine A20; macrophage inflammatory protein 3 alpha; liver and activation-regulated chemokine; small inducible cytokine subfamily A (Cys-Cys), member 20

NCBI Summary for CCL20

This antimicrobial gene belongs to the subfamily of small cytokine CC genes. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The protein encoded by this gene displays chemotactic activity for lymphocytes and can repress proliferation of myeloid progenitors. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2014]

UniProt Comments for CCL20

CCL20: Chemotactic factor that attracts lymphocytes and, slightly, neutrophils, but not monocytes. Inhibits proliferation of myeloid progenitors in colony formation assays. May be involved in formation and function of the mucosal lymphoid tissues by attracting lymphocytes and dendritic cells towards epithelial cells. C-terminal processed forms have been shown to be equally chemotactically active for leukocytes. Possesses antibacterial activity E.coli 25922 and S.aureus 29213. Belongs to the intercrine beta (chemokine CC) family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Secreted, signal peptide; Motility/polarity/chemotaxis; Chemokine

Chromosomal Location of Human Ortholog: 2q36.3

Cellular Component: extracellular space; extracellular region

Molecular Function: protein binding; chemokine activity

Biological Process: cell-cell signaling; wound healing; defense response to bacterium; immune response; signal transduction; chemotaxis; positive regulation of interleukin-1 alpha biosynthetic process; inflammatory response; positive regulation of nitric-oxide synthase biosynthetic process

Research Articles on CCL20

1. In summary, tumor cells exchange signals with the surrounding healthy cells modifying the extracellular matrix through enzyme secretion; thus, CCL20 might be a factor involved in the ontogeny of breast carcinoma.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with CCL20 active protein

Reference Product	PubMed Publications
CCR6 active protein	>337 publications with CCL20 and CCR6
CXCL10 active protein	>95 publications with CCL20 and CXCL10
CCL5 active protein	>83 publications with CCL20 and CCL5
CXCL1 active protein	>79 publications with CCL20 and CXCL1
CXCL2 active protein	>61 publications with CCL20 and CXCL2
CCR7 active protein	>57 publications with CCL20 and CCR7
CXCL9 active protein	>52 publications with CCL20 and CXCL9
CXCL3 active protein	>33 publications with CCL20 and CXCL3
CCR5 active protein	>32 publications with CCL20 and CCR5
CCL25 active protein	>17 publications with CCL20 and CCL25

Pathways associated with CCL20 active protein

Products by Pathway	Pathway Diagram
Chemokine Receptors Bind Chemokines Pathway antibodies	Chemokine Receptors Bind Chemokines Pathway Diagram
Chemokine Signaling Pathway antibodies	Chemokine Signaling Pathway Diagram
Chemokine Signaling Pathway antibodies	Chemokine Signaling Pathway Diagram
Class A/1 (Rhodopsin-like Receptors) Pathway antibodies	Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
EBV LMP1 Signaling Pathway antibodies	EBV LMP1 Signaling Pathway Diagram
G Alpha (i) Signalling Events Pathway antibodies	G Alpha (i) Signalling Events Pathway Diagram
GPCR Downstream Signaling Pathway antibodies	GPCR Downstream Signaling Pathway Diagram
GPCR Ligand Binding Pathway antibodies	GPCR Ligand Binding Pathway Diagram

Diseases associated with CCL20 active protein

Disease Name	Pubmed Publications
Inflammation Antibodies	>311 publications with CCL20 and Inflammation
Necrosis Antibodies	>187 publications with CCL20 and Necrosis
Neoplasms Antibodies	>138 publications with CCL20 and Neoplasms
Skin Diseases Antibodies	>93 publications with CCL20 and Skin Diseases
Carcinoma Antibodies	>77 publications with CCL20 and Carcinoma
Lung Diseases Antibodies	>66 publications with CCL20 and Lung Diseases
Hypersensitivity Antibodies	>53 publications with CCL20 and Hypersensitivity
Liver Diseases Antibodies	>37 publications with CCL20 and Liver Diseases
Cardiovascular Diseases Antibodies	>30 publications with CCL20 and Cardiovascular Diseases
Neoplasms, Experimental Antibodies	>30 publications with CCL20 and Neoplasms, Experimental

Organs/Tissues associated with CCL20 active protein

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>453 publications with CCL20 and Blood
Intestine Antibodies	>102 publications with CCL20 and Intestine
Lung Antibodies	>84 publications with CCL20 and Lung
Vascular Antibodies	>75 publications with CCL20 and Vascular
Liver Antibodies	>66 publications with CCL20 and Liver
Mouth Antibodies	>30 publications with CCL20 and Mouth
Brain Antibodies	>29 publications with CCL20 and Brain
Kidney Antibodies	>27 publications with CCL20 and Kidney
Eye Antibodies	>23 publications with CCL20 and Eye
Uterus Antibodies	>18 publications with CCL20 and Uterus